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Drew Provan - Oxford Handbook of Clinical and Laboratory Investigation

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Drew Provan Oxford Handbook of Clinical and Laboratory Investigation
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Quick Reference Material Adult normal ranges Haematology Hb 130180gdL - photo 1
Quick Reference Material
Adult normal ranges
Haematology
Hb13.018.0g/dL ()
11.516.5g/dL ()
Haematocrit0.400.52 ()
0.360.47 ()
RCC4.56.5 1012/L ()
3.85.8 1012/L ()
MCV7795fL
MCH27.032.0pg
MCHC32.036.0g/dL
WBC4.011.0 109/L
Neutrophils2.07.5 109/L
Lymphocytes1.54.5 109/L
Eosinophils0.040.4 109/L
Basophils0.00.1 109/L
Monocytes0.20.8 109/L
Platelets150400 109/L
Reticulocytes0.52.5% (or 50100 109/L)
ESR212mm/ 1st hour (Westergren)
Serum B12150700ng/ L
Serum folate2.011.0g/L
Red cell folate150700g/L
Serum ferritin15300g/L (varies with sex and age)
14200g/L (premenopausal )
INR0.81.2
PT12.014.0s
APTT ratio0.81.2
APTT26.033.5s
Fibrinogen2.04.0g/L
Thrombin time3s of control
XDPs<250g/L
Factors II, V, VIII, IX, X, XI,50150IU/dL
RiCoF45150IU/dL
vWF Ag50150IU/dL
Protein C80135U/dL
Protein S80135U/dL
Antithrombin80120U/dL
APCR2.124.0
Bleeding time39min
Biochemistry
Serum urea3.06.5mmol/L
Serum creatinine60125mol/L
Serum sodium135145mmol/L
Serum potassium3.55.0mmol/L
Serum chloride97107mmol/L
Serum bicarbonate2029mmol/L
Serum albumin3250g/L
Serum bilirubin<17mol/L
Serum alkaline phosphatase100300IU/L
Serum calcium2.152.55mmol/L
Serum LDH200450IU/L
Serum phosphate0.71.5mmol/L
Serum urate0.140.46mmol/L
Serum total protein6380g/L
Serum GT1046IU/L
Serum iron1433mol/L ()
1128mol/L ()
Serum TIBC4575mol/L
Serum ALT542IU/L
Serum AST542IU/L
Serum free T4924pmol/L
Serum TSH0.355.5mU/L
Immunology
IgG5.815.4g/L
IgA0.642.97g/L
IgM0.52.0g/L
Complement
C30.681.8g/L
C40.180.6g/L
C1 esterase0.180.54g/L
CH10080120%
C-reactive protein<6mg/L
Serum 2-microglobulin1.03.0mg/L
CGF protein
IgG0.0130.035g/L
Albumin0.1700.238g/L
Urine protein
Total protein<150mg/24h
Albumin (24h)<20mg/24h

Adapted from Provanet al. (1998) Oxford Handbook of Clinical Haematology, Oxford University Press, Oxford (with permission).

Paediatric normal ranges
Haemostasis
ParameterNeonateAdult level
Platelet count150400 109/LAs adult
PTFew seconds longer than adultUp to 1 week
APTTUp to 25%By 29 months
Thrombin timeAs adult
Bleeding time210minAs adult
Fibrinogen2.04.0g/LAs adult
Vitamin K-dependent factors
Factor II3050% adult levelUp to 6 months
Factor VII3050% adult levelBy 1 month
Factor IX2050% adult levelUp to 6 months
Factor X3050% adult levelUp to 6 months
Factor VAs adult
Factor VIIIVariable: 50200% adult level
vW factorUsually raised (up to 3 adult level)
Factor XI2050% adult level612 months
Factor XII2050% adult level36 months
Factor XIII50100% adult level1 month
FDP/XDPUp to twice adult levelBy 7 days
AT5080% adult level612 months
Protein C3050% adult levelUp to 24 months
Protein S3050% adult level36 months
Plasminogen3080% adult level2 weeks

Adapted from Provan et al. (1998) Oxford Handbook of Clinical Haematology, Oxford University Press, Oxford (with permission).

Normal FBC values at various ages from birth to 12 years
AgeHb (g/dL)Hct (L/L)MCV (fL)WBC ( 109/L)Neutrophils ( 109/L)Lymphocytes ( 109/L)
Birth cord blood13.519.50.420.6098118930.0626211.0
13 days16.021.00.450.67951219.434.0521211.5
1 week15.219.80.420.6688126521.01.5010217.0
2 weeks14.019.00.390.6386124520.019.5217.0
1 month11.916.10.310.5585123519.519.02.516.5
26 months10.512.50.280.4286102617.518.5413.5
0.52 years10.513.50.330.397086617.51.58.5410.5
26 years11.513.50.340.4075875.515.51.58.528.00
612 years11.515.50.350.4577954.513.51.58.01.56.80

* Guidelines only: wide range in first weeks of life. Platelet count as adult.

Reference: Hinchliffe & Lilleyman, eds (1987) Practical Paediatric Haematology, John Wiley & Sons, Chichester.

Adapted from Provan et al. (1998) Oxford Handbook of Clinical Haematology, Oxford University Press, Oxford (with permission).

OXFORD MEDICAL PUBLICATIONS
Oxford Handbook of
Clinical and Laboratory Investigation

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