Eri Oshima - Traditional Chinese Medicine

Traditional Chinese Medicine

Scientific Basis for Its Use

RSC Drug Discovery Series

Editor-in-Chief

Professor David Thurston, Kings College, London, UK

Series Editors:

Dr David Fox, Vulpine Science ad Learning, UK

Professor Salvatore Guccione, University of Catania, Italy

Professor Ana Martinez, Instituto de Quimica Medica-CSIC, Spain

Professor David Rotella, Northeastern University, USA

Advisor to the Board:

Professor Robin Ganellin, University College London, UK

Titles in the Series:

1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups

2: Emerging Drugs and Targets for Alzheimers Disease; Volume 1

3: Emerging Drugs and Targets for Alzheimers Disease; Volume 2

4: Accounts in Drug Discovery

5: New Frontiers in Chemical Biology

6: Animal Models for Neurodegenerative Disease

7: Neurodegeneration

8: G Protein-Coupled Receptors

9: Pharmaceutical Process Development

10: Extracellular and Intracellular Signaling

11: New Synthetic Technologies in Medicinal Chemistry

12: New Horizons in Predictive Toxicology

13: Drug Design Strategies: Quantitative Approaches

14: Neglected Diseases and Drug Discovery

15: Biomedical Imaging

16: Pharmaceutical Salts and Cocrystals

17: Polyamine Drug Discovery

18: Proteinases as Drug Targets

19: Kinase Drug Discovery

20: Drug Design Strategies: Computational Techniques and Applications

21: Designing Multi-Target Drugs

22: Nanostructured Biomaterials for Overcoming Biological Barriers

23: Physico-Chemical and Computational Approaches to Drug Discovery

24: Biomarkers for Traumatic Brain Injury

25: Drug Discovery from Natural Products

26: Anti-Inflammatory Drug Discovery

27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules

28: Drug Discovery for Psychiatric Disorders

29: Organic Chemistry of Drug Degradation

30: Computational Approaches to Nuclear Receptors

31: Traditional Chinese Medicine

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK

Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247,

Email: booksales@rsc.org

Visit our website at www.rsc.org/books

Traditional Chinese Medicine

Scientific Basis for Its Use

Edited by

James David Adams Jr

School of Pharmacy, University of Southern California, Los Angeles, CA, USA
Email: jadams@usc.edu

Eric J. Lien

School of Pharmacy, University of Southern California, Los Angeles, CA, USA
Email: elien@usc.edu

RSC Drug Discovery Series No. 31

ISBN: 978-1-84973-661-9

ISSN: 2041-3203

A catalogue record for this book is available from the British Library

The Royal Society of Chemistry 2013

All rights reserved

Apart from fair dealing for the purposes of research for non-commercial purposes or for private study, criticism or review, as permitted under the Copyright, Designs and Patents Act 1988 and the Copyright and Related Rights Regulations 2003, this publication may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry or the copyright owner, or in the case of reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page.

The RSC is not responsible for individual opinions expressed in this work.

Published by The Royal Society of Chemistry,

Thomas Graham House, Science Park, Milton Road,

Cambridge CB4 0WF, UK

Registered Charity Number 207890

For further information see our web site at www.rsc.org

Preface

I believe in the goodness of the American and Chinese people who remain good friends.

Dr Hua Chuen Mei
from Dr Hua Chuen Mei May 30, 1925 available at
www.abeduspress.com.

Linda Mei Adams, my wife, is the grand-daughter of Dr Hua Chuen Mei, who was an American lawyer in Shanghai who defended several Chinese students accused of rioting in the International Settlement at the Louza Police Station on 30 May 1925. He won the case in June 1925, which led to the May 30 Movement in China. My wife and her mother, Eva Lum Mei, taught me to speak Cantonese. My wifes grand-mother, Polly Lum, used Traditional Chinese Medicine even though her son, son-in-law and grand-son were all Western-trained MDs. I am grateful to the Mei and Lum families for helping me learn the utility of Traditional Chinese Medicine, even when American Medicine may not recognize the utility. I was able to learn the philosophy for using Traditional Chinese Medicine, which differs greatly from the medicine I learned as a Graduate Student of Pharmacology at the University of California San Francisco. This philosophy depends on living in balance in order to be healthy. I was also taught the importance of spirituality in health, since health requires a healthy body, mind and spirit. My poem below is be kind to yourself, be kind to others, allow God to love you. My Chinese name, below, is Ha Cheen Sing, Summer Thousand Honest, and was given to me by my mother-in-law.

I am grateful to Professor Eric Lien for encouraging me to think about the Science involved in Traditional Chinese Medicine. This has been a great challenge for me and resulted in this book. I am grateful to all the authors of the chapters who have applied their great expertise in this book.

James David Adams Jr, PhD
Associate Professor of Pharmacology and Pharmaceutical Sciences
School of Pharmacy, University of Southern California
Los Angeles, CA, USA

Knowledge and Health

Knowledge and learning have no limits.

Teaching and learning reinforce each other.

Education should not discriminate against anyone.

Doing good deeds brings the most happiness.

New knowledge can promote good health, enhance productivity and contribute to longevity.

Sustain vitality and youthfulness as long as possible.

Good memories will last forever.

Eric J. Lien, PhD
Professor Emeritus
School of Pharmacy, University of Southern California
Los Angeles, CA, USA

Contents

James D. Adams Jr and Eric J. Lien

Eric J. Lien, Linda L. Lien and James D. Adams

Minchen Wang (Vince)

Marcia R. Babcock

Calvin Yu-Chian Chen

Kuo-Hsiung Lee, Susan L. Morris-Natschke, Joshua Brattlie, Jingxi Xie and Eileen Belding

Yang Li, Anketse Kassa and Bangyan L. Stiles

William C. S. Cho

Constance L. L. Saw, Chee L. Saw and Lita S. T. Chew

James David Adams Jr

Jiangang Shen and Xingmiao Chen

Eri Oshima

Zhijun Wang, Patrick Chan and Jeffrey Wang