Syed A. Rizvi - Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders

Current Clinical Neurology offers a wide range of practical resources for clinical neurologists. Providing evidence-based titles covering the full range of neurologic disorders commonly presented in the clinical setting, the Current Clinical Neurology series covers such topics as multiple sclerosis, Parkinsons Disease and nonmotor dysfunction, seizures, Alzheimers Disease, vascular dementia, sleep disorders, and many others. Series editor Daniel Tarsy, MD, is professor of neurology, Vice Chairman of the Department of Neurology, and Chief of the Movement Disorders division at Beth Israel Deaconness Hospital, Boston, Massachusetts.

More information about this series at http://www.springer.com/series/7630

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Immune activation of the central or peripheral nervous system (CNS or PNS) has been shown to play a key role in the pathogenesis of many neurological disorders. Basic concepts in clinical neuroimmunology have changed significantly during the last 10 years and are constantly evolving. New data has driven treatment concepts for a large number of autoimmune diseases, none more so than multiple sclerosis. As this area of research has become increasingly active and productive, the need for a comprehensive up-to-date second edition of this handbook has become apparent.

Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders (Second Edition) has been written with the clinician in mind and targets residents, fellows, internists, nurse practitioners, as well as general neurologists. The aim of this book is to make recent developments in neuroimmunology accessible to the clinicians who feel daunted by such advances and requires a clear explanation of the scientific and clinical issues. The chapters have been written by experts in their field and been extensively revised and updated. Two new chapters have been added. Part I provides a logical and straightforward overview of neuroimmunology. Part II consists of eight chapters focused on multiple sclerosis and includes a chapter on clinical decision-making and a chapter on vitamin D in MS. Part III has four chapters and focuses on other CNS inflammatory disorders including neuromyelitis optica, ADEM, vasculitis, autoimmune encephalopathies, and immunological aspects of cancer. Part IV includes two chapters that describe autoimmune disorders of the PNS. Part V , the final part, includes a single chapter that focuses on neurologic manifestation of systemic rheumatologic diseases such as systemic lupus erythematosus (SLE), neuro-sarcoidosis, and Behcets. We hope health professionals who are interested in neuroimmunological disorders will find this book useful.

Finally, we would like to thank our contributing authors for their hard work and guidance.

The role of the immune system in the pathophysiology of central and peripheral nervous system disorders continues to be a topic of great interest among clinicians and researchers in the field. As stated by Drs. Rizvi, Cahill, and Coyle, the editors of Clinical Immunology, Second Edition, basic concepts in this field have changed significantly due to a constant evolution of knowledge since the publication of the first edition of this book in 2011. This comprehensive and up-to-date second edition of this useful handbook is therefore a welcome addition to the field.

Clinical Immunology, Second Edition , continues to be written primarily for clinicians in the field and targets general neurologists, internists, fellows, residents, and nurse practitioners. Although clinically oriented, the chapters all include updated authoritative information on new understandings of the basic mechanisms of the disorders being discussed. Section 1 begins with two useful chapters which provide an excellent introduction and overview of clinical neuroimmunology and the principles of immunotherapy. Section 2 covers multiple sclerosis and includes new chapters on clinical decision-making in the management of multiple sclerosis and the role of vitamin D in this disease. Section 3 covers other central nervous system inflammatory disorders, such as neuromyelitis optica, acute disseminated encephalomyelitis, and CNS vasculitis, and a new chapter on paraneoplastic disorders. Section 4 covers immunologic disorders of muscle and peripheral nerve, and Section 5 provides a new chapter concerning the neurologic manifestations of systemic rheumatologic disorders. The readers of this volume will discover that the quantity of new knowledge accumulated in the past 10 years is worthy of this new and highly comprehensive summary of the field.