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Gerald Litwack - Human Biochemistry

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Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more.

Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

  • Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers
  • Provides a fully updated resource on current research in human and medical biochemistry
  • Includes clinical case studies, applications, chapter summaries and review-based questions
  • Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

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Table of Contents List of tables Tables in Chapter 1 Tables in Chapter 2 - photo 1
Table of Contents
List of tables
  1. Tables in Chapter 1
  2. Tables in Chapter 2
  3. Tables in Chapter 3
  4. Tables in Chapter 4
  5. Tables in Chapter 5
  6. Tables in Chapter 6
  7. Tables in Chapter 7
  8. Tables in Chapter 9
  9. Tables in Chapter 10
  10. Tables in Chapter 11
  11. Tables in Chapter 13
  12. Tables in Chapter 14
  13. Tables in Chapter 15
  14. Tables in Chapter 16
  15. Tables in Chapter 17
  16. Tables in Chapter 18
  17. Tables in Chapter 19
  18. Tables in Chapter 20
  19. Tables in Chapter 21
List of illustrations
  1. Figures in Chapter 1
  2. Figures in Chapter 2
  3. Figures in Chapter 3
  4. Figures in Chapter 4
  5. Figures in Chapter 5
  6. Figures in Chapter 6
  7. Figures in Chapter 7
  8. Figures in Chapter 8
  9. Figures in Chapter 9
  10. Figures in Chapter 10
  11. Figures in Chapter 11
  12. Figures in Chapter 12
  13. Figures in Chapter 13
  14. Figures in Chapter 14
  15. Figures in Chapter 15
  16. Figures in Chapter 16
  17. Figures in Chapter 17
  18. Figures in Chapter 18
  19. Figures in Chapter 19
  20. Figures in Chapter 20
  21. Figures in Chapter 21
  22. Figures in Appendix 4
Landmarks
Table of Contents
Human Biochemistry

Second Edition

Gerald Litwack, PhD

Professor of Molecular & Cellular Medicine and Associate Director, Institute for Regenerative Medicine, Texas A&M University School of Medicine (Retired)

Emeritus Professor, Chair or Founding Chair, Rutgers University, Thomas Jefferson University Kimmel Medical College and the Geisinger Commonwealth School of Medicine, Texas A&M University School of Medicine, Temple, TX, United States

Copyright Academic Press is an imprint of Elsevier 125 London Wall London EC2Y - photo 2

Copyright

Academic Press is an imprint of Elsevier

125 London Wall, London EC2Y 5AS, United Kingdom

525 B Street, Suite 1650, San Diego, CA 92101, United States

50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States

The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom

Copyright 2022 Elsevier Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publishers permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library

Library of Congress Cataloging-in-Publication Data

A catalog record for this book is available from the Library of Congress

ISBN: 978-0-323-85718-5

For Information on all Academic Press publications visit our website at https://www.elsevier.com/books-and-journals

Publisher: Andre Gerhard Wolff

Acquisitions Editor: Peter B. Linsley

Editorial Project Manager: Pat Gonzalez

Production Project Manager: Stalin Viswanathan

Cover Designer: Christian J. Bilbow

Typeset by MPS Limited, Chennai, India

Dedication The book is dedicated to my family About the author Gerald - photo 3

Dedication

The book is dedicated to my family.

About the author
Gerald Gerry Litwack was educated at Hobart College BA with graduate work - photo 4

Gerald (Gerry) Litwack was educated at Hobart College (BA) with graduate work at the University of Wisconsin, Madison (MS and PhD in biochemistry). After spending a summer at the University of Wisconsin as an instructor in a course on enzymes, he sailed to Paris (Liberte) where he spent a year as a postdoctoral fellow of the National Foundation for Infantile Paralysis at the Laboratoire de Chimie Biologique of the Sorbonne. He then became an Assistant Professor of Biochemistry at Rutgers University, later becoming an Associate Professor at the Graduate School of Medicine of the University of Pennsylvania. Future posts took him to the Fels Institute for Cancer Research and Molecular Biology at the Temple University School of Medicine where he was the Laura H. Carnell Professor of Biochemistry and the Deputy Director of the Institute. Later, he was the Chairman of the Department of Biochemistry and Molecular Pharmacology, a Professor of Biochemistry, Vice Dean for Research, and the Director of the Institute for Apoptosis at Thomas Jefferson University Kimmel Medical College with future appointments as a Visiting Scholar at the Geffen School of Medicine at UCLA, the Founding Chair of the Department of Basic Science of the Geisinger Commonwealth School of Medicine, and, as his final position, a Professor of Molecular and Cellular Medicine and the Associate Director of the Institute for Regenerative Medicine at Texas A&M University School of Medicine. Dr. Litwack was a Sabbatical Visitor at the University of California, Berkeley; the University of California, San Francisco; the Courtauld Institute of Biochemistry (London); and the Wistar Institute. He was appointed as the Emeritus Professor and/or Chairman at Rutgers University, Thomas Jefferson University, and Geisinger Commonwealth School of Medicine. He has published more than 350 papers in scientific journals, is named on more than 20 patents, and held numerous editorial positions on biochemical and cancer journals. He has authored 3 textbooks in the areas of biochemistry or endocrinology and has edited more than 65 books. Following his retirement, he lives with his family in Los Angeles where he continues his work as an author and editor and paints in watercolor.

Preface

. Multiple-choice review questions were prepared by myself, while the case-based problems are the contribution of Prof. Sonia Lobo of the Department of Basic Sciences, the Geisinger Commonwealth School of Medicine. I am most grateful for her contributions. She has considerable experience in utilizing problem-based learning in her teaching of medical students. My hope is that these materials will aid students in the health sciences, especially in those institutions that may be moving in the direction of problem-based learning.

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