E. Feldman - Canine and Feline Endocrinology and Reproduction

Canine and Feline Endocrinology and Reproduction

Third Edition

EDWARD C. FELDMAN, DVM

Diplomate, American College of Veterinary Internal Medicine

Professor, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California

RICHARD W. NELSON, DVM

Diplomate, American College of Veterinary Internal Medicine

Professor, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California

Saunders

COPYRIGHT

SAUNDERS

An Imprint of Elsevier

11830 Westline Industrial Drive

St. Louis, Missouri 63146

CANINE AND FELINE ENDOCRINOLOGY AND REPRODUCTION, THIRD EDITION 0-7216-9315-6

Copyright 2004, Elsevier Science (USA). All rights reserved.

), by selecting Customer Support and then Obtaining Permissions.

NOTICE

Companion animal practice is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the licensed prescriber, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the publisher nor the author assumes any liability for any injury and/or damage to persons or property arising from this publication.

Previous editions copyrighted 1996, 1987

Library of Congress Cataloging in Publication Data

Feldman, Edward C.; Nelson, Richard W.

Canine and feline endocrinology and reproduction/Edward C. Feldman, Richard W.

Nelson.3rd ed.

p.; cm.

Includes bibliographical references and index.

ISBN 0-7216-9315-6

1. DogsDiseases. 2. CatsDiseases. 3. DogsEndocrinology. 4. CatsEndocrinology.

5. DogsReproduction. 6. CatsReproduction. I. Nelson, Richard W. (Richard William),

1953-II. Title.

[DNLM: 1. Dog Diseases. 2. Endocrine Diseasesveterinary. 3. Cat Diseases. 4. Genital

Diseases, Femaleveterinary. 5. Genital Diseases, Maleveterinary. SF 992.E53 F312c 2004]

SF992.E53F45 2004

636.708964dc22

2003059096

Acquisitions Editor: Ray Kersey

Developmental Editor: Denise LeMelledo

Publishing Services Manager: Linda McKinley

Senior Project Manager: Jennifer Furey

Designer: Julia Dummitt

Printed in the United States of America.

With 850 illustrations

Last digit is the print number: 9 8 7 6 5 4 3 2 1

DEDICATION

To our colleagues and clients who have provided us with cases and supported our work through the years.

Also, with special thanks to our residents, technicians, and students who have helped perform much of our clinical research and who refuse to allow us to stop searching for answers

ECF & RWN

To Kay, Beth Ann, and Christopher

RWN

To an appreciation for the knowledge that life, like the experience of the long distance runner, is filled with trials of miles and miles of trials.

During the initial years since publishing the second edition of this text, the miles and trials were long uphill battles.

At such times, support and understanding can be a blessing. I dedicate this effort, in part, to my daughters Rhonda and Shaina, who were not judgmental and to my family: Bernie, Jack, Judy, Karen, Rebecca, and Mitchell who were there when I needed them most. Also to my friends who helped level the trail and make the trials tolerable:

Steve, Pat, Lori, Nancy, Jimmy, Mary, Peter, Thelma Lee, Dick, Kay, Jennifer, Stefan,

Chuck, Terri, Eli, Meg, Jamie, Marie, & Aunt Anne.

Most importantly, to Shawn Marie with you the miles were shorter & they sloped gently downhill, the trials became lenient. Thank you for providing the energy that allowed me to complete this task and thank you for teaching me the meaning of beauty, sincerity, and compassion I cherish you so.

ECF

PREFACE

The goal of the third edition of our textbook on canine and feline endocrinology and reproduction is similar to that of the first two editions: to provide veterinarians with a concise but complete source of information on pathophysiology, clinical signs, diagnosis, and treatment of endocrine, metabolic, and reproductive disorders in dogs and cats. The tremendous expansion of information on these diseases since the last edition prevented us from supplying the profession with an edition that represented simple editing and minor revisions. This third edition is, once again, a complete revision of the last edition. We did maintain the format of the first two editions but with significant changes and additions that we believe will enhance the clinical usefulness of this resource.

After glancing at the table of contents, the reader will quickly notice that this textbook has been divided into endocrine and reproductive disorders. Two extremely important new chapters have been added to the endocrine section: one on Feline Hyperadrenocorticism, and the other on Feline Diabetes Mellitus. We have long been aware that cats are not small dogs. As our knowledge base regarding cats and their diseases expands, the need for specific information on pathophysiology, clinical signs, diagnosis, and treatment of feline disease becomes distinct and obvious.

This third edition again attempts to emphasize clinically relevant information. Virtually all other chapters have undergone extensive re-writing and updating of material, provision of new or updated tables, addition of new or updated figures and algorithms, and alterations to previously used algorithms that demonstrate our continuing evolution in understanding how to explain disease processes. This same approach was used in determining how to improve our diagnostic strategies while continuing to make them practical, cost-effective, and expedient. Finally, we continue to examine how veterinarians can better manage each endocrine or reproduction condition to achieve longer and healthier lives for the cats and dogs owned by our clients. Treatment recommendations were consistently developed with practicality, cost-effectiveness, and compassionate care in mind. We never want to underestimate the importance of the history, physical examination, and general clinical status of each canine or feline patient.

We hope this book will be of help to veterinary students, practitioners, interns, residents, breeders, and owners. The development of this textbook provided us with a challenging, informative, and laborious but rewarding task. We do not believe that final answers are provided for any subject. We do hope this textbook provides the reader with complete, current, applicable information on endocrine and reproductive disorders of dogs and cats. We do not claim that the information is presented completely without bias. Indeed, our extensive clinical experience creates bias, which we are convinced provides a positive and well established foundation to our recommendations on diagnostic and management strategies.

A book of this nature cannot be produced without the support of many people. Our families have endured another period where we spent nights, weekends, and spare time completing this dream of creating a useful resource for people we do not know, but with whom we share a common love of animals. We wish to offer a sincere thank you to the editorial and production staffs at Saunders and Elsevier and to JoAnn Adams, Allen Reinero, and the others at the University of CaliforniaDavis who helped in various ways to make the task easier and the product better.