Kewal K. Jain - Drug Delivery Systems

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For over 35 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice. These hallmark features were introduced by series editor Dr. John Walker and constitute the key ingredient in each and every volume of the Methods in Molecular Biology series. Tested and trusted, comprehensive and reliable, all protocols from the series are indexed in PubMed.

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The third edition of the Drug Delivery Systems in the Methods in Molecular Biology series continues the tradition of the previous two editions in presenting novel methods of drug delivery , some of which are described here for the first time. Most of the methods are used in the laboratories, but the chapter on the use of intrathecal delivery of analgesics in humans has been updated and a chapter on microanatomy relevant to this method of delivery has been added. Microbubble drug delivery for pancreatic cancer is a method that has transitioned from the laboratory to human clinical trials . The selection of topics reflects the current trends in drug delivery with predominant use of nanobiotechnology , which is the topic in 8 of the 16 chapters including a review chapter. Cancer is the most common condition for which drug delivery methods, particularly those applicable to targeted delivery , are being investigated. The introductory chapter of overview of drug delivery methods has been updated from previous editions. I hope that this book will continue to be useful for scientists in the industry and academia as well as physicians involved in research and clinical care of patients. Finally, I would like to acknowledge the valuable help of series editor, Prof. John Walker, in review and evaluation of half of the chapters, particularly those devoted to laboratory methods. Editors at Springer, David Casey and Anna Rakovsky, have been very helpful throughout the publication process of this book.