LitArk » Books » Home and family

Tracy I George - Atlas of Bone Marrow Pathology

Here you can read online Tracy I George - Atlas of Bone Marrow Pathology full text of the book (entire story) in english for free. Download pdf and epub, get meaning, cover and reviews about this ebook. year: 2018, publisher: Springer, genre: Home and family. Description of the work, (preface) as well as reviews are available. Best literature library LitArk.com created for fans of good reading and offers a wide selection of genres:

Romance novel Science fiction Adventure Detective Science History Home and family Prose Art Politics Computer Non-fiction Religion Business Children Humor

Choose a favorite category and find really read worthwhile books. Enjoy immersion in the world of imagination, feel the emotions of the characters or learn something new for yourself, make an fascinating discovery.

Book:
Atlas of Bone Marrow Pathology
Author:
Tracy I George
Publisher:
Springer
Genre:
Books / Home and family
Year:
2018
Rating:
4 / 5
Favourites:
Add to favourites
Your mark:
- 80
- 1
- 2
- 3
- 4
- 5

Description
Author's other books
Similar books

Atlas of Bone Marrow Pathology: summary, description and annotation

We offer to read an annotation, description, summary or preface (depends on what the author of the book "Atlas of Bone Marrow Pathology" wrote himself). If you haven't found the necessary information about the book — write in the comments, we will try to find it.

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis. After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body. This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders. The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms. The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification. This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.DOWNLOAD FROM FREE FILE STORAGE

Tracy I George: author's other books

Who wrote Atlas of Bone Marrow Pathology? Find out the surname, the name of the author of the book and a list of all author's works by series.

Atlas of Bone Marrow Pathology — read online for free the complete book (whole text) full work

Below is the text of the book, divided by pages. System saving the place of the last page read, allows you to conveniently read the book "Atlas of Bone Marrow Pathology" online for free, without having to search again every time where you left off. Put a bookmark, and you can go to the page where you finished reading at any time.

Light

Font size:

↓

↑

Reset

Interval:

↓

↑

Bookmark:

Make

Springer Science+Business Media, LLC 2018

Tracy I. George and Daniel A. Arber (eds.) Atlas of Bone Marrow Pathology Atlas of Anatomic Pathology

1. Normal Bone Marrow

Heesun J. Rogers 1

(1)

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA

Heesun J. Rogers

Email:

Keywords

Cellularity Erythroid cell Granulocyte Hematopoietic cell Megakaryocyte Normal bone marrow Stromal cell

The bone marrow examination is an important diagnostic procedure used for a wide variety of clinical conditions such as the diagnosis of myeloid or lymphoid neoplasms, various reactive conditions or metastatic, non-hematopoietic malignancies. Bone marrow examination is also used for confirmation or monitoring of a remission state, residual or recurrent disease state, or regeneration of bone marrow after various therapies. Bone marrow aspiration and biopsy of adequate quality are considered to represent overall bone marrow function.

A basic understanding of bone marrow structures and the correct identification of cells comprising normal bone marrow are very important in the interpretation of bone marrow pathology. The bone marrow is a well-organized structure confined in cortical bone and traversed by medullary or trabecular bone. The bone marrow has three components: hematopoietic cells, stroma/microenvironment, and medullary bone. Hematopoietic cells are embedded in a connective tissue stroma in intertrabecular spaces of medullary bone. The bone marrow is almost entirely occupied by hematopoietic cells, with the highest cellularity at birth or early infancy. The hematopoietic cells gradually decrease in the bone marrow with aging, and the bone marrow is replaced by adipose cells (fat cells). Hematopoietic cells derived from multipotent stem cells can be further differentiated into several lineage cells: erythrocytes, granulocytes, monocytes, megakaryocytes , and lymphocytes.

Tables list the characteristic cytologic features of erythroid cells, granulocytic cells, and megakaryocytic cells. These tables illustrate the various stages of maturation from the earliest recognizable immature cells to mature cells in the bone marrow. Erythroid precursor cells (normoblast or erythroblast) develop adjacent to macrophages and are subdivided into pronormoblasts, basophilic normoblasts, polychromatophilic normoblasts, and orthochromic normoblasts. Immature granulocytic cells develop adjacent to trabecular surfaces or arterioles and are further subdivided into blasts, promyelocytes, myelocytes, metamyelocytes, band neutrophils, and segmented neutrophils. Megakaryocytes, the largest hematopoietic cells in bone marrow, can be easily identified adjacent to sinusoids, but megakaryoblasts or immature megakaryocytes are often difficult to recognize in the bone marrow and can be readily identified in conjunction with immunohistochemistry or immunophenotype.

Table 1.1

Maturation of erythroid cells in bone marrow

Cell type	Characteristic morphology	Description
Pronormoblast (proerythroblast)		The most immature and largest cells in erythroid lineage (1224 m), relatively high nuclear to cytoplasmic (N/C) ratio (78:1), round to slightly oval nucleus, finely reticulated chromatin, prominent nucleoli ( 1), and agranular basophilic cytoplasm
Basophilic normoblast		Smaller cells (1017 m) than pronormoblast, round nucleus, high N/C ratio (6:1), open to slightly condensed chromatin, distinct parachromatin, rarely visible or absent nucleoli in later stage, and deep basophilic cytoplasm
Polychromatophilic normoblast		Smaller cells (1015 m) and lower N/C ratio (4:1) than basophilic normoblasts, round nucleus with condensed chromatin, often cartwheel appearance, visible perinuclear halo, no nucleoli, and blue-gray to pink-gray cytoplasm
Orthochromic normoblast		More mature and smaller cells (812 m) than polychromatophilic normoblast, abundant cytoplasm (N/C ratio 1:2) with pink-orange and minimally basophilic color similar to erythrocytes, round nucleus, and densely condensed or pyknotic chromatin
Erythrocyte		The most mature cells (78.5 m), pink-orange to salmon color, and no nucleus

Table 1.2

Maturation of granulocytic cells in the bone marrow

Cell type	Characteristic morphology	Description
Myeloblast		The most immature granulocytic cells (1520 m), with high N/C ratio (47:1), round to oval nucleus, fine to reticular chromatin with distinct nucleoli (15), and moderately basophilic cytoplasm with absent or minimal azurophilic granules
Promyelocyte		Slightly larger cells (1424 m) than myeloblasts, with high N/C ratio (35:1), eccentric round to oval nucleus, slightly coarse or finely reticular chromatin, distinct nucleoli (13), basophilic cytoplasm with paranuclear hof and prominent azurophilic (primary) granules, which may overlie the nucleus
Myelocyte		Slightly smaller cells (1018 m) than blasts, with more abundant cytoplasm (N/C ratio 12:1), eccentric round to oval nucleus, more condensed chromatin, no nucleoli, bluish to pink cytoplasm with paranuclear hof, abundant lilac (secondary) granules, and scattered few azurophilic (primary) granules
Metamyelocyte		Size similar to or slightly smaller (1018 m) than myelocytes, with abundant cytoplasm (N/C ratio 11.5:1), indented or kidney-shaped nucleus (indentation less than half the width of the nuclear margin), condensed chromatin, no nucleoli, pinkish cytoplasm with many secondary granules and rare primary granules
Band neutrophil

Light

Font size:

↓

↑

Reset

Interval:

↓

↑

Bookmark:

Make

Similar books «Atlas of Bone Marrow Pathology»

Look at similar books to Atlas of Bone Marrow Pathology. We have selected literature similar in name and meaning in the hope of providing readers with more options to find new, interesting, not yet read works.

Yan Lianke

Marrow

Alexis Smith

Marrow Island

F Wilson

Deep as the Marrow

Shauna C. Anderson Young

Andersons Atlas of Hematology

Ted Geltner

Blood, Bone, and Marrow: A Biography of Harry Crews

Meral Beksaç

Bone Marrow and Stem Cell Transplantation

Ilaslan Hakan

Pediatric and Adult MRI Atlas of Bone Marrow Normal Appearances, Variants and Diffuse Disease States

Jeffrey Y. C. Wong

Total Marrow Irradiation: A Comprehensive Review

Robert Reed

Marrow

Jwing-Ming Yang

Qigong, The Secret of Youth: Da Mo’s Muscle/Tendon Changing and Marrow/Brain Washing Classics

Islam

Manual of bone marrow examination

Mantak Chia

Bone Marrow Nei Kung: Taoist Techniques for Rejuvenating the Blood and Bone

Reviews about «Atlas of Bone Marrow Pathology»

Discussion, reviews of the book Atlas of Bone Marrow Pathology and just readers' own opinions. Leave your comments, write what you think about the work, its meaning or the main characters. Specify what exactly you liked and what you didn't like, and why you think so.