Kenneth Alibek - Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century
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Since the terrorist attack on the United States on September 11, 2001 and subsequent cases of anthrax in Florida and New York City, attention has been focused on the threat of b- logical warfare and bioterrorism. Biological warfare agents are de?ned as living org- isms, whatever their nature, or infected material derived from them, which are used for h- tile purposes and intended to cause disease or death in man, animals and plants, and depend for their efforts on the ability to multiply in person, animal or plant attacked. Biological warfare agents may be well suited for bioterrorism to create havoc and terror in a civilian population, because they are cheap and easy to obtain and dispense. Infectious or contagious diseases have played a major part in the history of warfare deliberately or inadvertently in restricting or assisting invading armies over the centuries. In 1346, the Tartars catapulted plaque-infected bodies into Kaffa in the Crimea to end a 3-year siege. Blankets contaminated with smallpox to infect North American Indians were used by British forces in the 18th century. More recently, the Japanese released ?eas infected with plaque in Chinese cities in the 1930s and 1940s. Biological research programs for both offensive and defensive strategies have been developed by the United States, Britain, the former Soviet Union, and Canada; several other nations are thought to have such programs.
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Series Editor: I. W. Fong
Professor of Medicine, University of Toronto
Head of Infectious Diseases, St. Michaels Hospital
Recent volumes in this series:
INFECTIONS AND THE CARDIOVASCULAR SYSTEM: New Perspectives Edited by I. W. Fong
REEMERGENCE OF ESTABLISHED PATHOGENS IN THE 21 ST CENTURY Edited by I. W. Fong and Karl Drlica
BIOTERRORISM AND INFECTIOUS AGENTS: A New Dilemma for the 21st Century Edited by I. W. Fong and Kenneth Alibek
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information, please contact the publisher.
Edited by
University of Toronto, St. Michael's Hospital Toronto, Ontario, Canada
and
The National Center for Biodefense George Mason University Manassas, Virginia
Editors
I.W. Fong Kenneth Alibek University of Toronto Department of Medical Microbiology 30 Bond Street and Immunology Room 4179W George Mason Universuty Toronto, ON M5B 1W8 National Center for Biodefense Canada 10900 University Blvd.
Manassas, VA 20110 MS 1A8 USA
ISBN 978-1-4419-1265-7 e-ISBN 978-1-4419-1266-4 DOI 10.1007/978-1-4419-1266-4Springer Dordrecht Heidelberg London New York
Library of Congress Control Number: 2009932897
Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permis sion of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
Kenneth Alibek The National Center for Biodefense, George Mason University, Manassas, VA
Harvey Artsob National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Thomas P. Bleck Neurological Surgery and Internal Medicine, and Neuroscience Intensive Care Unit, Charlottesville, VA
George W. Christopher Wilford Hall Air Force Medical Center, Lackland Air Force Base, TX
Theodore J. Cieslak San Antonio Military Pediatric Center, San Antonio, TX
David Allan Brett Dance Health Protection Agency, Department of Microbiology, Derriford Hospital, Plymouth, Devon, UK
David T. Dennis Division Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA
Edward M. Eitzen, Jr. Department of Health and Human Services, Washington, DC
Heinz Feldmann National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Ignatius W. Fong University of Toronto, St. Michaels Hospital, Toronto, Ontario, Canada Allison Groseth National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Lisa Hodges Infectious Diseases Section, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA
Steven Jones National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Immunology, University of Manitoba, Winnipeg, Canada
J. Michael Lane Smallpox Eradication Program, Centers for Disease Control and Prevention,
Atlanta, GA Catherine Lobanova The National Center for Biodefense, George Mason University, Manassas, VA
Maor Maman Israel Defense Forces Medical Corps Headquarters, Israel
Martin I. Metzer Office of Surveillance, Office of the Director, National Center for Infec tious Diseases, Centers for Disease Control and Prevention, Atlanta, GA Robert L. Penn Department of Medicine, Louisiana State University Health Sciences
Center, Shreveport, LA Serguei Popov National Center for Biodefense, George Mason University, Manassas, VA Lila Summer A Human Writes, Atlanta, GA Yoav Yehezkelli Israel Defense Forces Medical Corps Headquarters, Israel
Since the terrorist attack on the United States on September 11, 2001 and subsequent cases of anthrax in Florida and New York City, attention has been focused on the threat of bio logical warfare and bioterrorism. Biological warfare agents are defined as living organisms, whatever their nature, or infected material derived from them, which are used for hostile purposes and intended to cause disease or death in man, animals and plants, and depend for their efforts on the ability to multiply in person, animal or plant attacked. Biological warfare agents may be well suited for bioterrorism to create havoc and terror in a civilian population, because they are cheap and easy to obtain and dispense.
Infectious or contagious diseases have played a major part in the history of warfare deliberately or inadvertently in restricting or assisting invading armies over the centuries. In 1346, the Tartars catapulted plaque-infected bodies into Kaffa in the Crimea to end a 3-year siege. Blankets contaminated with smallpox to infect North American Indians were used by British forces in the 18th century. More recently, the Japanese released fleas infected with plaque in Chinese cities in the 1930s and 1940s.
Biological research programs for both offensive and defensive strategies have been developed by the United States, Britain, the former Soviet Union, and Canada; several other nations are thought to have such programs.
Thus, it is important that physicians and health care personnel on the front line (Emergency physicians, Public Health personnel, Internists, Infectious Disease specialists, Microbiologists, Critical care specialists, and even General practitioners) be aware of the clinical manifestations, diagnosis, and management of these potentially deadly diseases. Awareness is the key to recognition of a bioterrorism attack. Thus, this volume will provide health care workers with up-to-date important reviews by world-renowned experts on infectious and biological agents that could be used for bioterrorism.
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