David Male - Immunology: An Illustrated Outline

Immunology:

An Illustrated Outline

Fifth Edition

David Male

2014 by Garland Science, Taylor & Francis Group, LLC

This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any meansgraphic, electronic, or mechanical, including photocopying, recording, taping, or information storage and retrieval systemswithout permission of the copyright holder.

ISBN 978-0-8153-4501-5

Library of Congress Cataloging-in-Publication Data

Male, David K., 1954

Immunology : an illustrated outline / David Male. -- Fifth edition.

pages cm

Includes bibliographical references and index.

ISBN 978-0-8153-4501-5 (pbk.)

1. Immunology--Outlines, syllabi, etc. 2. Clinical immunology-- Outlines, syllabi, etc. I. Title.

QR182.55.M35 2014

616.07'9--dc23

2013018416

Published by Garland Science, Taylor & Francis Group, LLC, an informa business,

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Preface

This book serves three different functions. It can be used as a dictionary of immunology or as a review guide for undergraduate, graduate, or medical students taking an immunology course. It can also provide a concise overview of basic immunology for readers who have not studied the subject previously but need immunology as a background for undergraduate or postgraduate work. The book also serves as a reference for those who already have a background in immunology but require a refresher on specific content.

Readers who already know some immunology and require a summary of particular aspects should consult the contents pages. The book is divided into five sections, each of which contains a number of related topics that are generally set out on double-page spreads. These topics are arranged in a logical sequence, so that sections 13 can be read as a short course of basic immunology, while section 4 provides the basis of clinical immunology and section 5 provides a review of immunological techniques.

To use the book as a dictionary, look up the word or abbreviation in the Index of Terms. This gives a single page number where a definition of the word will be found; associated terms will be found on the same page. Page references to particular topics set out over several pages are indicated in bold. Items found as entries in tables are given in italics.

This latest edition of the book has been comprehensively revised, to highlight the latest understanding of the subject, particularly in the areas of innate immune defenses and immunological techniques. Naturally a book of this kind cannot include everything of interest to immunologists. I have tried to cover all the essential areas of the subject, but I should be pleased to know when readers consider that particular subjects deserve further detail.

I am most grateful to colleagues who have allowed me to use micrographs and photographic illustrations; their contributions are individually acknowledged in the legends. For this edition, I am very pleased to be working with a new editorial team, including Denise Schanck, Monica Toledo, and Georgina Lucas from Garland Science, and with a new illustrator, Nigel Orme.

Contents

lymphocyte

basophil

plasma cell

megakaryocyte

antigenpresenting cell

mast cell

macrophage

platelets

erythrocyte

antigen

neutrophil

processed antigen

eosinophil

antibodies

MHC class I

MHC class II

CD8

CD4

T-cell receptor

Fc receptor

becomes

bacteria

virus

complement system molecules

LFA-I

ICAM-I