Connon - Bioprocessing for cell based therapies

This edition first published 2017 2017 by John Wiley & Sons, Ltd.

Registered Office

John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial Offices

9600 Garsington Road, Oxford, OX4 2DQ, UK

The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

111 River Street, Hoboken, NJ 07030-5774, USA

For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell.

The right of Che J. Connon to be identified as the author of the editorial material in this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.

Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book.

Limit of Liability/Disclaimer of Warranty: While the publisher and author(s) have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. It is sold on the understanding that the publisher is not engaged in rendering professional services and neither the publisher nor the author shall be liable for damages arising herefrom. If professional advice or other expert assistance is required, the services of a competent professional should be sought.

Library of Congress Cataloging-in-Publication data applied for:

9781118743416

A catalogue record for this book is available from the British Library.

Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.

Cover image: Science Photo Library - STEVE GSCHMEISSNER/Gettyimages

1. Che J. Connon
2. Institute of Genetic Medicine
3. Newcastle University
4. Newcastle upon Tyne
5. UK

1. Karen Coopman
2. Centre for Biological Engineering
3. Loughborough University
4. Leicestershire
5. UK

1. Julian R. De Havilland
2. Cellular Therapies Facility
3. Newcastle University
4. Newcastle upon Tyne
5. UK

1. Paul A. De Sousa
2. Centre for Clinical Brain Sciences and
3. MRC Centre for Regenerative Medicine
4. University of Edinburgh
5. Edinburgh
6. UK

1. Gustavo S. Figueiredo
2. Department of Ophthalmology
3. Royal Victoria Infirmary
4. Newcastle upon Tyne
5. UK

1. Institute of Genetic Medicine
2. Newcastle University
3. Newcastle upon Tyne
4. UK

1. Francisco C. Figueiredo
2. Department of Ophthalmology
3. Royal Victoria Infirmary
4. Newcastle upon Tyne
5. UK

1. Institute of Genetic Medicine
2. Newcastle University
3. Newcastle upon Tyne
4. UK

1. Lucy Foley
2. Centre for Process Innovation Biologics
3. Darlington
4. UK

1. Jason Hamilton
2. Athersys Inc
3. Cleveland, OH
4. USA

1. Lyn Healy
2. Haematopoietic Stem Cell Laboratory
3. The Francis Crick Institute
4. London
5. UK

1. Thomas R. J. Heathman
2. Centre for Biological Engineering
3. Loughborough University
4. Leicestershire
5. UK

1. Christopher J. Hewitt
2. Centre for Biological Engineering
3. Loughborough University
4. Leicestershire
5. UK

1. Aston Medical Research Institue
2. School of Life and Health Sciences
3. Aston University
4. Birmingham
5. UK

1. Marieke A. Hoeve
2. Centre for Clinical Brain Sciences and
3. MRC Centre for Regenerative Medicine
4. University of Edinburgh
5. Edinburgh
6. UK

1. Charles J. Hunt
2. UK Stem Cell Bank
3. Advanced Therapies Division
4. National Institute for Biological Standards and Control
5. Hertfordshire
6. UK

1. Donghui Jing
2. HaoLing Cell Technologies Corporation
3. TEDA
4. Tianjin
5. P.R.China

1. Daniel Kehoe
2. Stem Cell Bioprocessing Group
3. Process Solutions
4. EMD Millipore Corporation
5. Bedford
6. USA

1. Majlinda Lako
2. Institute of Genetic Medicine
3. Newcastle University
4. Newcastle upon Tyne
5. UK

1. Jennifer Man
2. UK Stem Cell Bank
3. Advanced Therapies Division
4. National Institute for Biological Standards and Control
5. Hertfordshire
6. UK

1. John Morris
2. Asymptote Ltd
3. St John's Innovation Centre
4. Cambridge
5. UK

1. Julie Murrell
2. Stem Cell Bioprocessing Group
3. Process Solutions
4. EMD Millipore Corporation
5. Bedford,
6. USA

1. Alvin W. Nienow
2. Centre for Biological Engineering
3. Loughborough University
4. Leicestershire
5. UK

1. Centre for Bioprocess Engineering
2. University of Birmingham
3. UK

1. Qasim A. Rafiq
2. Centre for Biological Engineering
3. Loughborough University
4. Leicestershire
5. UK

1. Aston Medical Research Institue
2. School of Life and Health Sciences
3. Aston University
4. Birmingham
5. UK

1. Glyn N. Stacey
2. UK Stem Cell Bank
3. Advanced Therapies Division
4. National Institute for Biological Standards and Control
5. Hertsfordshire
6. UK

1. Stephen Swioklo
2. Institute of Genetic Medicine
3. Newcastle University
4. Newcastle upon Tyne
5. UK

1. Bart Vaes
2. ReGenesys BVBA
3. Heverlee
4. Belgium

1. Huaqing Wang
2. Department of Medical Oncology
3. Nankai University Cancer Hospital
4. Tianjin Union Medical Center
5. Tianjin
6. P.R.China

1. Stephen Ward
2. Cell and Gene Therapy Catapult
3. Guy's Hospital
4. London
5. UK

1. Michael Whitaker
2. Institute of Cell and Molecular Sciences
3. Newcastle University
4. Newcastle upon Tyne
5. UK

1. Nicholas A. Willoughby
2. Institute of Biological Chemistry
3. Biophysics and Bioengineering
4. School of Engineering and Physical Sciences
5. Heriot-Watt University
6. Edinburgh
7. UK

Cell-based therapy is an exciting and rapidly developing field of medicine for the 21st century. However, this new paradigm brings new challenges in regulation and production, which requires cross-disciplinary approaches and greater collaboration between clinicians, academics and industrial scientists. This new alliance is reflected in the range of disciplines from which the distinguished contributing authors have been drawn to create this book, including Industry (EMD Millipore Corp., Athersys Inc., ReGenesys, Asymptote Ltd), Governmental (Process Innovation Centre Biologics, Cell Therapy Catapult, UK Stem Cell Bank) and Academic Institutions (The Francis Crick Institute, and Newcastle, Birmingham, Loughborough, Aston, Edinburgh and Heriot-Watt universities). Together they represent the cutting edge, industrially focused frontline of bioprocessing for cell-based therapies.