Jeffrey A. Lieberman MD (editor) - The American Psychiatric Association Publishing Textbook of Schizophrenia

SECOND EDITION

SECOND EDITION

EDITED BY

Jeffrey A. Lieberman, M.D.

T. Scott Stroup, M.D., M.P.H.

Diana O. Perkins, M.D., M.P.H.

Lisa B. Dixon, M.D., M.P.H.

Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and5 consistent with standards set by the U.S. Food and Drug Administration and the general medical community. As medical research and practice continue to advance, however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family.

Books published by American Psychiatric Association Publishing represent the findings, conclusions, and views of the individual authors and do not necessarily represent the policies and opinions of American Psychiatric Association Publishing or the American Psychiatric Association.

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Copyright 2020 American Psychiatric Association Publishing

ALL RIGHTS RESERVED

Second Edition

Manufactured in the United States of America on acid-free paper
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Library of Congress Cataloging-in-Publication Data

Names: Lieberman, Jeffrey A., 1948- editor. | Stroup, T. Scott, 1960- editor. | Perkins, Diana O., 1958- editor. | Dixon, Lisa B., editor. | American Psychiatric Association, issuing body.

Title: The American Psychiatric Association Publishing textbook of schizophrenia / edited by Jeffrey A. Lieberman, T. Scott Stroup, Diana O. Perkins, Lisa B. Dixon.

Other titles: American Psychiatric Publishing textbook of schizophrenia | Textbook of schizophrenia

Description: Second edition. | Washington, D.C. : American Psychiatric Association Publishing, [2020] | Preceded by The American Psychiatric Publishing textbook of schizophrenia / edited by Jeffrey A. Lieberman, T. Scott Stroup, Diana O. Perkins. 1st ed. c2006. | Includes bibliographical references and index.

Identifiers: LCCN 2019045877 (print) | LCCN 2019045878 (ebook) | ISBN 9781615371723 (hardcover ; alk. paper) | ISBN 9781615372911 (epub)

Subjects: MESH: Schizophrenia

Classification: LCC RC514 (print) | LCC RC514 (ebook) | NLM WM 203 | DDC 616.89/8dc23

LC record available at https://lccn.loc.gov/2019045877

LC ebook record available at https://lccn.loc.gov/2019045878

British Library Cataloguing in Publication Data

A CIP record is available from the British Library.

Bernardo Ng, M.D., DFAPA

Stephanie Martinez, M.D.

Steve Koh, M.D.

Mauricio Tohen, M.D., Dr.P.H., M.B.A.

James E. Gangwisch, Ph.D.

Diana O. Perkins, M.D., M.P.H.

Jeffrey A. Lieberman, M.D.

Ryan E. Lawrence, M.D.

Michael B. First, M.D.

Neil Krishan Aggarwal, M.D., M.B.A., M.A.

Roberto Lewis-Fernndez, M.D., M.T.S.

Matcheri S. Keshavan, M.D.

Paulo L. Lizano, M.D., Ph.D.

Seth W. Perry, Ph.D.

Konasale M. Prasad, M.D.

Julio Licinio, M.D., Ph.D.

Donald C. Goff, M.D.

L. Fredrik Jarskog, M.D.

T. Wilson Woo, M.D., Ph.D.

Treatment and
Rehabilitative Therapies

T. Scott Stroup, M.D., M.P.H.

Diana O. Perkins, M.D., M.P.H.

Daniel C. Javitt, M.D.

Alice Medalia, Ph.D.

Alice Saperstein, Ph.D.

Paul Grant, Ph.D.

Sarah Pratt, Ph.D.

Melanie Bennett, Ph.D.

Mary F. Brunette, M.D.

Michael T. Compton, M.D., M.P.H.

Marc W. Manseau, M.D., M.P.H.

Nev Jones, Ph.D.

Lisa B. Dixon, M.D., M.P.H.

Neil Krishan Aggarwal, M.D., M.B.A., M.A.

Assistant Professor of Clinical Psychiatry, Department of Psychiatry, Columbia University Medical Center; Research Psychiatrist, New York State Psychiatric Institute, New York, New York

Melanie Bennett, Ph.D.

Professor of Psychiatry, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland

Mary F. Brunette, M.D.

Associate Professor of Psychiatry, Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

Michael T. Compton, M.D., M.P.H.

Professor of Psychiatry, Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons; New York State Psychiatric Institute, New York, New York

Lisa B. Dixon, M.D., M.P.H.

Edna L. Edison Professor of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons; Director, Division of Behavioral Health Services and Policy Research and Center for Practice Innovations, New York State Psychiatric Institute, New York, New York

Michael B. First, M.D.

Professor of Clinical Psychiatry, Department of Psychiatry, Columbia University Irving Medical Center, New York, New York

James E. Gangwisch, Ph.D.

Assistant Professor of Clinical Psychiatric Social Work (in Psychiatry), Columbia University Irving Medical Center, New York, New York

Donald C. Goff, M.D.

Marvin Stern Professor of Psychiatry and Vice Chair for Research, Department of Psychiatry, NYU School of Medicine, New York; Director, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York

Paul Grant, Ph.D.

Research Assistant Professor of Psychology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

L. Fredrik Jarskog, M.D.

Professor and Director, North Carolina Psychiatric Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Daniel C. Javitt, M.D.

Professor of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Director, Division of Experimental Therapeutics, New York State Psychiatric Institute; Director, Schizophrenia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York

Nev Jones, Ph.D.

Assistant Professor, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida

Matcheri S. Keshavan, M.D.

Stanley Cobb Professor and Vice-Chair for Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts

Steve Koh, M.D.

Associate Professor and Director, Outpatient Psychiatric Services, Hillcrest; Director, Community Psychiatry Program; Director, TeleMentalHealth Program, University of California, San Diego, California