Jocelyn E. Krebs - Lewin’s GENES XII

World Headquarters
Jones & Bartlett Learning
5 Wall Street
Burlington, MA 01803
978-443-5000
www.jblearning.com

Jones & Bartlett Learning books and products are available through most bookstores and online booksellers. To contact Jones & Bartlett Learning directly, call 800-832-0034, fax 978-443-8000, or visit our website, www.jblearning.com.

Substantial discounts on bulk quantities of Jones & Bartlett Learning publications are available to corporations, professional associations, and other qualified organizations. For details and specific discount information, contact the special sales department at Jones & Bartlett Learning via the above contact information or send an email to .

Copyright 2018 by Jones & Bartlett Learning, LLC, an Ascend Learning Company

All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the copyright owner.

The content, statements, views, and opinions herein are the sole expression of the respective authors and not that of Jones & Bartlett Learning, LLC. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not constitute or imply its endorsement or recommendation by Jones & Bartlett Learning, LLC and such reference shall not be used for advertising or product endorsement purposes. All trademarks displayed are the trademarks of the parties noted herein. Lewins Genes XII is an independent publication and has not been authorized, sponsored, or otherwise approved by the owners of the trademarks or service marks referenced in this product.

There may be images in this book that feature models; these models do not necessarily endorse, represent, or participate in the activities represented in the images. Any screenshots in this product are for educational and instructive purposes only. Any individuals and scenarios featured in the case studies throughout this product may be real or fictitious, but are used for instructional purposes only.

10464-6

Production Credits
VP, Executive Publisher: David D. Cella
Executive Editor: Matthew Kane
Associate Editor: Audrey Schwinn
Senior Developmental Editor: Nancy Hoffmann
Senior Production Editor: Nancy Hitchcock
Marketing Manager: Lindsay White
Production Services Manager: Colleen Lamy
Manufacturing and Inventory Control Supervisor: Amy Bacus
Composition: Cenveo Publisher Services
Cover Design: Kristin Parker
Rights & Media Specialist: Jamey OQuinn
Media Development Editor: Troy Liston
Cover Image: Laguna Design/Science Source
Printing and Binding: RR Donnelley
Cover Printing: RR Donnelley

Library of Congress Cataloging-in-Publication Data
Names: Krebs, Jocelyn E., author. | Goldstein, Elliott S., author. |
Kilpatrick, Stephen T., author.
Title: Lewins genes XII
Other titles: Genes XII | Lewins genes 12 | Lewins genes twelve
Description: Burlington, Massachusetts : Jones & Bartlett Learning, [2018] |
Includes index.
Identifiers: LCCN 2016056017 | ISBN 9781284104493
Subjects: | MESH: Genetic Phenomena
Classification: LCC QH430 | NLM QU 500 | DDC 576.5dc23
LC record available at https://lccn.loc.gov/2016056017

6048

Printed in the United States of America
21 20 19 18 17 10 9 8 7 6 5 4 3 2 1

Top texture: Laguna Design/Science Source

To Benjamin Lewin, for setting the bar high.

To my mother, Ellen Baker, for raising me with a love of science; to the memory of my stepfather, Barry Kiefer, for convincing me science would stay fun; to my wife, Susannah Morgan, for decades of love and support; and to my young sons, Rhys and Frey, clearly budding young scientists (I have a hypopesis). Finally, to the memory of my Ph.D. mentor Dr. Marietta Dunaway, a great inspiration who set my feet on the exciting path of chromatin biology.

Jocelyn Krebs

To my family: my wife, Suzanne, whose patience, understanding, and confidence in me are amazing; my children, Andy, Hyla, and Gary, who have taught me so much about using the computer; and my grandchildren, Seth and Elena, whose smiles and giggles inspire me. And to the memory of my mentor and dear friend, Lee A. Snyder, whose professionalism, guidance, and insight demonstrated the skills necessary to be a scientist and teacher. I have tried to live up to his expectations. This is for you, Doc.

Elliott Goldstein

To my family: my wife, Lori, who reminds me whats really important in life; my children, Jennifer, Andrew, and Sarah, who fill me with great pride and joy; and my parents, Sandra and David, who inspired the love of learning in me.

Stephen Kilpatrick

Top texture: Laguna Design/Science Source

Edited by Esther Siegfried

Edited by Hank W. Bass

Edited by Craig Peterson

Edited by Barbara Funnell

Edited by Hannah L. Klein and Samantha Hoot

Edited by Damon Lisch

Edited by Paolo Casali

Edited by Ellen Baker

Edited by Douglas J. Briant

Edited by Liskin Swint-Kruse

Edited by Trygve Tollefsbol

Edited by Trygve Tollefsbol

Top texture: Laguna Design/Science Source

Edited by Esther Siegfried

Edited by Hank W. Bass

Edited by Craig Peterson

Edited by Barbara Funnell

Edited by Hannah L. Klein and Samantha Hoot

Edited by Damon Lisch

Edited by Paolo Casali

Edited by Ellen Baker

Edited by Douglas J. Briant

Edited by Liskin Swint-Kruse

Edited by Trygve Tollefsbol

Edited by Trygve Tollefsbol

Top texture: Laguna Design/Science Source

Of the diverse ways to study the living world, molecular biology has been most remarkable in the speed and breadth of its expansion. New data are acquired daily, and new insights into well-studied processes come on a scale measured in weeks or months rather than years. Its difficult to believe that the first complete organismal genome sequence was obtained a little over 20 years ago. The structure and function of genes and genomes and their associated cellular processes are sometimes elegantly and deceptively simple but frequently amazingly complex, and no single book can do justice to the realities and diversities of natural genetic systems.

This book is aimed at advanced students in molecular genetics and molecular biology. In order to provide the most current understanding of the rapidly changing subjects in molecular biology, we have enlisted leading scientists to provide revisions and content updates in their individual fields of expertise. Their expert knowledge has been incorporated throughout the text. Much of the revision and reorganization of this edition follows that of the third edition of Lewins Essential GENES , but there are many updates and features that are new to this book. This edition follows a logical flow of topics; in particular, discussion of chromatin organization and nucleosome structure precedes the discussion of eukaryotic transcription, because chromosome organization is critical to all DNA transactions in the cell, and current research in the field of transcriptional regulation is heavily biased toward the study of the role of chromatin in this process. Many new figures are included in this book, some reflecting new developments in the field, particularly in the topics of chromatin structure and function, epigenetics, and regulation by noncoding RNA and microRNAs in eukaryotes.