Liang Cheng - Essentials of Anatomic Pathology
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- Book:Essentials of Anatomic Pathology
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- Publisher:Springer International Publishing
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- Year:2018
- City:Cham
- Rating:3 / 5
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General Pathology
Features | ThinPrep (TP) | SurePath (SP) | Conventional preparation (CP) |
|---|---|---|---|
Sample collection | Uniform head of sampling device is discarded | Uniform head of sampling device is submitted | Uniform head of sampling device is discarded |
Slide preparation | Fully automated | Partially automated | Manual |
Number of cells | ~50,000 | ~50,000 | ~300,000 |
Slide area | Cells in well-defined 20 mm diameter area | Cells in well-defined 13 mm diameter area | Cells diffusely smeared in 2575 mm area |
Image-guided screening | ThinPrep Imaging System | FocalPoint Slide Profiler and FocalPoint Guided Screener | FocalPoint Slide Profiler and FocalPoint Guided Screener |
Fixation | Methanol | Ethanol | Alcohol |
Cell preservation | Good | Good | Variable |
Obscuring factors | None | None | Usually present |
Air-drying | None | None | Usually present |
HPV testing | Testing from vial (FDA approved) | Testing from vial (not FDA approved but can be validated) | Testing from another sample |
- Meta-analysis of prospective randomized trials demonstrated no significant difference between CP and LBC in the detection of CIN2/3 lesions
- LBC offers a cleaner and possibly more efficient cell preparation to review and the ability to perform human papillomavirus (HPV) testing, as well as chlamydia and gonorrhea testing
- ThinPrep Imaging System: 22 fields of vision
- BD FocalPoint Guided Screening Imaging System: 10 fields of vision
- Specimen rejected/not processed (specify reason)
- Specimen processed and examined, but unsatisfactory for evaluation of epithelial abnormality because of (specify reason)
- Squamous metaplasia
- Keratotic changes
- Tubal metaplasia
- Atrophy
- Pregnancy-associated changes
- Inflammation (includes typical repair)
- Lymphocytic (follicular) cervicitis
- Radiation
- Intrauterine contraceptive device (IUD)
- Glandular cells status post-hysterectomy
- (Also specify if negative for squamous intraepithelial lesion)
- Atypical squamous cells
- Of undetermined significance (ASC-US)
- Cannot exclude HSIL (ASC-H)
- With features suspicious for invasion (if invasion is suspected)
- Atypical
- Endocervical cells (NOS or specify in comments)
- Endometrial cells (NOS or specify in comments)
- Glandular cells (NOS or specify in comments)
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