Benjamin Sadock - Kaplan & Sadock’s Pocket Handbook of Psychiatric Drug Treatment

C ONSULTING E DITOR

S AMOON A HMAD , M.D.

Associate Professor and Attending Physician

Department of Psychiatry

NYU School of Medicine

New York, New York

Seventh Edition

B ENJAMIN J. S ADOCK , M.D.

Menas S. Gregory Professor of Psychiatry

Department of Psychiatry, New York University School of Medicine

Attending Psychiatrist, Tisch Hospital

Attending Psychiatrist, Bellevue Hospital Center

New York, New York

N ORMAN S USSMAN , M.D.

Professor of Psychiatry, Department of Psychiatry

New York University School of Medicine

New York, New York

V IRGINIA A. S ADOCK , M.D.

Professor of Psychiatry, Department of Psychiatry

New York University School of Medicine

Attending Psychiatrist, Tisch Hospital

Attending Psychiatrist, Bellevue Hospital Center

New York, New York

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7th edition

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Printed in China

Library of Congress Cataloging-in-Publication Data

Names: Sadock, Benjamin J., 1933- author. | Sussman, Norman, author. | Sadock, Virginia A., author.

Title: Kaplan & Sadocks pocket handbook of psychiatric drug treatment / Benjamin J. Sadock, Norman Sussman, Virginia A. Sadock.

Other titles: Kaplan and Sadocks pocket handbook of psychiatric drug treatment | Pocket handbook of psychiatric drug treatment

Description: Seventh edition. | Philadelphia : Wolters Kluwer, [2019] | Includes bibliographical references and index.

Identifiers: LCCN 2017055311 | ISBN 9781496389602

Subjects: | MESH: Mental Disordersdrug therapy | Psychotropic Drugstherapeutic use | Handbooks

Classification: LCC RC483 | NLM WM 34 | DDC 616.89/18dc23 LC record available at https://lccn.loc.gov/2017055311

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

Dedicated
to our children
James and Victoria
and to our grandchildren
Celia, Emily, Oliver, and Joel
B.J.S.
V.A.S.

Dedicated
to my wife Susan
and my children
Rebecca and Zachary
N.S.

This is the seventh edition of Kaplan & Sadocks Pocket Handbook of Psychiatric Drug Treatment, the first of which was published almost 25 years ago. During that time, a revolution in the treatment of mental illness occurred, sparked by the introduction of psychotropic drugs. This book has kept up with that revolution and contains information about every drug used in the treatment of mental illness. It has served the needs of many professionals who provide care for the mentally illpsychiatrists and nonpsychiatric physicians, psychiatric residents, medical students, clinical psychologists, psychiatric nurses, and others.

This book covers the entire spectrum of psychiatric drug therapy used in the clinical practice of psychiatry. As with each new edition, every section has been updated and revised and new sections added. Many drugs approved by the FDA as treatments for psychiatric disorders have been found to have benefits beyond those recognized at the time of their initial marketing, thus expanding the range of disorders that can be treated. Some have also been found to have unanticipated risks. These developments serve to emphasize the importance of having updated information about drug selection and use that reflects both research data and clinical experience. The goals of this book are to present this information clearly and concisely.

Following the format of previous editions, whenever possible, we classify drugs according to their pharmacological activity and mechanism of action rather than using such categories as antidepressants, antipsychotics, anxiolytics, and mood stabilizers which are overly broad. For example, many antidepressant drugs are used to treat anxiety disorders; some anxiolytics are used to treat depression and bipolar disorders; and drugs from all categories are used to treat other conditions such as eating disorders and impulse control disorders to name but two. This organization is used in textbooks of pharmacology and we believe psychopharmacology should follow that organization as much as possible, given the current state of our knowledge.

At the beginning of the book, the reader will find a chart (Table A) that lists each and every drug and the chapter in which it is found. In addition, the index lists each drug separately under its generic and brand name and the page number on which it can be found. Each section provides a wealth of data that includes (1) the drugs chemical name; (2) preparation and dosages; (3) pharmacologic actions including its pharmacokinetics and pharmacodynamics; (4) the indications for use and clinical applications; (5) use in children, elderly persons, and pregnant and nursing women; (6) side effects and adverse and allergic reactions; and (7) drugdrug interactions.