Dmitry O. Zharkov - Mechanisms of Genome Protection and Repair

Advances in Experimental Medicine and Biologyprovides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields. provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.

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DNA repair and DNA damage protection is a vibrant field. The past two decades witnessed a transformation of the area from a view mostly concerned with the spontaneous and induced damage and prevention of its consequences to understanding the genomic DNA as a chemically dynamic entity, a subject of targeted and regulated damage, surveillance, and repair toward the cells own ends. It is now hard to find a biochemical process that would not be connected to DNA damage and repair in some way. The early life of DNA repair culminated in the Nobel Prize awarded in 2015 to Tomas Lindahl, Paul Modrich, and Aziz Sancar. The new one is rapidly evolving with many observations, models, and hypotheses yet to be assembled in a consistent network. This volume draws from both sources, covering a wide range of topics, from mechanistic details of DNA repair enzymes to integrated stress responses in animals and plants, in which DNA damage plays a role. As the field has grown tremendously, it is all but impossible to bring all recent significant developments under a single cover. The works collected here were deemed novel, important for translational research, or illuminating connections not often found in the literature.

I am indebted to all contributors and reviewers, whose eagerness and persistence made this book possible. I also thank Springer Nature editorial office for their excellent and timely support. Finally, I express my deepest gratitude to Arthur Grollman, a brilliant scientist and an inspiring mentor, who many years ago introduced me to the wonderful world of DNA repair.