Rajanikant G. K. - IschemiRs: MicroRNAs in Ischemic Stroke: From Basics to Clinics

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MicroRNAs are small endogenous noncoding RNA molecules that function as a regulator of gene expression at the posttranscriptional level. In recent years, the scientific community has witnessed a massive increase in the wealth of knowledge that bridges the microRNA and its strategic role as a biomarker and therapeutic in a wide range of diseases, including ischemic stroke. However, there is still a lack of comprehensive details linking this small RNA molecule to an ischemic stroke, the more preponderant among the two main types of stroke. This monograph is intended as a medium to examine the emerging role of microRNAs in cerebral ischemia. The book addresses topics related to the activity of microRNAs in multiple pathological manifestations of strokes such as oxidative stress, excitotoxicity, cell death trends, their use as a biomarker, diagnostic agents, and currently practiced therapeutic interventions. It also highlights the latest research on how microRNAs help in neuroregeneration during poststroke events, the myriad of computational tools and databases used in microRNA research, and how they modulate other cerebrovascular diseases. The book concludes with a special insight into the potentials of developing microRNA-based therapies for ischemic stroke.

This book is the first of its kind to bring together pieces of puzzle concerning the effect of the microRNAs on the ischemic stroke. Given the vast literature available in public libraries, our book seeks to provide readers with cutting-edge knowledge on microRNA covering various aspects of stroke. This alone makes our book, one that researchers in this area would be pleased to have in their bookshelves. This book can serve as a comprehensive tool for researchers, doctoral and graduate students, and clinicians in the field of miRNA and ischemic stroke and aid in the development of reliable biomarkers and neurotherapeutics by identifying suitable microRNAs.

We would like to thank the Springer team, especially Madhurima Kahali and Selvakumar Rajendran, for their patient, professional, and constant support throughout the production of this book.