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Dr. U. Satyanarayana - Biochemistry

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This textbook Biochemistry has become one of the most preferred text books (in India and many other countries) for the students as well as teachers in medical, biological and other allied sciences. The book has undergone three editions, several reprints, and revised reprints in a span of 13 years.There are many biochemistry textbooks in the market. Some of them are purely basic while others are applied, and there are very few books which cover both these aspects together. For this reason, the students learning biochemistry intheir undergraduate courses have to depend on multiple books to acquire a sound knowledge of the subject.This book, Biochemistry is unique with a simultaneous and equal emphasis on basic and applied aspects of biochemistry. This textbook offers an integration of medical and pure sciences, comprehensively written to meet the curriculum requirements of undergraduate courses in medical, dental, pharmacy, life-sciences and other categories (agriculture, veterinary, etc.).This book is designed to develop in students a sustained interest and enthusiasm to learn and develop the concepts in biochemistry in a logical and stepwise manner. It incorporates a variety of pedagogic aids, besides colour illustrations to help the students understand the subject quickly and to the maximum. The summary and biomedical/clinical concepts are intended for a rapid absorption and assimilation of the facts and concepts in biochemistry. The self-assessment exercises will stimulate the students to think rather than merely learn the subject. In addition, these exercises (essays, short notes, fill in the blanks, multiple choice questions) set at different difficulty levels, will cater to the needs of all the categories of learners.New to This Edition The book offers an integration of medical and pure sciences, and is comprehensively written, revised and updated to meet the curriculum requirements of Medical, Pharmacy, Dental, Veterinary, Biotechnology, Agricultural Sciences, Life Sciences, and others studying Biochemistry as one of the subjects. It is the first text book on Biochemistry in English with multi-colour illustrations by an author from Asia. The use of multicolours is for a clearer understanding of the complicated biochemical reactions. It is written in a lucid style with the subject being presented as an engaging story growing from elementary information to the most recent advances, and with theoretical discussions being supplemented with illustrations, flowcharts, and tables for easy understanding of Biochemistry. It has each chapter beginning with a four-line verse followed by the text, biomedical concepts, a summary, and self-assessment exercises. The lively illustrations and text with appropriate headings and sub-headings in bold type faces facilitate reading path clarity and quick recall. It provides the most recent and essential information on Molecular Biology and Biotechnology, Diabetes, Cancer, Free Radicals, Free radicals and Antioxidants, Prostaglandins, etc. It describes a wide variety of case studies and biochemical correlations and several newer biomedical aspects- Metabolic syndrome, Therapeutic diets, Atkins diet, Trans fatty acids, Epigenetics, Nutrigenomics, Recombinant ribozymes, Membrane transport disorders, Pleural fluid etc. It contains the basics (Bioorganic and Biophysical Chemistry, Tools of Biochemistry, Immunology, and Genetics) for beginners to learn easily Biochemistry, origins of biochemical words, confusables in Biochemistry, principles of Practical Biochemistry, and Clinical Biochemistry Laboratory.

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Table of Contents
List of tables
  1. Tables in Chapter 1
  2. Tables in Chapter 2
  3. Tables in Chapter 3
  4. Tables in Chapter 4
  5. Tables in Chapter 5
  6. Tables in Chapter 6
  7. Tables in Chapter 7
  8. Tables in Chapter 8
  9. Tables in Chapter 9
  10. Tables in Chapter 10
  11. Tables in Chapter 11
  12. Tables in Chapter 13
  13. Tables in Chapter 14
  14. Tables in Chapter 15
  15. Tables in Chapter 16
  16. Tables in Chapter 18
  17. Tables in Chapter 19
  18. Tables in Chapter 20
  19. Tables in Chapter 21
  20. Tables in Chapter 22
  21. Tables in Chapter 23
  22. Tables in Chapter 24
  23. Tables in Chapter 25
  24. Tables in Chapter 26
  25. Tables in Chapter 27
  26. Tables in Chapter 28
  27. Tables in Chapter 29
  28. Tables in Chapter 30
  29. Tables in Chapter 34
  30. Tables in Chapter 36
  31. Tables in Chapter 37
  32. Tables in Chapter 39
  33. Tables in Chapter 40
  34. Tables in Chapter 43
List of Figures
  1. Figures in Chapter 1
  2. Figures in Chapter 2
  3. Figures in Chapter 3
  4. Figures in Chapter 4
  5. Figures in Chapter 5
  6. Figures in Chapter 6
  7. Figures in Chapter 7
  8. Figures in Chapter 8
  9. Figures in Chapter 9
  10. Figures in Chapter 10
  11. Figures in Chapter 11
  12. Figures in Chapter 12
  13. Figures in Chapter 13
  14. Figures in Chapter 14
  15. Figures in Chapter 15
  16. Figures in Chapter 16
  17. Figures in Chapter 17
  18. Figures in Chapter 18
  19. Figures in Chapter 19
  20. Figures in Chapter 20
  21. Figures in Chapter 21
  22. Figures in Chapter 22
  23. Figures in Chapter 23
  24. Figures in Chapter 24
  25. Figures in Chapter 25
  26. Figures in Chapter 26
  27. Figures in Chapter 27
  28. Figures in Chapter 28
  29. Figures in Chapter 29
  30. Figures in Chapter 31
  31. Figures in Chapter 32
  32. Figures in Chapter 33
  33. Figures in Chapter 34
  34. Figures in Chapter 36
  35. Figures in Chapter 37
  36. Figures in Chapter 38
  37. Figures in Chapter 39
  38. Figures in Chapter 40
  39. Figures in Chapter 41
  40. Figures in Chapter 42
  41. Figures in Chapter 43
Landmarks
Biochemistry Fourth Edition U Satyanarayana MSc PhD FIC FACB - photo 1
Biochemistry

Fourth Edition

U. Satyanarayana, M.Sc., Ph.D., F.I.C., F.A.C.B.,

Professor of Biochemistry & Director (Research) Dr. Pinnamaneni Siddhartha Institute of Medical Sciences (Dr. NTR University of Health Sciences) Chinaoutpalli, Gannavaram (Mdl) Krishna (Dist), A.P., India

U. Chakrapani, M.B.B.S., M.S., D.N.B,

Copyright Biochemistry 4e Satyanarayana and Chakrapani ELSEVIER A division - photo 2

Copyright

Biochemistry, 4e

Satyanarayana and Chakrapani

ELSEVIER

A division of Reed Elsevier India Private Limited

Mosby, Saunders, Churchill Livingstone, Butterworth-Heinemann and Hanley & Belfus are the Health Science imprints of Elsevier.

2013 Dr. U. Satyanarayana

First Published: March 1999

Revised Reprint: August 2000

Second Revised Edition: June 2002

Revised Reprint: 2004, 2005

Third Revised Edition (multicolour): 2006

Revised Reprint: 2007, 2010

Fourth Revised Edition: 2013

All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the publishers.

ISBN: 978-81-312-3601-7

Medical knowledge is constantly changing. As new information becomes available, changes in treatment, procedures, equipment and the use of drugs become necessary. The author, editors, contributors and the publisher have, as far as it is possible, taken care to ensure that the information given in this text is accurate and up-to-date. However, readers are strongly advised to confirm that the information, especially with regard to drug dose/usage, complies with current legislation and standards of practice. Please consult full prescribing information before issuing prescriptions for any product mentioned in this publication.

This edition of Biochemistry, 4e by Dr. U. Satyanarayana and Dr. U. Chakrapani is co-published by an arrangement with Elsevier, a division of Reed Elsevier India Private Limited and Books and Allied (P) Ltd.

ELSEVIER

A division of Reed Elsevier India Private Limited.

Registered Office: 305, Rohit House, 3 Tolstoy Marg, New Delhi-110 001.

Corporate Office: 14th Floor, Building No. 10B, DLF Cyber City, Phase II, Gurgaon122 002, Haryana, India.

BOOKS AND ALLIED (P) Ltd.

Registered Office: 8/1 Chintamoni Das Lane, Kolkata 700009.

Corporate Office: No. 1-E(1) Shubham Plaza (1st Floor), 83/1, Beliaghata Main Road, Kolkata 700 010, West Bengal, India.

Cover Design

Depicts the universal energy currency of the living worldATP, predominantly synthesized by the mitochondria of the cell (the functional unit of life), in comparison with the international currencies$, , ,Preface to the Fourth Edition This book Biochemistry has undoubtedly - photo 3,.

Preface to the Fourth Edition This book Biochemistry has undoubtedly become one of the most preferred text - photo 4

This book Biochemistry has undoubtedly become one of the most preferred text books (in India and many other countries) by the students as well as teachers in medical, biological and other allied sciences. It is certainly a book of choice and a true companion to all learning biochemistry, hence appropriately regarded by many as Bible of Biochemistry. This book has undergone three editions, several reprints, and revised reprints in a span of 13 years.

The advances in biochemistry are evergrowing due to exponential growth of the subject. Further, the critical comments, frank opinions and constructive suggestions by teachers and students need to be seriously considered. All this necessitates frequent revision of the book.

In this fourth edition, a thorough revision and update of each chapter with latest advances has been done. The main emphasis of this edition is an improved orientation and treatment of human biochemistry in health and disease. A wide variety of case studies with relevant biochemical profiles (along with diagnosis and discussion) are newly added as an appendix. In addition, several newer aspects of biochemistry are covered in this edition, some of them are listed below.

Triacylgylcerol/fatty acid cycle

Metabolic syndrome

Glucose toxicity

Estimated average glucose

Peptide nucleic acids

Pseudogenes

Recombinant ribozymes

Epigenetic regulation of gene expression

Metagenomics

Therapeutic diets

Atkins diet

Dietary antioxidants

High fructose corn syrups

-fatty acid

Soluble and insoluble fiber

Trans fatty acids

Nutrigenomics

Detailed information on antivitamins

Dental caries

Amino acids as neurotransmitters

Disorders of membrane transport

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