David E. Hoffman - The Dead Hand: The Untold Story of the Cold War Arms Race and Its Dangerous Legacy

"Science has brought us to a point at which we might look forward with confidence to the conquest of disease and even to a true understanding of the life that animates us. And now we have cracked the atom and released such energies as hitherto only the sun and the stars could generate. But we have used the atom's energies to kill, and now we are fashioning weapons out of our knowledge of disease."

--Theodor Rosebury, Peace or Pestilence:

Biological Warfare and How to Avoid It, 1949

---------- PROLOGUE ----------

I. Epidemic of Mystery

"Are any of your patients dying?" asked Yakov Klipnitzer when he called Margarita Ilyenko on Wednesday, April 4, 1979. She was chief physician at No. 24, a medium-sized, one-hundred-bed hospital in Sverdlovsk, a Soviet industrial metropolis in the Ural Mountains. Her hospital often referred patients to a larger facility, No. 20, where Klipnitzer was chief doctor. Klipnitzer saw two unusual deaths from what looked like severe pneumonia. The patients, he told Ilyenko, were "two of yours." No, Ilyenko told him, she did not know of any deaths. The next day he called again. Klipnitzer was

more persistent. "You still don't have any patients dying?" he asked. Klipnitzer had new deaths with pneumonia-like symptoms. "Who is dying from pneumonia today?" Ilyenko replied, incredulous. "It is very rare."

Soon, patients began to die at Ilyenko's hospital, too. They were brought in ambulances and cars, suffering from high fevers, headaches, coughs, vomiting, chills and chest pains. They were stumbling in the hallways and lying on gurneys. The head of admissions at Hospital No. 20, Roza Gaziyeva, was on duty overnight between April 5

and 6. "Some of them who felt better after first aid tried to go home. They were later found on the streets--the people had lost consciousness," she recalled. She tried to give mouth-to-mouth resuscitation to one ill patient, who died. "During the night, we had four people die. I could hardly wait until morning. I was frightened."

On the morning of April 6, Ilyenko raced to the hospital, threw her bag into her office, put on her white gown and headed for the ward. One patient looked up at her, eyes open, and then died. "There are dead bodies, people still alive, lying together. I thought, this is a nightmare. Something is very, very wrong."

Death came quickly to victims. Ilyenko reported to the district public health board that she had an emergency. Instructions came back to her that another hospital, No. 40, was being set up to receive all the patients in an infectious disease ward. The word spread--infection!--and with it, fear. Some staff refused to report for work, and others already at work refused to go home so as not to expose their families. Then, disinfection workers arrived at hospital No. 20, wearing hazardous materials suits. They spread chlorine everywhere, which was a standard disinfectant, but the scene was terrifying, Ilyenko recalled. "There was panic when people saw them." 1

Sverdlovsk, population 1.2 million, was the tenth-largest city in the Soviet Union and the heartland of its military-industrial complex. Guns, steel, industry and some of the best mechanical engineering schools in the Soviet Union were Sverdlovsk's legacy from Stalin's rush to modernize during World War II and after. Since 1976, the region had been run by a young, ambitious party secretary, Boris Yeltsin.

Hospitals No. 20 and 24 were in the southern end of the city, which slopes downward from the center. Streets lined with small wooden cottages and high fences were broken up by stark five-story apartment buildings, shops and schools. The Chkalovsky district, where Ilyenko's hospital was located, included a ceramics factory where hundreds of men worked in shifts in a cavernous building with large, high windows.

Less than a mile away, to the north-northwest, was Compound 32, an army base for two tank divisions, largely residences, and, adjacent to it, a closed military microbiology facility. Compound 19, which comprised a laboratory, development and testing center for deadly pathogens, including anthrax, was run by the 15th Main Directorate of the Ministry of Defense. On Monday April 2, 1979, from morning until early evening, the wind was blowing down from Compound 19 toward the ceramics factory.2

Inside Compound 19, three shifts operated around the clock, experimenting with anthrax and making it in batches. Anthrax bacteria were grown in fermentation vessels, separated from the liquid growth medium and dried before they were ground up into a fine powder for use in aerosol form. Workers at the compound were regularly given vaccinations. The work was high risk.

Anthrax is an often-fatal infection that occurs when spores of the bacteria Bacillus anthracis enter the body, either through the skin, ingestion or inhalation. The bacteria germinate and release toxins that can quickly bring on death if untreated. In Russia, the disease was known as Sibirskaya yazva, or Siberian ulcer, because of the black sores that form when it is contracted through cuts in the skin. In nature, the disease most commonly spreads through contact with infected animals, usually grazing animals such as cows, goats and sheep, which ingest the spores from the soil. The inhalation variety is dangerous to humans. Breathing the spores into the lungs can kill those infected if not treated. A single gram of anthrax contains around a trillion spores.

Odorless and colorless, the spores are extremely stable, and can remain dormant for as long as fifty years or more. For these reasons, anthrax was well suited for a biological weapon. According to one estimate, 112 pounds of anthrax spores released along a 1.2-mile line upwind of a city of 500,000 residents would result in 125,000

infections--and kill 95,000 people. 3

What exactly happened at Compound 19 is still unknown. By one account, a filter was removed and not properly replaced, and anthrax spores were released into the air.4

To the south, sheep and cattle in villages began to die. Anthrax had been present in rural areas in the past, although it was not common. At the same time, people started getting sick. The first records of those admitted to hospitals came on Wednesday, April 4, when Ilyenko got Klipnitzer's phone call. "What was strange for us, it was mainly men dying, not many women, and not a single child," she said.5 Ilyenko began keeping records of names, ages, addresses and possible reasons for the deaths, but she didn't know what was happening, or why.

On April 10, as the crisis deepened, Faina Abramova, a retired pathologist who had been a lecturer at the Sverdlovsk Medical Institute, was summoned to Hospital No.

40 and asked to autopsy a thirty-seven-year-old man who died over the weekend. He had been at Compound 32, the army base with the tank divisions, for reserve duty, gone home to a nearby village and, for no apparent reason, became suddenly ill.

Abramova, a spirited professional, was puzzled by the case. The man did not show classic signs of influenza and pneumonia. But the autopsy showed infection of the lymph nodes and the lungs. Abramova had also noticed the man suffered from cerebral bleeding, a distinctive red ring around the brain known as "cardinal's cap."6

"We started thinking what other diseases may cause this pathology," she recalled. "We looked up the books, and we went through them all together, and it looked like anthrax."