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Elaine A. Moore - Alzheimers Disease and Infectious Causes: The Theory and Evidence

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With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimers disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimers disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimers patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimers disease. Sources of infection in Alzheimers disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimers disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimers disease.

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Alzheimers Disease and Infectious Causes McFarland Health Topics Living with - photo 1

Alzheimers Disease and Infectious Causes

McFarland Health Topics

Living with Multiple Chemical Sensitivity: Narratives of Coping. Gail McCormick. 2001

Graves Disease: A Practical Guide. Elaine A. Moore with Lisa Moore. 2001

Autoimmune Diseases and Their Environmental Triggers. Elaine A. Moore. 2002

Hepatitis: Causes, Treatments and Resources. Elaine A. Moore. 2006

Arthritis: A Patients Guide. Sharon E. Hohler. 2008

The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders. Elaine A. Moore and Samantha Wilkinson. 2009

Understanding Multiple Chemical Sensitivity: Causes, Effects,Personal Experiences and Resources. Els Valkenburg. 2010

Type 2 Diabetes: Social and Scientific Origins, Medical Complications and Implications for Patients and Others. Andrew Kagan, M.D. 2010

The Amphetamine Debate: The Use of Adderall, Ritalin and Related Drugs for Behavior Modification, Neuroenhancement and Anti-Aging Purposes. Elaine A. Moore. 2011

CCSVI as the Cause of Multiple Sclerosis: The Science Behind the Controversial Theory. Marie A. Rhodes. 2011

Coping with Post-Traumatic Stress Disorder: A Guide for Families, 2d ed. Cheryl A. Roberts. 2011

Living with Insomnia: A Guide to Causes, Effects and Management,with Personal Accounts. Phyllis L. Brodsky and Allen Brodsky. 2011

Caregivers Guide: Care for Yourself While You Care for Your Loved Ones. Sharon E. Hohler. 2012

You and Your Doctor: A Guide to a Healing Relationship,with Physicians Insights. Tania Heller, M.D. 2012

Advances in Graves Disease and Other Hyperthyroid Disorders. Elaine A. Moore with Lisa Marie Moore. 2013

Cancer, Autism and Their Epigenetic Roots. K. John Morrow, Jr. 2014

Living with Bipolar Disorder: A Handbook for Patients and Their Families. Karen R. Brock, M.D. 2014

Cannabis Extracts in Medicine: The Promise of Benefits in Seizure Disorders, Cancer and Other Conditions. Jeffrey Dach, M.D., Elaine A. Moore and Justin Kander. 2015

Managing Hypertension: Tools to Improve Health and Prevent Complications. Sandra A. Moulton. 2016

Mammography and Early Breast Cancer Detection:How Screening Saves Lives. Alan B. Hollingsworth, M.D. 2016

Living with HIV: A Patients Guide, 2d ed. Mark Cichocki, RN. 2017

Central Sensitization and Sensitivity Syndromes: A Handbook for Coping. Amy Titani. 2017

Hurting Like Hell, Living with Gusto: My Battle with Chronic Pain. Victoria Stopp. 2017

Autogenic Training: A Mind-Body Approach to the Treatment of Chronic Pain Syndrome and Stress-Related Disorders, 3d ed. Micah R. Sadigh. 2019

Alzheimers Disease and Infectious Causes: The Theory and Evidence. Elaine A. Moore. 2020

Alzheimers Disease and Infectious Causes
The Theory and Evidence
Elaine A. Moore
McFarland Health Topics

McFarland Company Inc Publishers Jefferson North Carolina This book - photo 2

McFarland & Company, Inc., Publishers

Jefferson, North Carolina

This book is intended as an educational resource and not as a substitute for medical advice.

All illustrations are by Marvin G. Miller.

ISBN (print) 978-1-4766-7861-0 ISBN (ebook) 978-1-4766-3891-1

Library of Congress and British Library cataloguing data are available

Library of Congress Control Number 2020005712

2020 Elaine A. Moore. All rights reserved

No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying or recording, or by any information storage and retrieval system, without permission in writing from the publisher.

Front cover images 2020 Shutterstock

Printed in the United States of America

McFarland & Company, Inc., Publishers

Box 611, Jefferson, North Carolina 28640

www.mcfarlandpub.com

To Rick, Lisa, Brett, Linda, Brooklyn, and Elimy A team

Acknowledgments

Im grateful to my family and friends for encouraging me to write this book and for understanding when research and writing kept me away from other activities. Special thanks are extended to Marv Miller, my dear friend and illustrator, who created all of the images in this book. My thanks are likewise extended to SammyJo Wilkinson and Randal F. Hubbard for their help in wading through an enormous amount of medical literature.

Id also like to thank the many researchers who have worked to elucidate and explain the causes of Alzheimers disease, especially Lawrence Broxmeyer, MD; Steven Gundry, MD; David Perlmutter, MD; Joseph Mercola, MD; Mark Hyman, MD; and Rodney Dietert, PhD. Id also like to express my gratitude to Layla Milholen at McFarland for always being ready to answer my questions and for being patient as I deliberated for two years, waiting to find an important, fascinating, and meaningful topic to research and write about.

Table of Contents
Preface

When my mother was diagnosed with Alzheimers disease (AD) in 1981, there were no effective therapies for this condition and little was known about its causes. As a clinical chemist with an interest in alternative medicine, I bought her various supplements designed to increase acetylcholine levels and improve memory. My pharmacist brother gave her medications intended to help increase cerebral blood flow. None of these therapies helped. Her gerontologist checked her thyroid, vitamin B12, and folate levels and found them to be within the normal range. All we could do was offer comfort and support as her condition deteriorated.

Over the years, I kept up with advances in AD, volunteered at a nursing home for AD patients, and wrote two books on the subject. From scrutinizing the results of studies presented at international conferences, I learned that a lack of exercise, chronic stress, and a high-sugar diet were considered contributing factors to Alzheimers disease. These factors marginally helped to explain the probable causes in my mothers case.

However, in pondering causes, I recalled hearing about the time that my mother was paralyzed for one year when she was six years old. Too many years have passed to determine the cause of this paralysis, but I had to wonder whether my mother had suffered from reactivation of a herpes virus, particularly Cytomegalovirus , or if she had been infected by a variant of the polio virus or contracted Mycobacterium avium from the chickens our family raised. I also considered the DDT trucks that barreled through our neighborhood in the summers and the pollution from the Lake Erie fish we ate.

This past year, when my husband developed Herpes zoster ophthalmicus (HZO), which is a condition of shingles that affects patients eyes, I was surprised and alarmed to find that recent studies showed a strong association with developing AD within five years. However, it was encouraging to learn that while the risk of dementia remains high, treatment with antiviral drugs reduces this risk by a factor of ten.

I was also surprised to learn that numerous viruses, bacteria, spirochetes, and fungi had been found in the brains of patients with AD. Considering that Treponema pallidum has long been known to cause a similar form of dementia in patients with syphilis, the pieces to this intriguing puzzle grew clearer. However, the question remained regarding whether many different microbes caused the neuroinflammation that leads to AD or if one particular organism was the true cause.

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