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Lakhani - WHO classification of tumours of the breast

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World Health Organization Classification of Tumours

Eble J.N., Sauter G., Epstein J.I., Sesterhenn I.A. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (3rd edition).

IARC Press: Lyon 2004

ISBN 92 832 2415 9

Barnes L., Eveson J.W., Reichart P., Sidransky D. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours (3rd edition).

IARC Press: Lyon 2005

ISBN 92 832 2417 5

Fletcher C.D., Unni K.K., Mertens F. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone (3rd edition).

IARC Press: Lyon 2002

ISBN 92 832 2413 2

Travis W.D., Brambilla E., Mller-Hermelink H.K., Harris C.C. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Lung, Pleura, Thymus and Heart (3rd edition).

IARC Press: Lyon 2004

ISBN 92 832 2418 3

LeBoit P.E., Burg G., Weedon D., Sarasin A. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours (3rd edition).

IARC Press: Lyon 2006

ISBN 92 832 2414 0

DeLellis R.A., Lloyd R.V., Heitz, P.U., Eng C. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs (3rd edition).

IARC Press: Lyon 2004

ISBN 92 832 2416 7

Louis D.N., Ohgaki H., Wiestler O.D., Cavenee W.K. (Eds.): World Health Organization Classification of Tumours of the Central Nervous System (4th edition).

IARC: Lyon 2007

ISBN 92 832 2430 2

Swerdlow S.H., Campo S., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J., Vardiman J.W. (Eds): World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues (4th edition).

IARC: Lyon 2008

ISBN 92 832 2431 0

Bosman F.T., Carneiro F., Hruban R.H., Theise N.D. (Eds.): World Health Organization Classification of Tumours of the Digestive System (4th edition)

IARC: Lyon 2010

ISBN 978 92 832 2432 7

This book and all other volumes of the series can be purchased from:

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WHO PRESS

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Tel. +41 22 791 3264

Fax +41 22 791 4857

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Tel. +1 613 745-2665

Fax. +1 613 745-7660

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WHO classification of tumours of the breast - image 1

World Health Organization Classification of Tumours
WHO WHO classification of tumours of the breast - image 2 OMS
International Agency for Research on Cancer (IARC)

4th Edition

WHO Classification of Tumours of the Breast

Edited by

Sunil R. Lakhani

Ian O. Ellis

Stuart J. Schnitt

Puay Hoon Tan

Marc J. van de Vijver

World Health Organization Classification of Tumours Series Editors - photo 3

World Health Organization Classification of Tumours

Series Editors

Fred T. Bosman, MD

Elaine S. Jaffe, MD

Sunil R. Lakhani, MD

Hiroko Ohgaki, PhD

WHO Classification of Tumours of the Breast

Editors

Sunil R. Lakhani, MD

Ian O. Ellis, MD

Stuart J. Schnitt, MD

Puay Hoon Tan, MD

Marc J. van de Vijver, MD, PhD

Technical Editors

Heidi Mattock, PhD

Rachel Purcell, PhD

Layout

Alberto Machado

Delphine Nicolas

Printed by

CHIRAT

42540 Saint-Just-la-Pendue, France

Publisher

International Agency for

Research on Cancer (IARC)

69372 Lyon Cedex 08, France

This volume was produced with support from the

MEDIC Foundation

The WHO Classification of Tumours of the Breast
presented in this book reflects the views of a Working Group
that convened for a Consensus and Editorial Meeting at the
International Agency for Research on Cancer (IARC), Lyon
September 13, 2011.

Members of the Working Group are indicated
in the

Published by the International Agency for Research on Cancer (IARC),
150 cours Albert Thomas, 69372 Lyon Cedex 08, France

International Agency for Research on Cancer, 2012

Distributed by
WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
(Tel: +41 22 791 3264; Fax: +41 22 791 4857; e-mail: ).

Publications of the World Health Organization enjoy copyright protection in accordance
with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.

The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.

The authors alone are responsible for the views expressed in this publication.

The copyright of figures and charts remains with the authors.
(See )

Format for bibliographic citations:

Lakhani S.R., Ellis I.O., Schnitt S.J., Tan P.H., van de Vijver M.J. (Eds.):

WHO Classification of Tumours of the Breast.

IARC: Lyon 2012

IARC Library Cataloguing in Publication Data

WHO classification of tumours of the breast / edited by Sunil R Lakhani ... [et al.] 4th edition

(World Health Organization classification of tumours)

1. Breast Neoplasms genetics 2. Breast Neoplasms classification
3. Breast Neoplasms pathology I. Lakhani, Sunil R. II. Series

ISBN 978-92-832-4488-2

(NLM Classification: WI 1)

Contents
WHO classification of tumours of the breast

EPITHELIAL TUMOURS

8500/3

8022/3

8035/3

8520/3

Classic lobular carcinoma

Solid lobular carcinoma

Alveolar lobular carcinoma

Pleomorphic lobular carcinoma

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