Lodish Harvey - Molecular Cell Biology, Ninth Edition

The front cover shows two large spherical structures containing few small fluorescent green spheres. The surface of both large spheres is covered by dot-like structures. The page has the title of the book at the top which reads, Molecular Cell Biology - ninth edition. The name of the authors read, Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe.

NINTH EDITION

• Harvey Lodish

• Arnold Berk

• Chris A. Kaiser

• Monty Krieger

• Anthony Bretscher

• Hidde Ploegh

• Kelsey C. Martin

• Michael B. Yaffe

• Angelika Amon

Senior Vice President, STEM: Daryl Fox

Executive Program Director, Life Sciences: Sandy Lindelof

Executive Program Manager: Lisa Lockwood

Executive Marketing Manager: Will Moore

Executive Content Development Manager, STEM: Debbie Hardin

Developmental Editors: Anna Bristow, Maria Lokshin, Susan Moran, Michael Zierler

Executive Project Manager, Content, STEM: Katrina Mangold

Editorial Project Manager: Karen S. Misler

Director of Content, Life Sciences: Jennifer Driscoll Hollis

Senior Media Editor: Cassandra Korsvik

Editorial Assistant: Nathan Livingston

Marketing Assistant: Morgan Psiuk

Director of Content Management Enhancement: Tracey Kuehn

Senior Managing Editor: Lisa Kinne

Senior Content Project Manager: Peter Jacoby

Senior Workflow Project Manager: Paul Rohloff

Director of Design, Content Management: Diana Blume

Design Services Manager: Natasha Wolfe

Cover Design Manager: John Callahan

Cover Designer: Laura De Grasse

Text Designer: Lumina Datamatics, Inc.

Art Manager: Matthew McAdams

Illustrations: Emiko Paul, Adam Steinberg, Troutt Visual Services

Senior Director, Digital Production: Keri deManigold

Senior Media Project Manager: Daniel Comstock

Permissions Manager: Jennifer MacMillan

Photo Editors: Krystyna Borgen, Lumina Datamatics, Inc.

Text Permissions: Michael McCarty

Production Supervisor: Robert Cherry

Composition: Lumina Datamatics, Inc.

ISBN-13: 978-1-319-38360-2 (ePub)

2021, 2016, 2013, 2008 by W. H. Freeman and Company

All rights reserved.

1 2 3 4 5 6 25 24 23 22 21 20

Macmillan Learning

One New York Plaza

Suite 4600

New York, NY 10004-1562

www.macmillanlearning.com

• TO OUR STUDENTS AND TO OUR TEACHERS,

• from whom we continue to learn,

• AND TO OUR FAMILIES,

• for their support, encouragement, and love

HARVEY LODISH is Professor of Biology and Professor of Biological Engineering at the Massachusetts Institute of Technology and a Founding Member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell-membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF- receptors. His laboratory also studies long noncoding RNAs and micro-RNAs that regulate the development and function of hematopoietic cells and adipocytes. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.

ARNOLD BERK holds the UCLA Presidential Chair in Molecular Cell Biology in the Department of Microbiology, Immunology, and Molecular Genetics and is a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription initiation in mammalian cells, focusing in particular on adenovirus regulatory proteins. He teaches an advanced undergraduate course in cell biology of the nucleus and a graduate course in the biochemistry of gene expression.

CHRIS A. KAISER is the Amgen Inc. Professor in the Department of Biology at the Massachusetts Institute of Technology. He is also a former Department Head and former Provost at MIT. His laboratory uses genetic and cell biological methods to understand how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top educator at MIT, where he has taught genetics to undergraduate and graduate students for many years.

MONTY KRIEGER is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology and a Senior Associate Member of the Broad Institute of MIT and Harvard. Dr. Krieger is also a member of the National Academy of Sciences. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for pathogen recognition and the movement of cholesterol into and out of cells, including the HDL receptor.

ANTHONY BRETSCHER is Professor of Cell Biology at Cornell University and a member of the Weill Institute for Cell and Molecular Biology. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic, and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. He is a fellow of the American Academy of Arts and Sciences. Dr. Bretscher teaches cell biology to undergraduates at Cornell University.