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Chrysalyne D. Schmults - High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management

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Chrysalyne D. Schmults High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management
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High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management: summary, description and annotation

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This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.

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Part I
Defining the Problem of High-Risk SCC
Springer-Verlag Berlin Heidelberg 2016
Chrysalyne D. Schmults (ed.) High-Risk Cutaneous Squamous Cell Carcinoma 10.1007/978-3-662-47081-7_1
1. Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma
Pritesh S. Karia 1
(1)
Department of Dermatology, Brigham and Womens Hospital, Boston, MA, USA
Pritesh S. Karia
Email:
Keywords
Non-melanoma skin cancer Cutaneous squamous cell carcinoma Risk factors Incidence Nodal metastasis Death from cutaneous squamous cell carcinoma
Introduction
Cutaneous squamous cell carcinoma (CSCC) is the second most common cancer diagnosed among whites in the United States []. Tumors with multiple high-risk factors (tumor diameter 2 cm, poorly differentiated histology, depth beyond fat, and perineural invasion 0.1 mm) have the greatest metastatic potential and result in the majority of SCC deaths.
The lifetime risk of developing SCC is 14 % in men and 9 % in women []. With the reported increase in SCC incidence, the incidence of poor outcomes resulting from SCC may be rising as well making SCC a potentially under recognized public health problem.
Incidence
The global age-adjusted incidence of SCC varies according to latitude. Studies have shown that SCC incidence doubles with each 8 to 10 decrease in latitude (proximity to the equator) [ summarizes the age-adjusted SCC incidence among white persons in various geographic areas of the world. There is nearly a 100-fold difference in SCC incidence between the white populations of Australia and northern European countries such as Finland and Denmark. These differences are partly attributed to differences in sun exposure.
Table 1.1
Population-based incidence of cutaneous squamous cell carcinoma by geographic location for white persons
Country
Region
Author (first and last)
Study period
Age adjusted SCC incidence (per 100,000)
Men
Women
Overall
Australia
Whole country
Staples, Giles et al. []
1985a
209.0
122.0
166.0
1990
338.0
164.0
250.0
1995
419.0
228.0
321.0
2002
499.0
291.0
387.0
Nambour, Queensland
Green, Weedon et al. []
19851992a
1035.0
472.0
Townsville, Queensland
Buettner and Raasch []
19961997a
1332.3
754.8
Canada
British Columbia
McLean, Lee et al. []
1973b
24.4
11.5
1983
35.6
16.9
1993
56.8
26.3
2003
60.3
32.4
Alberta
Jung, Salopek et al. []
1988b
45.0
22.9
33.0
1997
63.6
26.2
42.7
2006
60.2
30.5
43.4
Denmark
Whole country
Magnus []
19761985a
6.7
2.5
Finland
Whole country
Hannuksela-Svahn, Pukkala and Karvonen []
19561960a
3.2
1.8
19611965
4.2
2.2
19661970
3.9
2.3
19711975
4.1
2.3
19761980
4.6
2.5
19811985
5.2
3.3
19861990
6.2
3.9
19911995
7.2
4.2
Whole country
Magnus []
19761985a
5.6
3.9
Germany
Schleswig-Holstein
Katalinic, Kunze and Schafer []
19982001a
11.2
5.3
Iceland
Whole country
Magnus []
19761985a
7.1
4.0
Norway
Whole country
Iversen and Tretli []
19661970a
2.9
1.2
19711975
4.5
2.1
19761980
5.9
2.8
19811985
6.6
3.3
19861990
7.8
4.1
19911995
9.4
5.5
Whole country
Magnus []
19761985a
6.4
3.2
Sweden
North coast
Andersson and Wastensson []
1970b
6.8
6.4
North inland
1970
9.6
1.9
South coast
1970
11.3
4.7
South inland
1970
6.3
6.3
Gothenburg
1970
11.5
3.4
North coast
2007
82.2
40.8
North inland
2007
62.9
35.7
South coast
2007
95.8
68.4
South inland
2007
53.4
36.3
Gothenburg
2007
73.9
45.7
Whole country
Magnus []
19761985a
10.2
4.6
Switzerland
Vaud
Levi, Mezzanotte et al. []
19761985a
16.1
7.7
United Kingdom
West Glamorgan
Roberts []
1988a
31.7
6.2
19.0
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