David M. Taylor - The Maudsley Prescribing Guidelines in Psychiatry

The Maudsley Prescribing Guidelines in Psychiatry

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13th Edition

David M. Taylor, BSc, MSc, PhD, FFRPS, FRPharmS

Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at Kings College, London, UK

Thomas R. E. Barnes, mbbs, md, FRCPsych, dsc

Emeritus Professor of Clinical Psychiatry at Imperial College London and

joint-head of the Prescribing Observatory for Mental Health at the

Royal College of Psychiatrists Centre for Quality Improvement, London, UK

Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych

Chair of Mood Disorders and Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at Kings College London, UK

Wl LEY Blackwell

This thirteenth edition first published 2018 2018 David M. Taylor

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of David M. Taylor, Thomas R. E. Barnes and Allan H. Young to be identified as the author(s) of this work has been asserted in accordance with law.

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Library of Congress Cataloging-in-Publication Data

Names: Taylor, David M., 1963- author. I Barnes, Thomas R. E., author. I Young, Allan H., 1938- author.

Title: The Maudsley prescribing guidelines in psychiatry / David M. Taylor, Thomas R. E. Barnes, Allan H. Young.

Other titles: Prescribing guidelines in psychiatry

Description: 13th edition. I Hoboken, NJ : Wiley, 2019. I Includes bibliographical references and index. I Identifiers: LCCN 2018013198 (print) I LCCN 2018013542 (ebook) I ISBN 9781119442561 (pdf) I ISBN 9781119442585 (epub) I ISBN 9781119442608 (pbk.) I ISBN 9781119442561 (ePDF)

Subjects: I MESH: Mental Disorders-drug therapy I Psychotropic Drugs-therapeutic use I Psychotropic Drugs-administration & dosage I Psychopharmacology-methods Classification: LCC RC483 (ebook) I LCC RC483 (print) I NLM WM 402 I DDC 616.89/18^c23 LC record available at https://lccn.loc.gov/2018013198

Cover design by Wiley

Set in 10/12pt Sabon by SPi Global, Pondicherry, India 1 2018

For this 13th edition of The Maudsley Prescribing Guidelines in Psychiatry I am honoured to welcome Thomas Barnes and Allan Young as co-authors. Thomas and Allan are of course internationally renowned for their expertise in the treatment of psychosis and mood disorders, respectively. They take over from Carol Paton, who has edged perceptibly towards retirement, and Shitij Kapur, who has moved on to become the Dean of the faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne. My sincere and substantial gratitude is due to Carol and Shitij for their considerable contributions to several previous editions of The Guidelines. Carol in particular has written a great many sections (reflecting her very wide knowledge) and has been an honest and candid critic of submissions from me and other contributors.

The Guidelines have grown somewhat organically since they were first produced as a 16-page pamphlet in 1994. For this edition we have reorganised sections into 14 chapters, each consisting of a more or less consistent theme of subject areas. Tables listing licensed uses and doses of antidepressants (a relic from the very first edition) have been removed - this information is readily available elsewhere - and new sections have been added. These include antipsychotics and thromboembolism, ECT augmentation of antipsychotics, psychotropics after bariatric surgery and re-starting psychotropics after a period of non-compliance. Although we have tried to a great extent to limit the length of each section and the number of references cited, this edition is inevitably bigger than the last. In order to maintain some semblance of portability, we have reduced by one notch the weight of paper used. The increase in size and weight will be of no significance to the increasing numbers who use The Guidelines as an app or (more rarely these days) as a pdf.

The Guidelines originated as a local document and gradually grew in size and scope into a reference used throughout the UK. More recent editions have been translated into several languages, including Japanese and Chinese, and The Guidelines have seen increased use in other English-speaking countries, particularly the USA. Because of this we have tried more than ever in this edition to make The Guidelines of worldwide relevance by including advice on the use of a range of psychotropics commonly prescribed in countries outside the UK.

The clinical validity of The Guidelines depends to a great extent on expert contributions from a broad array of specialist psychiatrists and pharmacists. I extend my heartfelt thanks to these colleagues, listed in the Acknowledgements section that follows. I would like to express particular gratitude to Shubhra Mace, Ian Osbourne and Siobhan Gee who have made numerous and excellent contributions to this edition. Special thanks are also rightly due to Maria OHagan and Sandy Chang, Managing Editors of this 13th edition of The Guidelines.

David M. Taylor London March 2018

The following have contributed to the Guidelines in Psychiatry.

Andrea Danese Anne Connolly Anthony Cleare Argyris Stringaris Bruce Clark Cristal Oxley Daniel Harwood Daniel Hayes Darren Schwartz David Game David McLaughlin David Veale Deborah Robson Delia Bishara Emily Finch Emmert Roberts Eromona Whiskey Farinaz Keshavarzi Flora Coker Georgina Boon Gordana Milavic Hind Kalifeh Hubertus Himmerich Ian Osborne