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Scott Stern - Symptom to Diagnosis An Evidence Based Guide, Third Edition

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Learn the diagnostic process in internal medicine with this engaging, case-based approach

Symptom to Diagnosis teaches you an evidence-based, step-by-step process for evaluating, diagnosing, and treating patients based on their clinical complaints. By applying this process, you will be able to recognize specific diseases and prescribe the most effective therapy.

Each chapter addresses one common complaint and begins with a case and guidance on how to organize the differential diagnosis. As the case progresses, clinical reasoning is explained in detail. The differential diagnosis for that particular case is summarized in tables that highlight the clinical clues and important tests for the leading diagnostic hypothesis and alternative diagnostic hypotheses. As the chapter progresses, the pertinent diseases are reviewed. Just as in real life, the case unfolds in a stepwise fashion as tests are performed and diagnoses are confirmed or refuted.

The third edition is enhanced by the addition of five new chapters--Bleeding Disorders, Dysuria, Hematuria, Hypotension, and Sore Throat--as well as a greater emphasis on how to master the process of working from patient level data (signs, symptoms, and laboratory tests). All chapters incorporate the latest research resulting in new and refined approaches to common symptoms encountered in clinical medicine.

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Copyright 2015 by McGraw-Hill Education. All rights reserved. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher.

ISBN: 978-0-07-180345-8
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Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.


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THE WORK IS PROVIDED AS IS. MCGRAW-HILL EDUCATION AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES AS TO THE ACCURACY, ADEQUACY OR COMPLETENESS OF OR RESULTS TO BE OBTAINED FROM USING THE WORK, INCLUDING ANY INFORMATION THAT CAN BE ACCESSED THROUGH THE WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY DISCLAIM ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. McGraw-Hill Education and its licensors do not warrant or guarantee that the functions contained in the work will meet your requirements or that its operation will be uninterrupted or error free. Neither McGraw-Hill Education nor its licensors shall be liable to you or anyone else for any inaccuracy, error or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill Education has no responsibility for the content of any information accessed through the work. Under no circumstances shall McGraw-Hill Education and/or its licensors be liable for any indirect, incidental, special, punitive, consequential or similar damages that result from the use of or inability to use the work, even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim or cause whatsoever whether such claim or cause arises in contract, tort or otherwise.

In memory of Kim Michele Stern
Scott Stern

For Sarah, Ben, and Amelia
Adam Cifu

In memory of my father, Robert Seidman
Diane Altkorn

Contents
Contributing Authors

Jean-Luc Benoit, MD

Associate Professor of Medicine

Section of Infectious Diseases and Global Health

University of Chicago

Chicago, Illinois

AIDS/HIV Infection

Philip Hoffman, MD

Professor of Medicine

Section of Hematology-Oncology

University of Chicago

Chicago, Illinois

Bleeding Disorders

(Coauthored with Diane Altkorn)

Matthew Kalscheur, MD

Cardiovascular Medicine Fellow

University of Wisconsin Hospital and Clinics

Madison, Wisconsin

Hypotension

(Coauthored with Scott Stern)

Wei Wei Lee, MD

Assistant Professor of Medicine

Section of General Medicine

University of Chicago

Chicago, Illinois

Sore Throat

(Coauthored with Adam Cifu)

Amber Pincavage, MD

Assistant Professor of Medicine

Section of General Medicine

University of Chicago

Chicago, Illinois

Dysuria

(Coauthored with Adam Cifu)

Elizabeth Schulwolf, MD

Assistant Professor of Medicine

Division of Hospital Medicine

Loyola University Medical Center

Maywood, Illinois

Screening and Health Maintenance

(Coauthored with Diane Altkorn)

Sachin Shah, MD

Assistant Professor of Medicine

Section of General Medicine

University of Chicago

Chicago, Illinois

Hematuria

(Coauthored with Diane Altkorn)

Sarah Stein, MD

Associate Professor of Medicine

Section of Dermatology

University of Chicago

Chicago, Illinois

Rash

(Coauthored with Adam Cifu)

Preface

Our goal in creating Symptom to Diagnosis was to develop an interesting, practical, and informative approach to teaching the diagnostic process in internal medicine. Interesting, because real patient cases are integrated within each chapter, complementing what can otherwise be dry and soporific. Informative, because Symptom to Diagnosis articulates the most difficult process in becoming a physician: making an accurate diagnosis. Many other textbooks describe diseases, but fail to characterize the process that leads from patient presentation to diagnosis. Although students can, and often do, learn this process through intuition and experience without direct instruction, we believe that diagnostic reasoning is a difficult task that can be deciphered and made easier for students. Furthermore, in many books the description of the disease is oversimplified, and the available evidence on the predictive value of symptoms, signs, and diagnostic test results is not included. Teaching based on the classic presentation often fails to help less experienced physicians recognize the common, but atypical presentation. This oversight, combined with a lack of knowledge of test characteristics, often leads to prematurely dismissing diagnoses.

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