Ichiro Katayama - Evolution of Atopic Dermatitis in the 21st Century

Editors

Ichiro Katayama , Hiroyuki Murota and Takahiro Satoh

Evolution of Atopic Dermatitis in the 21st Century

Editors

Ichiro Katayama

Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Hiroyuki Murota

Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Takahiro Satoh

Department of Dermatology, National Defense Medical College, Tokorosazawa, Saitama, Japan

ISBN 978-981-10-5540-9 e-ISBN 978-981-10-5541-6

https://doi.org/10.1007/978-981-10-5541-6

Library of Congress Control Number: 2017959195

Springer Nature Singapore Pte Ltd. 2018

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Contents

Part I Introduction

Kiyoshi Nishioka

Part II Epidemiology

Takumi Takizawa , Akihiro Morikawa and Hirokazu Arakawa

Yasuyuki Sumikawa

Akiko Kijima , Hiroyuki Murota and Ichiro Katayama

Part III Genetics

Mayumi Tamari and Tomomitsu Hirota

Part IV Etiopathology of AD From Japanese Studies

Hiroyuki Murota , Kosuke Yamaga and Ichiro Katayama

Takashi Hashimoto and Takahiro Satoh

Saeko Nakajima , Tetsuya Honda and Kenji Kabashima

Kenji Izuhara , Satoshi Nunomura , Shoichiro Ohta , Masahiro Ogawa and Yasuhiro Nanri

Hiroyuki Murota and Ichiro Katayama

Tetsuo Shiohara , Yurie Shimoda-Komatsu , Yoshiko Mizukawa , Yuki Hayashida and Yumi Aoyama

Keiji Iwatsuki , Osamu Yamasaki and Shin Morizane

Mayuko Nakano-Tahara , Hiroyuki Murota and Ichiro Katayama

Ichiro Katayama , Kohsuke Yamaga and Hiroyuki Murota

Part V Classification

Yoshiki Tokura

Part VI Clinical Manifestations

Hirokazu Arakawa

Aya Takahashi , Hiroyuki Murota and Ichiro Katayama

Ryoji Tanei

Ichiro Katayama

Part VII Diagnosis

Hidehisa Saeki

Part VIII Management

Takahiro Satoh

Norito Katoh

Yukihiro Ohya

Sakae Kaneko

Hiroyuki Murota and Ichiro Katayama

Ken Igawa and Hiroo Yokozeki

Part IX Complications

Takahiro Tokunaga and Shigeharu Fujieda

Reiko Kishikawa and Akiko Sugiyama

Part X Clinical Questions

Takeshi Nakahara

E1

History of atopic dermatitis is reviewed. Atopic dermatitis was recognized as a chronic relapsing pruritic skin disease and called differently historically. Neurodermite disseminatus and prurigo diathetique are the distinct concepts leading to that of atopic dermatitis. Sulzburger established the concept of atopic eczema/dermatitis by introducing the concept of atopic hypersensitiveness to this skin disease. His idea was now widely accepted. In 1980 a new phenotype of atopic dermatitis appeared to us and was named adult-type atopic dermatitis. The mechanism and pathogenesis have been investigated extensively to define the real figure of this intractable skin disease.

Atopic dermatitis is now one of the most familiar skin diseases among physicians, as well as general population. It is a chronic relapsing pruritic skin disease with characteristic phenotype and persists long to disturb patients quality of life. In the history of dermatology, this disease might be regarded as one of the severe types of eczema or as different skin diseases. The historical record by Suetonius reported that the first emperor of Roman Empire, Augustus, had been suffering from a chronic itchy skin disease complicated with asthmatic symptoms and rhinitis. This description suggests us atopic predisposition in our modern dermatology [].

In 1884 a famous dermatologist, Hebra, described chronic severe pruritic skin lesions localized on the neck and cubital and popliteal fossae and proposed the name mycosis sive eczema flexurarum to this skin disease []. Blocq and Jacquet suggested that neurodermite (neurodermatitis) is a nervous disease in both the somatic and psychiatric senses. They summarized the characteristics of their disease as follows: (1) nervousness including above-normal to unstable emotion, furious, depressive, hysteric, alcoholism, etc., (2) constant itching always preceding the appearance of visible skin lesions, (3) sharp demarcation of the plaque precisely limited to the area of the preceding itching, (4) skin changes arranged concentric zones resembling other dermatoses of nervous origin, (5) absolute dryness of the lesions, and (6) chronicity of its course. They pointed that (7) hypertrophy of the papillae of the cutis was responsible to this skin change.

In 1892 Besnier classified this skin disease into a category of prurigo []. He pointed that it is a distinct skin disease from prurigo de Hebra (dermatite multiforme prurigineuse chronique). Prurigo de Hebra shows that itchy urticarial papules appear to turn into seropapules and then to prurigo-papules on the extensor surface of extremities and trunk of children of early infancy. And it does not show lichenification.