Aaron E. Miller - Neuroimmunology

Lawrence C. Newman, MD

Director of the Headache Division

Professor of Neurology

New York University Langone

New York, New York

Morris Levin, MD

Director of the Headache Center

Professor of Neurology

University of California, San Francisco

San Francisco, California

Headache and Facial Pain

Epilepsy

Neuro-Ophthalmology

Pain

Emergency Neurology

Neuroinfections

Neurogenetics

Neurotology

Pediatric Neurology, Second Edition

Neurocritical Care, Second Edition

Stroke, Second Edition

Peripheral Nerve and Muscle Disease, Second Edition

Cerebrovascular Disease, Second Edition

Movement Disorders, Second Edition

Womens Neurology

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Library of Congress Cataloging-in-Publication Data

Names: Miller, Aaron E., author. | DeAngelis, Tracy M., author. | Fabian, Michelle, author. | Sand, Ilana Katz, author.

Title: Neuroimmunology / by Aaron E. Miller, Tracy M. DeAngelis, Michelle Fabian, Ilana Katz Sand. Other titles: What do I do now?

Description: Second edition. | Oxford ; New York : Oxford University Press, [2018] | Series: What do I do now? | Includes bibliographical references and index.

Identifiers: LCCN 2018009729 | ISBN 9780190693190 (paperback : alk. paper) | ISBN 9780190693213 (epub)

Subjects: | MESH: Demyelinating Diseasesdiagnosis | Demyelinating Diseasestherapy | Neurologic Manifestations | Vasculitis, Central Nervous System | Nervous Systemimmunology | Case Reports

Classification: LCC QP356.47 | NLM WL 141 | DDC 616.97/8dc23

LC record available at https://lccn.loc.gov/2018009729

This material is not intended to be, and should not be considered, a substitute for medical or other professional advice. Treatment for the conditions described in this material is highly dependent on the individual circumstances. And, while this material is designed to offer accurate information with respect to the subject matter covered and to be current as of the time it was written, research and knowledge about medical and health issues is constantly evolving and dose schedules for medications are being revised continually, with new side effects recognized and accounted for regularly. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulation. The publisher and the authors make no representations or warranties to readers, express or implied, as to the accuracy or completeness of this material. Without limiting the foregoing, the publisher and the authors make no representations or warranties as to the accuracy or efficacy of the drug dosages mentioned in the material. The authors and the publisher do not accept, and expressly disclaim, any responsibility for any liability, loss or risk that may be claimed or incurred as a consequence of the use and/or application of any of the contents of this material.

This Book Is Dedicated to

Ellen, whose unwavering support makes everything possible and whose love makes every day a treasure.

AEM

To the memory of Dr. Izabella Rozenfeld, dear Bella, whose knowledge and unbridled passion for neurology guide me still.

TMD

To my mentors, who have given me the priceless gift of their knowledge and time; and to my patients who have trusted me to share the journey of illness with them, and who are so much more than a case in a book.

MTF

To my dad, my first and forever mentor, whom I can always count on for my what do I do now? questions.

IKS

In the six years since the publication of the first edition of Neuroimmunology in the What Do I Do Now? series, novel immunological disorders of the nervous system have been discovered, and understanding of this fascinating class of diseases has burgeoned. New therapies based on large clinical trials for well-known disorders such as MS have proliferated, whereas treatment for less common disorders remains anecdotal, albeit based on increasing experience of experts.

In this second expanded edition of Neuroimmunology, our goal remains to provide a useful framework for clinicians to use when approaching challenging immune-mediated diseases of both the central and peripheral nervous systems. Each chapter begins with a very brief case presentation, including just enough information to challenge your thinking. The subsequent discussions focus on localization, differential diagnosis, and treatment specific to the case and disorder itself. We have presented a range of conditions, including both those frequently encountered such as multiple sclerosis and those much more rarely seen, such as several unique autoimmune encephalopathies. In MS, the availability of new therapies has created a variety of scenarios, only a few of which could be presented in this small volume. Our recommendations for diagnostic testing and therapy rest, whenever possible, on available current evidence, as reflected in the updated key references for this edition. Key clinical points are highlighted in the conclusion of each chapter. In select chapters, tables and figures are provided to illustrate cardinal teaching points such as diagnostic criteria.

We trust this volume will serve as an accessible and practical tool for neurologists and other clinicians, both those in practice and those still in training. We hope it will be an important and useful resource for both clinicians and their patients in helping to facilitate better recognition and management of an ever-increasing number of neurological disorders.

Aaron E. Miller, MD

Tracy M. DeAngelis, MD

Michelle Fabian, MD

Ilana Katz Sand, MD

Many of the cases described in this book have involved challenging presentations of neuroimmunological disorders requiring the expertise and support of a multidisciplinary clinical care team at Mount Sinai Hospital or North Shore University Hospital. These patients have been the subject of extensive discussion among our colleagues at the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai or at Neurological Associates of Long Island. These consummate professionals have all shared their wisdom and experience, in addition to their passionate provision of excellent, compassionate patient care.