Eva-Kathrin Ehmoser-Sinner - Lessons on Synthetic Bioarchitectures
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Learning Materials in Biosciences textbooks compactly and concisely discuss a specific biological, biomedical, biochemical, bioengineering or cell biologic topic. The textbooks in this series are based on lectures for upper-level undergraduates, masters and graduate students, presented and written by authoritative figures in the field at leading universities around the globe.
The titles are organized to guide the reader to a deeper understanding of the concepts covered.
Each textbook provides readers with fundamental insights into the subject and prepares them to independently pursue further thinking and research on the topic. Colored figures, step-by-step protocols and take-home messages offer an accessible approach to learning and understanding.
In addition to being designed to benefit students, Learning Materials textbooks represent a valuable tool for lecturers and teachers, helping them to prepare their own respective coursework.
More information about this series at http://www.springernature.com/series/15430
This Springer imprint is published by Springer Nature
The registered company is Springer International Publishing AG
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The online version of this article () contains supplementary material, which is available to authorized users.
The objective of synthetic bioarchitectures as a field of research cannot be confined yet as it belongs to the converging sciences, still emerging; however, let us foresee one of the most relevant objectives of this field: the communication of life with synthetic matter.
What can we learn by talking to nature in the language of molecules? We can interfere with biological pathways in a much more compatible format than has ever been possible before.
For example, thinking about chemotherapy we might apply the German saying: den Teufel mit dem Beelzebub austreibenwhich means that chemotherapy is about trading off: lacking specific tumor markers results in the attempt to stop proliferation in general and the result appears as treating bad with similar bad: we kill various cells in the course of chemotherapy and eventually we succeed by hitting cancerous cells harder than benign tissue. The side effects are of course enormous and undesired.
Cartoon of a (eukaryotic) cell with a graphic inset of an artificial bioarchitecturenamely a membrane protein, which might interfere with a diseased cell. This desired artificial assembly is available in vitro, made by the ribosomal complex with all the compounds needed (translocon machinery, chaperones, etc.) and energetic boundary conditions involved; however, instead of targeting the endoplasmic reticulum, as an example, colloidal membrane architecture can be addressed (e.g., membrane disks). On the other side of the cartoon, the whole organism is depicted, represented by two mice, eventually being cured by the introduction of such synthetic assemblies
As time will tell, eventually, synthetic bioarchitectures will be targeted by scientists as novel therapeutics. (Composition images courtesy of D. Miklavcic, Ljubljana University, Slovenia; Tarek Mounir, CNRS, France; Ute Reuning, Technische Universitt Mnchen, Germany)
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