F. E. R. Simons - Histamine and H1-receptor antagonists in allergic disease
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Histamine and H1-receptor antagonists in allergic disease
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This work provides comprehensive, up-to-date information on histamine receptors and H1-receptor antagonists, reviewing fundamental science and presenting advances in therapy. It discusses novel H1-receptor antagonists, including loratadine, cetrizine and acrivastine, and examines the role of topical H1-antagonists such as levocabastine and azelastine. The clinical scientific basis of antagonistic use is explored.
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Histamine and H1-Receptor Antagonists in Allergic Disease
Page ab
CLINICAL ALLERGY AND IMMUNOLOGY
Series Editor
MICHAEL A. KALINER, M.D.
Medical Director Institute for Asthma and Allergy Washington, D.C.
1. Sinusitis: Pathophysiology and Treatment, edited by Howard M. Druce
2. Eosinophils in Allergy and Inflammation, edited by Gerald J. Gleich and A. Barry Kay
3. Molecular and Cellular Biology of the Allergic Response, edited by Arnold I. Levinson and Yvonne Paterson
4. Neuropeptides in Respiratory Medicine, edited by Michael A. Kaliner, Peter J. Barnes, Gert H. H. Kunkel, and James N. Baraniuk
5. Provocation Testing in Clinical Practice, edited by Sheldon L. Spector
6. Mast Cell Proteases in Immunology and Biology, edited by George H. Caughey
7. Histamine and H1-Receptor Antagonists in Allergic Disease, edited by F. Estelle R. Simons
ADDITIONAL VOLUMES IN PREPARATION
Immunopharmacology of Allergic Diseases, edited by Robert G. Townley and Devendra K. Agrawal
Page i
Histamine and H1-Receptor Antagonists in Allergic Disease
edited by F. Estelle R. Simons University of Manitoba Winnipeg, Manitoba, Canada
Marcel Dekker, Inc. New YorkBaselHong Kong
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Library of Congress Cataloging-in-Publication Data
Histamine and H1-receptor antagonists in allergic disease / edited by F. Estelle R. Simons. p. cm. (Clinical allergy and immunology; 7) Includes index. ISBN 0-8247-9509-1 (alk. paper) 1. Antihistamines. 2. Allergy Chemotherapy. 3. Histamine Receptors. 4. Histamine. I. Simons, F. E. R. II. Series. [DNLM: 1. Hypersensitivity immunology. 2. Histamine H1 Antagonists immunology. 3. Receptors, Histamine immunology. 4. Histamine immunology. W1 CL652 v.7 1996 / QW 900 S588 1996] RM666.A5H55 1996 616.97'061dc20 DNLM/DLC for Library of Congress 96-4746 CIP
The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the address below.
This book is printed on acid-free paper.
Copyright 1996 by Marcel Dekker, Inc. All Rights Reserved.
Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016
Dedicated with deepest gratitude to my father, Francis Raymond Edward Davies (19101995).
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SERIES INTRODUCTION
The decision to initiate a series of books on clinical allergy and immunology was based upon the need to create a library of texts useful for clinicians and scientists in these rapidly enlarging fields. There already are excellent textbooks providing overviews of the fields of allergy and immunology, and the scientific journals attempt to provide concise reviews of selected topics of interest. However, there is no library of books that takes relevant topics and expands them into texts for the express purpose of making them of interest to practicing physicians and researchers. Thus, this new series.
Clinical Allergy and Immunology will develop into the premier series of texts for our field. The initial books have addressed sinusitis, eosinophils, molecular biology, neuropeptides, provocation testing, and now histamine and its receptors. The benefactors of this series should be patients with allergic disorders because their physicians will now have a source of concise but authoritative summaries of a field. The other major benefactors will be clinicians. Despite the fact that allergy is the single most prevalent chronic disease suffered by humans, only a small number of medical schools incorporate allergy into their curricula, and many medical students are notably deficient in their knowledge of these diseases. As allergy is largely an outpatient specialty, few house officers see allergic patients other than those experiencing acute asthma or anaphylaxis. To clinicians,
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this series offers the chance to develop an extensive knowledge about selected topics, each chosen for its clinical relevance.
Histamine holds a special place in allergy. It was the first mediator to be associated with allergic reactions, and was the first whose inhibition proved useful in the management of disease. Much success has accompanied the use of antihistamines, and scientists have continued to create new and safer antihistamines for clinical use. This book provides the most current and useful information on histamine and its antagonists. As with all others in the series, it satisfies needs in both clinical and research areas and should prove very helpful for providing new insights and new directions. We welcome this work to the series.
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