Claire Komives - Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

1. Chapter 1
2. Chapter 2
3. Chapter 4
4. Chapter 6
5. Chapter 7

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 4
5. Chapter 5
6. Chapter 6
7. Chapter 7

Significant advancements in the fields of biology, chemistry, and related disciplines have led to a barrage of major accomplishments in the field of biotechnology. Wiley Series in Biotechnologyand Bioengineering focuses on showcasing these advances in the form of timely, cuttingedge textbooks and reference books that provide a thorough treatment of each respective topic.

Topics of interest to this series include, but are not limited to, protein expression and processing; nanotechnology; molecular engineering and computational biology; environmental sciences; food biotechnology, genomics, proteomics and metabolomics; largescale manufacturing and commercialization of human therapeutics; biomaterials and biosensors; and regenerative medicine. We expect these publications to be of significant interest to the practitioners both in academia and industry. Authors and editors were carefully selected for their recognized expertise and their contributions to the various and farreaching fields of biotechnology.

Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

by Claire Komives (Editor), Weichang Zhou (Editor)

Preparative Chromatography for Separation of Proteins

by Arne Staby, Anurag S. Rathore, Satinder (Sut) Ahuja

Vaccine Development and Manufacturing

by Emily P. Wen (Editor), Ronald Ellis (Editor), Narahari S. Pujar (Editor)

Risk Management Applications in Pharmaceutical and Biopharmaceutical Manufacturing

by Hamid Mollah (Editor), Harold Baseman (Editor), Mike Long (Editor)

Emerging Cancer Therapy: Microbial Approaches and Biotechnological Tools

by Arsenio Fialho (Editor), Ananda Chakrabarty (Editor)

Quality by Design for Biopharmaceuticals: Principles and Case Studies

by Anurag S. Rathore (Editor), Rohin Mhatre (Editor)

Edited by

This edition first published 2019

2019 John Wiley & Sons, Inc.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Claire Komives and Weichang Zhou to be identified as the editors of this work has been asserted in accordance with law.

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In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress CataloginginPublication Data

Names: Komives, Claire, editor. | Zhou, Weichang, 1963- editor.

Title: Bioprocessing technology for production of biopharmaceuticals and

bioproducts / edited by Claire Komives, Weichang Zhou.

Description: First edition. | Hoboken, NJ : John Wiley & Sons, Inc., 2019. |

Series: Wiley series in biotechnology and bioengineering | Includes

bibliographical references and index. |

Identifiers: LCCN 2018036496 (print) | LCCN 2018037472 (ebook) | ISBN

9781119378280 (Adobe PDF) | ISBN 9781119378303 (ePub) | ISBN 9781118361986

(hardback)

Subjects: | MESH: Biological Products--chemistry | Drug Compounding |

Technology, Pharmaceutical | Bioreactors

Classification: LCC RM301.25 (ebook) | LCC RM301.25 (print) | NLM QV 241 |

DDC 615.1/9--dc23

LC record available at https://lccn.loc.gov/2018036496

Cover design by Wiley

Cover image: iStock.com/MiljaPhoto

Sara M. Badenes

Department of Bioengineering and Institute for Bioengineering and Biosciences

Insituto Superior Tcnico

Universidade de Lisboa

Lisboa, Portugal

Giulia Barbieri

Dipartimento de Genetica Molecolare Batterica

Universidad di Pavia

Pavia PV, Italy

Michael Butler

Department of Microbiology

University of Manitoba

Winnipeg, Manitoba, Canada

Joaquim M. S. Cabral

Department of Bioengineering and Institute for Bioengineering and Biosciences

Insituto Superior Tcnico

Universidade de Lisboa

Lisboa, Portugal

Anthony Calabria

DuPont Industrial Biosciences

Palo Alto, CA, USA

Viki Chopda

Department of Chemical Engineering

Indian Institute of Technology Delhi