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Alan F Schatzberg - American Psychiatric Association Publishing Textbook of Psychopharmacology (Revised)

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Alan F Schatzberg American Psychiatric Association Publishing Textbook of Psychopharmacology (Revised)
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American Psychiatric Association Publishing Textbook of Psychopharmacology (Revised): summary, description and annotation

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The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs -- either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions -- from depression to chronic pain -- as well as for specific populations and circumstances -- from children and adolescents to psychiatric emergencies -- offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response.
The books beneficial features are many: - The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology.- History and discovery, structure--activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug--drug interactions are addressed for each agent. This consistent structure places the desired information at the clinicians fingertips and facilitates study for trainees.- Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine).- More than 180 tables and graphs present critically important data in an accessible way.
A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders.

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The American Psychiatric Association Publishing TEXTBOOK OF PSYCHOPHARMACOLOGY - photo 1

The American Psychiatric Association Publishing

TEXTBOOK OF

PSYCHOPHARMACOLOGY

FIFTH EDITION

The American Psychiatric Association Publishing

TEXTBOOK OF

PSYCHOPHARMACOLOGY

FIFTH EDITION

EDITED BY

Alan F. Schatzberg, M.D.

Charles B. Nemeroff, M.D., Ph.D.

Note The authors have worked to ensure that all information in this book is - photo 2

Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S. Food and Drug Administration and the general medical community. As medical research and practice continue to advance, however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family.

Books published by American Psychiatric Association Publishing represent the findings, conclusions, and views of the individual authors and do not necessarily represent the policies and opinions of American Psychiatric Association Publishing or the American Psychiatric Association.

If you wish to buy 50 or more copies of the same title, please go to www.appi.org/specialdiscounts for more information.

Copyright 2017 American Psychiatric Association Publishing
ALL RIGHTS RESERVED

Manufactured in the United States of America on acid-free paper
21 20 19 18 17 5 4 3 2 1
Fifth Edition

American Psychiatric Association Publishing
1000 Wilson Boulevard
Arlington, VA 22209-3901
www.appi.org

Library of Congress Cataloging-in-Publication Data

Names: Schatzberg, Alan F., editor. | Nemeroff, Charles B., editor. | American Psychiatric Association Publishing, publisher.

Title: The American Psychiatric Association Publishing textbook of psychopharmacology / edited by Alan F. Schatzberg, Charles B. Nemeroff.

Other titles: American Psychiatric Publishing textbook of psychopharmacology | Textbook of psychopharmacology

Description: Fifth edition. | Arlington, Virginia : American Psychiatric Association Publishing, [2017] | Preceded by The American Psychiatric Publishing textbook of psychopharmacology / edited by Alan F. Schatzberg, Charles B. Nemeroff. 4th ed. 2009. | Includes bibliographical references and index.

Identifiers: LCCN 2017004876 (print) | LCCN 2017005663 (ebook) | ISBN 9781585625239 (hardcover : alk. paper) | ISBN 9781615371228 (ebook)

Subjects: | MESH: Psychotropic Drugspharmacology | Psychotropic Drugstherapeutic use | Mental Disordersdrug therapy | Psychopharmacology

Classification: LCC RM315 (print) | LCC RM315 (ebook) | NLM QV 77.2 | DDC 615.7/8dc23

LC record available at https://lccn.loc.gov/2017004876

British Library Cataloguing in Publication Data

A CIP record is available from the British Library.

Dedicated to
our wives, children, and grandchildren,
who bring us much joy
and give us great support.

Contents

Jiang-Zhou Yu, MD., Ph.D.
Mark M. Rasenick, Ph.D.

Carolyn M. Drazinic, M.D., Ph.D.
Steven T. Szabo, M.D., Ph.D.
Todd D. Gould, M.D.
Husseini K. Manji, M.D., F.R.C.P.C.

Jessica Keverne, Ph.D.
Darina Czamara, Ph.D.
Joseph F. Cubells, M.D., Ph.D.
Elisabeth B. Binder, M.D., Ph.D.

Roxanne Keynejad, M.A., M.B.B.S., M.R.C.P.
Ania Korszun, Ph.D., M.D., F.R.C.Psych.
Carmine M. Pariante, Ph.D., M.D., F.R.C.Psych.

Firdaus S. Dhabhar, Ph.D.
Charles L. Raison, M.D.
Andrew H. Miller, M.D.

C. Lindsay DeVane, Pharm.D.

Ebrahim Haroon, M.D.
Helen Mayberg, M.D.

K. Ranga Rama Krishnan, M.D.

J. Craig Nelson, M.D.

Jerrold F. Rosenbaum, M.D.
Dawn F. Ionescu, M.D.

Linda L. Carpenter, M.D.
Alan F. Schatzberg, M.D.

Jonathon R. Howlett, M.D.
Murray B. Stein, M.D., M.P.H.
Charles B. Nemeroff, M.D., Ph.D.

Elias Aboujaoude, M.D.
Lorrin M. Koran, M.D.

Patrick H. Roseboom, Ph.D.
Ned H. Kalin, M.D.

Robert N. Golden, M.D.
Karon Dawkins, M.D.
Linda Nicholas, M.D.

Pierre Blier, M.D., Ph.D.

Alan F. Schatzberg, M.D.

David V. Hamilton, M.D., M.A.
Anita H. Clayton, M.D.

Michael E. Thase, M.D.

Sandhaya Norris, M.D.
Pierre Blier, M.D., Ph.D.

David S. Mathai, B.S.
Sanjay J. Mathew, M.D.

David V. Sheehan, M.D., M.B.A.

Donald S. Robinson, M.D.
Karl Rickels, M.D.

Henry A. Nasrallah, M.D.
Rajiv Tandon, M.D.

Stephen R. Marder, M.D.
Yvonne S. Yang, M.D., Ph.D.

Amy L. Silberschmidt, M.D.
Jacob S. Ballon, M.D.

S. Charles Schulz, M.D.

Peter F. Buckley, M.D.
Adriana E. Foster, M.D.
Matthew Byerly, M.D.

Michele Hill, M.R.C.Psych.
Donald C. Goff, M.D.

Rolando Gonzalez, M.D.
Martin T. Strassnig, M.D.

John W. Newcomer, M.D.
Elise Fallucco, M.D.
Martin T. Strassnig, M.D.

Leslie L. Citrome, M.D., M.P.H.

Peter F. Buckley, M.D.
Adriana E. Foster, M.D.
Oliver Freudenreich, M.D.
Scott Van Sant, M.D.

Philip D. Harvey, Ph.D.

Sultan Albrahim, M.D.
Joseph H. Henry, M.D.
Charles B. Nemeroff, M.D., Ph.D.

Joseph K. Stanilla, M.D.
George M. Simpson, M.D.

Masoud Kamali, M.D.
Venkatesh Basappa Krishnamurthy, M.D.
Raman Baweja, M.D.
Erika F.H. Saunders, M.D.
Alan J. Gelenberg, M.D.

Charles L. Bowden, M.D.

Po W. Wang, M.D.
Terence A. Ketter, M.D.
Robert M. Post, M.D.

Mark A. Frye, M.D.
Katherine Marshall Moore, M.D.
Alan F. Schatzberg, M.D.

David E. Kemp, M.D., M.S.
Marc L. van der Loos, M.D., Ph.D.
Keming Gao, M.D., Ph.D.
Joseph R. Calabrese, M.D.

Susan L. McElroy, M.D.
Paul E. Keck Jr., M.D.

Frank W. Brown, M.D.

Seiji Nishino, M.D., Ph.D.
Noriaki Sakai, D.V.M., Ph.D.
Kazuo Mishima, M.D., Ph.D.
Emmanuel Mignot, M.D., Ph.D.
William C. Dement, M.D., Ph.D.

Charles DeBattista, D.M.H., M.D.

William M. McDonald, M.D.
Thomas W. Meeks, M.D.
Linda L. Carpenter, M.D.

W. Vaughn McCall, M.D., M.S.
Charles F. Zorumski, M.D.

William V. Bobo, M.D., M.P.H.
Richard C. Shelton, M.D.

Paul E. Keck Jr., M.D.
Susan L. McElroy, M.D.

Daniella David, M.D.
Jonathan R.T. Davidson, M.D.

Tsung-Ung W. Woo, M.D., Ph.D.
Carla M. Canuso, M.D.
Joanne D. Wojcik, Ph.D., P.M.H.C.N.S.-B.C.
Douglas Noordsy, M.D.
Mary F. Brunette, M.D.
Alan I. Green, M.D.

Brian J. Sherman, Ph.D.
Karen J. Hartwell, M.D.
Aimee L. McRae-Clark, Pharm.D.
Kathleen T. Brady, M.D., Ph.D.

Marissa Miyazaki, M.D.
Daphne Simeon, M.D.
Eric Hollander, M.D.

W. Stewart Agras, M.D.

Andrew D. Krystal, M.D., M.S.

Kurt Kroenke, M.D.

Karen Dineen Wagner, M.D., Ph.D.
Steven R. Pliszka, M.D.

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