Gregory P. Kalemkerian - Handbook of Lung Cancer and Other Thoracic Malignancies

Handbook of Lung Cancer and
Other Thoracic Malignancies

Handbook of Lung Cancer and
Other Thoracic Malignancies

Editors

Gregory P. Kalemkerian, MD

Professor, Co-Director of Thoracic Oncology

Division of Hematology/Oncology

Department of Internal Medicine

University of Michigan

Ann Arbor, Michigan

Jessica S. Donington, MD

Associate Professor

Cardiothoracic Surgery

NYU Medical Center

New York, New York

Elizabeth M. Gore, MD

Professor, Department of Radiation Oncology

Medical College of Wisconsin

Milwaukee, Wisconsin

Suresh S. Ramalingam, MD

Professor of Hematology and Medical Oncology

Director, Division of Medical Oncology

Assistant Dean for Cancer Research

Emory University School of Medicine;

Deputy Director, Winship Cancer Institute

Atlanta, Georgia

Visit our website at www.demosmedical.com

ISBN: 9781620700969

e-book ISBN: 9781617052729

Acquisitions Editor: David DAddona

Compositor: diacriTech

Copyright 2017 Springer Publishing Company.

Demos Medical Publishing is an imprint of Springer Publishing Company, LLC.

All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher.

Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market.

Library of Congress Cataloging-in-Publication Data

Names: Kalemkerian, Gregory, editor. | Donington, Jessica, editor. | Gore, Elizabeth (Professor), editor. | Ramalingam, Suresh, editor.

Title: Handbook of lung cancer and other thoracic malignancies / editors, Gregory P. Kalemkerian, MD, Professor, Co-Director of Thoracic Oncology, Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, Jessica S. Donington, MD, Associate Professor, Cardiothoracic Surgery, NYU Medical Center, New York, New York, Elizabeth M. Gore, MD, Professor, Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, Suresh S. Ramalingam, MD, Professor of Hematology and Medical Oncology, Director, Division of Medical Oncology, Assistant Dean for Cancer Research, Emory University School of Medicine, Deputy Director, Winship Cancer Institute, Atlanta, Georgia.

Description: New York : Demos Medical, [2017] | Includes bibliographical references and index.

Identifiers: LCCN 2016039960 | ISBN 9781620700969

Subjects: LCSH: LungsCancer.

Classification: LCC RC280.L8 H342 2017 | DDC 616.99/424dc23 LC record available at https://lccn.loc.gov/2016039960

Printed in the United States of America by McNaughton & Gunn.

16 17 18 19 20 / 5 4 3 2 1

We collectively dedicate this book to the many patients who have taught us so much over the years about strength, determination and perseverance.

To my wife Mary and my boys Peter and John for all their patience and support

Gregory P. Kalemkerian, MD

For Pamela Steiner, my mother, friend, and role model.

Jessica S. Donington, MD

To my husband Stuart Wong and my children Allie, Stuart, Hank, and Russell for their endless support.

Elizabeth M. Gore, MD

To my parents R. Sakkaraiappan and S. Saraswathi, for their support and personal sacrifices, that made my journey possible

Suresh S. Ramalingam, MD

Contents

Contents

Ann G. Schwartz

Charles A. Powell and Vaishnavi Kundel

Edwin R. Parra and Ignacio I. Wistuba

Steven E. Lommatzsch and James Jett

Shirish M. Gadgeel

Jessica S. Donington and Jean Lee

Smitha P. Menon and Elizabeth M. Gore

Conor E. Steuer and Suresh S. Ramalingam

Bryan J. Schneider

Michael F. Gensheimer and Billy W. Loo Jr.

Gregory P. Kalemkerian and James A. Hayman

Vinicius Ernani and Taofeek K. Owonikoko

Ying Wang, Cheryl Ho, and Janessa Laskin

Anish Thomas and Raffit Hassan

Sukhmani K. Padda, Bryan M. Burt, and Heather A. Wakelee

Susan Urba and Joseph A. Bovi

Contributors

Joseph A. Bovi, MD

Associate Professor of Radiation Oncology

Department of Radiation Oncology

Medical College of Wisconsin

Froedtert Memorial Lutheran Hospital

Milwaukee, Wisconsin

Bryan M. Burt, MD

Assistant Professor of Surgery

Division of General Thoracic Surgery

Baylor College of Medicine

Houston, Texas

Jessica S. Donington, MD

Associate Professor

Cardiothoracic Surgery

NYU Medical Center

New York, New York

Vinicius Ernani, MD

Assistant Professor of Medicine

University of Nebraska Medical Center

Omaha, Nebraska

Shirish M. Gadgeel, MD

Professor

Department of Oncology

Karmanos Cancer Institute

Wayne State University School of Medicine

Detroit, Michigan

Michael F. Gensheimer, MD

Instructor of Radiation Oncology

Department of Radiation Oncology

Stanford Cancer Institute

Stanford University School of Medicine

Stanford, California

Elizabeth M. Gore, MD

Professor

Department of Radiation Oncology

Medical College of Wisconsin

Milwaukee, Wisconsin

Raffit Hassan, MD

Senior Investigator

Thoracic and GI Oncology Branch