Mahendra Rai (editor) - Nanotechnology in Medicine: Toxicity and Safety

1. Chapter 1
2. Chapter 2
3. Chapter 4
4. Chapter 5
5. Chapter 6
6. Chapter 7
7. Chapter 8
8. Chapter 9
9. Chapter 10
10. Chapter 11
11. Chapter 12
12. Chapter 13
13. Chapter 14
14. Chapter 15
15. Chapter 16
16. Chapter 17

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 4
5. Chapter 5
6. Chapter 6
7. Chapter 7
8. Chapter 8
9. Chapter 9
10. Chapter 10
11. Chapter 11
12. Chapter 12
13. Chapter 13
14. Chapter 14
15. Chapter 15
16. Chapter 16
17. Chapter 17

Edited by

Mahendra Rai

Sant Gadge Baba Amravati University Maharashtra, India

Mrunali Patel

Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology Changa, Gujarat, India

Rashmin Patel

Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology Changa, Gujarat, India

This edition first published 2022
2022 John Wiley & Sons Ltd

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The right of Mahendra Rai, Mrunali Patel, and Rashmin Patel, to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

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Library of Congress CataloginginPublication Data
Names: Rai, Mahendra, editor. | Patel, Mrunali Rashmin, 1981 editor. | Patel, Rashmin Bharatbhai, 1979 editor.
Title: Nanotechnology in medicine : toxicity and safety / edited by Mahendra Kumar Rai, SGB Amravati University, Maharashtra, India, Mrunali Rashmin Patel, Charotar University of Science and Technology, Gujarat, India, Rashmin Bharatbhai Patel, Charotar University of Science and Technology, Gujarat, India.
Description: Hoboken, NJ : WileyBlackwell, 2022. | Includes bibliographical references and index.
Identifiers: LCCN 2021031539 (print) | LCCN 2021031540 (ebook) | ISBN 9781119769866 (cloth) | ISBN 9781119769873 (adobe pdf) | ISBN 9781119769880 (epub)
Subjects: LCSH: Nanotechnology. | Medical technology.
Classification: LCC R857.N34 N3617 2022 (print) | LCC R857.N34 (ebook) | DDC 610.285dc23
LC record available at https://lccn.loc.gov/2021031539
LC ebook record available at https://lccn.loc.gov/2021031540

Cover Design: Wiley
Cover Image: KATERYNA KON/Getty

Currently, an exceptional growth in research, innovation, and applications have been realized in the area of nanoscience and nanotechnology. Nanotechnology is beheld as a transformative technology. It offers ample possibilities to address the key societal challenges essential to encounter global healthcare problems. It presents engineered nanomaterials, smart innovative products incorporating these materials, and nanoenabled processes having magnificent growth potential for a large number of industrial sectors. Formulation scientists have extensively used nanoparticles for entrapment of drugs with intention of enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to nontarget organs. There is collective optimism that nanotechnology, as applied to medicine, has and will further lead to noteworthy developments in therapeutics, tissue engineering, active implants, nanorobotic biosensors, molecular diagnostics and imaging, bone grafting, tiny vehicles for drug delivery, nutraceuticals, genomics, and proteomics. Nanomedicine, incorporating prospective drug delivery nanocarriers, hails great promises to combat complex illnesses like cancer, neurological diseases, infectious or inflammatory diseases, and malaria due to novel physicochemical properties. However, this may damage and exert toxicological effects due to detrimental interfaces with living systems and the environment. Thus, the smart and sustainable development of these nanomaterials has created concerns about their possible undesirable effects on human health and safety as well as an environmental burden. Additionally, these necessitate contemplating its characteristic features, exposure effects, hazard mechanisms, risk assessment and management.

This book focuses on current trends to deliver therapeutic agents into targeted specific cells, cellular compartments, tissues, and organs by using nanoparticulate carriers; applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nanonutraceuticals, dermatology, gene therapy, etc.; nanotoxicology with focus on nanomedicine, landscapes of