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A. Douglas Kinghorn Heinz Falk Simon Gibbons - Phytocannabinoids

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A. Douglas Kinghorn Heinz Falk Simon Gibbons Phytocannabinoids

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Secondary Metabolites from Higher Fungi; 1 Introduction; 2 Pigments of Higher Fungi; 2.1 Introduction; 2.2 Pigments from the Shikimate-Chorismate Pathway; 2.2.1 Pigments Derived from Arylpyruvic Acids; Terphenylquinones; Pulvinic Acids and Related Butenolides; 2.2.2 Pigments Derived from Cinnamic Acids; 2.2.3 Meroterpenoids Derived from Hydroquinone; Prenylated Benzene Derivatives; Meromonoterpenoids; Merosesquiterpenoids; Meroditerpenoids; 2.3 Pigments from the Acetate-Malonate Pathway; 2.3.1 Pentaketides; 2.3.2 Hexaketides; 2.3.3 Octaketides; Azaphilone Pigments.;The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms. .

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Springer International Publishing Switzerland 2017
A. Douglas Kinghorn , Heinz Falk , Simon Gibbons and Jun'ichi Kobayashi (eds.) Phytocannabinoids Progress in the Chemistry of Organic Natural Products 10.1007/978-3-319-45541-9_1
Phytochemistry of Cannabis sativa L.
Mahmoud A. ElSohly 1, 2
(1)
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
(2)
ElSohly Laboratories, Inc., 5 Industrial Park Drive, Oxford, MS 38655, USA
Mahmoud A. ElSohly (Corresponding author)
Email:
Mohamed M. Radwan (Corresponding author)
Email:
Waseem Gul
Email:
Suman Chandra
Email:
Ahmed Galal
Email:
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6.2
Keywords
Botany of Cannabis sativa Definitions of cannabis and cannabinoids Outdoor cultivation Indoor cultivation Propagation Micropropagation Chemotaxonomy Biosynthesis Cannabinoids from C. sativa Non-cannabinoids from C. sativa Analytical methods HPLC UPLC GC/FID GC/MS HPTLC
Mahmoud A ElSohly is a Research Professor at the National Center for Natural - photo 1
Mahmoud A. ElSohly
is a Research Professor at the National Center for Natural Products Research, and Professor of Pharmaceutics in the Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS, USA (1984present). He is the Project Director, National Institute on Drug Abuse Marijuana Project at the University of Mississippi (1981present). He is President and Director of ElSohly Laboratories Incorporated, Oxford, MS, USA, a small company providing precision analytical testing and manufacturing services for the drug testing industry since 1985 . He obtained a Ph.D. degree in Pharmacy (Pharmacognosy) from the University of Pittsburgh, Pittsburgh, PA, USA in 1975. Dr. ElSohly holds more than 30 patents dealing with the processing, testing, and detection of drugs of abuse along with other patents dealing with biologically active natural products. He has authored over 300 peer-reviewed scholarly articles published in top-tier international journals. He is a member of 14 scholarly scientific societies and was recognized by The Scientist (April 17, 1995) and Science Watch (January, 1995) as the second most cited author in forensic sciences in the world for the period 19811993.
Mohamed M Radwan has been a Research Scientist at the National Center for - photo 2
Mohamed M. Radwan
has been a Research Scientist at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, USA since 2011. He obtained his Bachelors, Masters and Ph.D. degrees in Pharmaceutical Sciences from the University of Alexandria, Egypt. He worked as a postdoctoral Research Associate at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA from 20052011. Dr. Radwan has co-authored more than 60 peer-reviewed scholarly articles. His research is focused on the isolation and structural elucidation of bioactive metabolites from plant, marine and fungal sources with special emphasis on the phytochemistry and analysis of Cannabis sativa . Dr. Radwan has experience in the production of C. sativa extracts and purified cannabinoid constituents under GMP guidelines.
Waseem Gul has been Associate Director of Research at ElSohly Laboratories - photo 3
Waseem Gul
has been Associate Director of Research at ElSohly Laboratories Inc., Oxford, MS, USA since 2003. He has also been an Adjunct Research Scientist at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, USA since 2004. He has a Bachelors degree in Chemistry and a Masters degree in Organic Chemistry from University of Peshawar, Pakistan, and a Ph.D. degree in Chemistry from Gomal University, Pakistan. He worked as a postdoctoral Research Associate at the University of Calgary, Alberta, Canada (20012002) and at the Department of Pharmacognosy, School of Pharmacy, University of Mississippi (20022003). Dr. Gul has co-authored more than 50 peer-reviewed scholarly articles and several book chapters and has seven issued patents. His research is focused on the synthesis of prodrugs and drugs, formulation, stability and pharmacokinetics of drugs and prodrugs, and analytical chemistry, with special emphasis on the analysis of drugs of abuse. Dr. Gul is also working on the GMP synthesis of drugs under FDA guidelines at ElSohly Laboratories.
Suman Chandra received a MPhil degree in Environmental Plant Physiology and a - photo 4
Suman Chandra
received a M.Phil. degree in Environmental Plant Physiology and a Ph.D. degree in Plant Physiology from The High Altitude Plant Physiology Research Center, HNB Garhwal University, India. He worked at The High Altitude Plant Physiology Research Center and the GB Pant Institute of Himalayan Environment and Development, India from 1992 to 2000. Dr. Chandra joined the University of Mississippi, MS, USA in 2001 and is currently working as a Senior Research Scientist at The National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences (RIPS), School of Pharmacy. His research interests include the conservation, cultivation and improvement of medicinal plants, and effects of climatic changes on physiology and secondary metabolites of medicinally important plants. Dr. Chandra has more than 50 publications, 100 meeting presentations, and an edited book in his credit.
Ahmed Galal has been a Research Scientist at the National Center for Natural - photo 5
Ahmed Galal
has been a Research Scientist at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, USA since 2010. Prior to this, he performed postdoctoral work on Cannabis sativa with Dr. Mahmoud Elsohly for three years (20072010). He obtained a Bachelors degree and then a Masters degree in Pharmacognosy from the School of Pharmacy, Cairo University, Cairo, Egypt. He obtained his Ph.D. in 1987 from the Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA, USA, specializing in the chemistry of natural products. Before joining the University of Mississippi, he was a professor at the Department of Pharmacognosy, School of Pharmacy, King Saud University, Saudi Arabia. Dr. Galal has filed two patents on artemisinin dimers, and co-authored two book chapters, six reviews, and 60 peer-reviewed scholarly articles. Currently, he is a member of the Editorial Board of the journal Recent Patents on Anti-Infective Drug Discovery. At present, he is involved in FDA training sessions for inspectors on the identification and adulteration of botanical ingredients of dietary supplements. Dr. Galals recent research focus is directed towards the isolation and structural elucidation of natural products for subsequent bioactivity evaluation. In addition, he has contributed to synthetic modification of natural product lead compounds.
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