Kuniaki Otsuka - Chronomics and Continuous Ambulatory Blood Pressure Monitoring: Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring

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Living matter is variable in time and space, as is weather. The more constant we try to make our proximal environment, the better we recognize seemingly spontaneous variability that reflects the changes around us, near and far. I describe a journey that started with counts of circulating blood cells and action potentials of our brain and the then-surprising periodicities even in RNA and DNA formation and led to the recognition of the drastic importance of timing, among very many other stimuli, exposure to noise first (and X-irradiation and drugs afterward) in the 1950s. What I had then dubbed circadian stage made the difference between ~70 or 80 % death and ~70 or 80 % survival from the same drug, ouabain, or an adrenocortical inhibitor, respectively, or other stimulus. Eventually, I learned that extracircadian rhythms also needed to be mapped; infradians can determine whether we die suddenly because of cardiac malfunction, by our own hand or by that of others. The cycles of the cosmos are found transdisciplinarily and are a challenge as we try to account for them beyond the molecule, at the levels of atom and quantum, with respect to the ever-present associations with space weather.

A perspective in space gains from new complementary imaging tools, chronobiology and chronomics leading (this is humanitys challenge) to chronobioethics. In having fun toward that goal, we can use a set of linear-nonlinear cosinor methods that, whenever possible, should be applied glocally in time and space: nonstationarities are found not only in geo- (and cosmo-)graphy but also in time, in each case requiring the analyses of the longest available time series as a whole (globally) and in sections varied systematically in length (locally). The resulting atlas, when completed, will, we trust, serve a unified science, providing new preventive and therapeutic marker endpoints for variability anomalies among which coexisting multiple circadian and multiple about-7-day cycles are already mapped and await application for strain relief during wellness. We resonate with the solar flares about 5 months and the solar wind speeds over 1-year-long periods, as well as with decadals (about 10 years), didecadals (about 20 years), paratridecadals (about 35 years), and transsemicentennials (about 600 years) of space weather. These contribute to more than blackouts in and around us, including war and terrorism. The study of space weather is thus relevant to human affairs, including an effect on our mood, long anticipated by Alexander Leonidovich Chizhevsky and indirectly documented by Joseph Vallot, validated herein in the language of shared frequencies and by remove-and-replace approaches whose application has just begun.

Late in 1948, when I arrived at the Peter Bent Brigham Hospital of the Harvard Medical School in Boston, word was that the adrenocortical hormone cortisone, isolated by Edward C. Kendall of the Mayo Clinic (manufactured by the Merck Co.s Lewis H. Sarett, the likely source of information) given by Philip S. Hench to patients with severe rheumatoid arthritis [ shows that 1 g of cortisone was effective in inducing a relative eosinopenia in the ascending stage of the circadian rhythm in eosinophil count in the mice investigated (when a spontaneous decrease in count was most unlikely to occur).