Mills - Instrumental Data for Drug Analysis, Second Edition: Volume I

If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organiza-tion that provides licenses and registration for a variety of users.

For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. A Library of Congress record exists under LC control number: 93013539 Publishers Note The publisher has gone to great lengths to ensure the quality of this reprint but points out that some imperfections in the original copies may be apparent. Disclaimer The publisher has made every effort to trace copyright holders and welcomes correspondence from those they have been unable to contact. ISBN 13: 978-1-315-89457-7 (hbk) ISBN 13: 978-1-351-07367-7 (ebk) INSTRUMENTAL DATAFORDRUG ANALYSISCRC Series in Forensic and Police ScienceBARRY A.J. FISHER, EditorTECHNIQUES OF CRIME SCENE INVESTIGATION, Fourth Edition Barry A.J.

Fisher, Arne Svensson, and Otto Wendel SCIENTIFIC EXAMINATION OF QUESTIONED DOCUMENTS Ordway Hilton INSTRUMENTAL DATA FOR DRUG ANALYSIS, Second Edition Terry Mills III and J. Conrad Roberson CONTENTSVOLUME IVOLUME 2 DRUG DATA Doxepin-Naltrexone VOLUME 3 DRUG DATA Nandrolone Phenpropionate-Zoxazolamine VOLUME 4 APPENDIX A Standard KBr Infrared Spectra and Standard NMR Solvent Spectra APPENDIX B Supplemental Infrared Spectra APPENDIX C Supplemental NMR Spectra APPENDIX D Ultraviolet Absorption Maxima APPENDIX E Mass Spectral Index APPENDIX F Infrared Index APPENDIX G Gas Chromatographic Data APPENDIX H Molecular Formula Index INDEX TO SPECIFIC COMPOUNDS Almost everyone engaged in the analysis of drug-related compounds, whether in the forensic, clinical, or university laboratory, has an accumulation of analytical data and thus has acquired a data base of sorts for the analysis of these compounds. Unfortunately, many of these compilations contain a number of unauthenticated standards acquired over a long period of time using various techniques and, perhaps, several generations of instrumentation. Some of the information contained in Instrumental Data for Drug Analysis is available in the literature; however, there is no single source that contains timely, quality data of this type presented in a large, easily usable format. This four volume set is the result of our desire to provide each laboratory in our own system with an authentic, up-to-date data base for the instrumental analysis of drugs. These volumes are neither a text nor a cookbook.

They contain no analytical methods. They do provide the trained chemist with a single source of accurate instrumental data on twelve hundred drug-related compounds. We have included what we feel are the six currently most popular analytical techniques: ultraviolet (UV) spectrophotometry, infrared (IR) spectrophotometry, proton nuclear magnetic resonance (NMR) spectrometry, mass spectrometry (MS), gas chromatography (GC), and high pressure liquid chromatography (HPLC). As we felt that the quality of data presented was of paramount importance in a reference source, we generated all of our data in our laboratory under uniform, reproducible conditions using state-of-the-art technology and verified chemical standards. In the second edition, we have included several new appendixes. A collection of supplemental infrared and nuclear magnetic resonance spectra comprises two of these appendixes.

In these appendixes we have included many useful spectra not included in the main text. For those users who do not have the assistance of computer search systems, we have compiled an infrared peak table index. Another new appendix is the molecular formula index. All of the NMR data has been revised using a 300 MHz FTNMR system. The MS data has been replotted in a more readable format. We hope that this book will be as helpful to all analytical chemists as it is to us.

Terry Mills III J. Conrad Roberson The authors wish to express appreciation to the many individuals who contributed to this reference book by offering helpful suggestions, information, assistance, and reviews. We are grateful to Dr. Larry B. Howard, Director of the Division of Forensic Sciences, and Mr. E.P.

Peters, the late Director of the Georgia Bureau of Investigation, for making the facilities of the crime laboratory available for this work. The authors wish to thank the Hewlett-Packard Company for the use of the H-P 8450A UV-Vis spectrophotometer. We appreciate the assistance of Ron Haney and Patricia Price for helping with the mass spectral data. We also appreciate the members of the crime laboratory drug identification staff for their help. Our thanks are expressed to the following suppliers of drug standards: Abbott Laboratories; Adria Laboratories; Beechman Laboratories; Biocraft Laboratories; Brown Pharmaceutical Company; Burroughs Wellcome Company; Ciba Pharmaceutical Company; the Canadian Government; Danbury Pharmacal; Dermik Laboratories; Dista Products Company; Dorsey Laboratories; Drug Enforcement Administration (DEA); E.I. Dupont DeNemours & Company; Elder Pharmaceuticals; Geigy Pharmaceuticals; Graymor Chemical Company; Hoechst-Roussel Pharmaceuticals; Hoffmann-Laroche Inc.; Ives Laboratories; Jacobus Pharmaceutical Company; Janssen Pharmaceutica; Knoll Pharmaceutical Company; Lederle Laboratories; Lilly Research Laboratories; Marion Laboratories; McNeil Pharmaceutical; Mead Johnson Pharmaceutical Division; Merck Sharp & Dohme Research Laboratories; Merrell Dow Pharmaceuticals; Miles Pharmaceuticals; National Institute of Drug Abuse (NIDA); Norwick-Eaton Pharmaceuticals; ONeal, Jones & Feldman, Inc.; Ortho Pharmaceutical Corporation; Parke-Davis Pharmaceutical Company; Pennwalt Pharmaceutical Division; Pfizer Laboratories Division; William P.