Pamela Flood - Stoeltings Pharmacology & Physiology in Anesthetic Practice

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Sixth Edition

Copyright 2022 Wolters Kluwer.

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Library of Congress Cataloging-in-Publication Data

Names: Flood, Pamela, 1963- editor. | Rathmell, James P., editor. | Urman, Richard D., editor.

Title: Stoeltings pharmacology & physiology in anesthetic practice / [edited by] Pamela Flood, James P. Rathmell, Richard D. Urman.

Other titles: Stoeltings pharmacology and physiology in anesthetic practice. | Stoeltings pharmacology and physiology in anesthetic practice

Description: Sixth edition. | Philadelphia : Wolters Kluwer, [2022] | Preceded by: Stoeltings pharmacology and physiology in anesthetic practice. Fifth edition. 2015. | Includes bibliographical references and indexes.

Identifiers: LCCN 2020052843 | ISBN 9781975126896 (hardback) | ISBN 9781975126919 (epub) | ISBN 9781975126926

Subjects: MESH: Anestheticspharmacology | Physiological Phenomena

Classification: LCC RD82.2 | NLM QV 81 | DDC 615.7/81dc23

LC record available at https://lccn.loc.gov/2020052843

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My coauthors and I dedicate this sixth edition of Stoeltings Pharmacology & Physiology in Anesthetic Practice to our dear colleague, coauthor, and friend, Dr. Mohamed A. Naguib, who passed away in 2020 at the age of 68 years.

Mohamed was a clinical anesthesiologist, a National Institutes of Healthfunded basic scientist, and an entrepreneur who founded a company to develop new therapies for neuropathic pain based on his research. He was the mentor of record to many, including some of his coauthors in this edition. He was an unofficial mentor to countless others, including nearly the entire community of clinical pharmacologists in anesthesia.

You have likely read at least some of his more than 400 scientific papers and many books and book chapters. Mohameds seven (!) chapters in the sixth edition of Stoeltings Pharmacology & Physiology in Anesthetic Practice reflect his academic rigor and clear writing. They also reflect his dedication to teaching; Mohamed was the first author to complete his chapters for this edition. His chapters in this edition reflect his academic breadth, ranging from analgesic pharmacology to neuromuscular physiology.

Those of you who were fortunate to know Mohamed will miss his enthusiasm for science, ready smile, and dry wit. I fondly recall discussing his elegant study of the mechanism that underlies anesthetic-induced cognitive dysfunction in neonatal rats. This is among my favorite papers in the anesthesiology literature. Mohamed demonstrated that the neurologic deficit in development induced by anesthesia in neonatal rats could be reversed with an enriched environment.

Sitting at a back table at a meeting on anesthetic mechanisms, Mohamed described how he created an enriched environment for a rat. How did he know what a baby rat would find entertaining? He leveraged his experience as a parent, creating a playroom for his baby rats. He placed a play group of six baby rats in a large space (preschool) and filled it with toys including running wheels and fun stuff for the rats to explore. Our discussion broke down into laughter about his baby rat playroom, with both of us concluding it might be more fun than the meeting we were attending. We were laughing so hard that we disrupted the speaker! Oops...

That was the last time I saw Mohamed.

Mohameds scholarship, intellectual rigor, and ability to clearly explain complex concepts are fully evident in this edition of Stoeltings Pharmacology & Physiology in Anesthetic Practice . We will miss this amazing clinician, scientist, teacher, and friend.

Pamela Flood, MD, MA

Cassandra Bailey, MB BCh

Assistant Professor

Department of Anesthesiology

University of Cincinnati

Cincinnati, Ohio

Ardin S. Berger, DO

Assistant Professor

Department of Anesthesiology, Perioperative and Pain Management

Stanford University School of Medicine

Stanford Childrens Health

Stanford, California

Bihua Bie, PhD

Research Associate

Anesthesiology Institute

Cleveland Clinic

Cleveland, Ohio

Bianca Bromberger, MD

Resident

Department of Surgery

Columbia University Vagelos College of Physicians and Surgeons

Department of Surgery

NewYork-Presbyterian Hospital

New York, New York

Mark Alexander Burbridge, MD

Clinical Assistant Professor

Department of Anesthesiology, Perioperative and Pain Medicine

Stanford University School of Medicine

Attending Physician

Department of Anesthesiology, Perioperative and Pain Medicine