Jörg Reichrath - Notch Signaling in Embryology and Cancer: Notch Signaling in Embryology

Advances in Experimental Medicine and Biologyprovides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This book series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields

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When the American scientist John S. Dexter discovered mutant fruit flies (Drosophila melanogaster) in his research laboratory at Olivet College (Olivet, Michigan) more than a century ago, he could not have expected the tremendous impact that the characteristic notch-wing phenotype (a nick or notch in the wingtip that gave the responsible gene the name Notch) would later have for many fields of biology and medicine, including embryology, genetics, and cancer. During the last decades, a huge mountain of impressive scientific process has convincingly demonstrated that Notch signaling represents one of the most fascinating pathways that govern cellular core processes including cell fate decisions, embryogenesis, and adult tissue homeostasis. Therefore, it is no surprise that the first edition of the bookNotch Signaling in Embryology and Cancer, published by Landes and Springer in 2012 in the prestigious series Advances in Experimental Medicine and Biology, was very successful, for it fulfilled the need to provide a broad audience (ranging from medical students to basic scientists, physicians, and all other healthcare professionals) with up-to-date information in a comprehensive, highly readable format. At this time, it was the benchmark on this topic, with individual chapters being written by highly respected experts in the field. Because of the enormous progress that has been made on this topic in recent years, we have decided that it is now the right time to publish an updated and extended version. The second edition of the abovementioned book has been expanded substantially and consequently has been divided in three separate volumes to include many new chapters. In its different volumes, leading experts in the field present a comprehensive, highly readable overview on selected aspects of three important topics related to Notch signaling, namely, the underlying molecular mechanisms that mediate its biological effects (Volume I), its role in embryogenesis (Volume II), and last but not least its relevance for pathogenesis, progression, prevention, and therapy of cancer (Volume III). This second volume summarizes the fascinating role of this pathway, which was first developed during the evolution in metazoans and was first discovered in the fruit flyDrosophila melanogaster, for embryology. We are convinced that it will be as successful as the previous edition and are very grateful for the willingness of all authors to contribute to this book. We would also like to express our thanks to Murugesan Tamilselvan, Anthony Dunlap, Larissa Albright, and all other members of the Springer staff for their expertise, diligence, and patience in helping us complete this book.

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