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Phoebe Lin - Uveitis

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Phoebe Lin Uveitis

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This book discusses the main clinical aspects of common uveitic infectious and non-infectious entities, the diagnostic work-up, and the treatment/management options based on the literature, where available, and clinical experience. Providing a quick reference guide to uveitis and retina fellows as well as general ophthalmologists, this comprehensive book includes chapters on diagnostic biopsy and pediatric uveitis, as well as reference tables and figures. As part of the series Current Practices in Ophthalmology this book is intended for residents, fellows-in-training, generalist ophthalmologists and specialists alike.

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Current Practices in Ophthalmology Series Editor Parul Ichhpujani Department - photo 1
Current Practices in Ophthalmology
Series Editor
Parul Ichhpujani
Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India

This series of highly organized and uniform handbooks aims to cover the latest clinically relevant developments in ophthalmology. In the wake of rapidly evolving innovations in the field of basic research, pharmacology, surgical techniques and imaging devices for the management of ophthalmic disorders, it is extremely important to invest in books that help you stay updated. These handbooks are designed to bridge the gap between journals and standard texts providing reviews on advances that are now part of mainstream clinical practice. Meant for residents, fellows-in-training, generalist ophthalmologists and specialists alike, each volume under this series covers current perspectives on relevant topics and meets the CME requirements as a go-to reference guide. Supervised and reviewed by a subject expert, chapters in each volume provide leading-edge information most relevant and useful for clinical ophthalmologists. This series is also useful for residents and fellows training in various subspecialties of ophthalmology, who can read these books while at work or during emergency duties. Additionally, these handbooks can aid in preparing for clinical case discussions at various forums and examinations.

More information about this series at http://www.springer.com/series/15743

Editor
Phoebe Lin
Uveitis
Editor Phoebe Lin Casey Eye Institute Oregon Health Science University - photo 2
Editor
Phoebe Lin
Casey Eye Institute Oregon Health & Science University, Portland, OR, USA
ISSN 2523-3807 e-ISSN 2523-3815
Current Practices in Ophthalmology
ISBN 978-981-15-0330-6 e-ISBN 978-981-15-0331-3
https://doi.org/10.1007/978-981-15-0331-3
Springer Nature Singapore Pte Ltd. 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.

The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Contents
Kristin Biggee
K. Matthew McKay and Nicholas J. Butler
Akshay S. Thomas
Mohsin H. Ali , Wenlan Zhang and Dilraj S. Grewal
Ashlin Joye and John Gonzales
Phoebe Lin
Christopher D. Conrady , Lynn Hassman and Akbar Shakoor
Jaya B. Kumar and Sumit Sharma
Eric Crowell and Ashvini Reddy
About the Editor
Phoebe Lin MD, PhD

completed her ophthalmology residency at the University of California San Francisco and a two-year fellowship in vitreoretinal surgery and disease at Duke University, where she was awarded a Heed Foundation fellowship and the Ron G. Michels fellowship. She then completed a one-year fellowship in uveitis and ocular inflammation at the Casey Eye Institute. Dr. Lin is currently an Associate Professor of Ophthalmology in the divisions of Retinal/Vitreous Diseases and Uveitis/Ocular Immunology at the Casey Eye Institute, where she participates in the education of surgical retina fellows, uveitis fellows, and ophthalmology residents, and also pursues independent research using animal models to identify novel therapeutic targets for uveitis. She has published over 70 peer-reviewed papers, book chapters, and other articles; is on the executive committee of the American Uveitis Society and the planning committee of the American Academy of Ophthalmology Uveitis subspecialty day meeting; and is an editor for the American Society of Retina Specialists publication,Retina Times.

Springer Nature Singapore Pte Ltd. 2020
P. Lin (ed.) Uveitis Current Practices in Ophthalmology https://doi.org/10.1007/978-981-15-0331-3_1
1. Noninfectious Anterior Uveitis
Kristin Biggee
(1)
Kaiser Northwest Permanente, Portland, OR, USA
Kristin Biggee
Email:
Keywords
Noninfectious anterior uveitis HLA B27 uveitis Differential diagnosis of anterior uveitis Treatment of anterior uveitis
Introduction
Anterior uveitis encompasses a heterogenous group of disorders that can be divided into infectious versus noninfectious causes. It is defined anatomically by the Standardization of Uveitis Nomenclature (SUN) working group, as intraocular inflammation in which the predominant site of inflammation occurs in the anterior chamber. Anterior uveitis encompasses the previously used terms, including iritis, iridocyclitis, and anterior cyclitis. It can be further categorized based on degree of onset, duration, and course (Table ]. Further descriptors include laterality, inflammation of specific anterior segment structures, and/or the presence of granulomatous clinical entities. Categorization using the above terms can help clinicians determine different underlying diagnoses and treatment strategies.
Table 1.1

SUN working group descriptors of uveitis []

Category

Descriptor

Definition

Onset

Sudden

Insidious

Duration

Limited

Less than 3-month duration

Persistent

More than 3-month duration

Course

Acute

Episode includes sudden onset and limited duration

Recurrent

Repeated episodes that are separated by 3 months or more of inactivity off treatment

Chronic

Persistent uveitis with repeat episodes occurring within 3 months after discontinuing treatment

Epidemiology and Demographics

Anterior uveitis has been reported as the most frequent anatomical subtype of uveitis among various groups and population studies [].

Females tend to have higher incidence and prevalence compared to males, but this can vary depending on underlying disease entity [].

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