Heather A. E. Benson - Fundamentals of Drug Delivery

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 4
5. Chapter 5
6. Chapter 6
7. Chapter 7
8. Chapter 8
9. Chapter 9
10. Chapter 10
11. Chapter 12
12. Chapter 13
13. Chapter 15
14. Chapter 16
15. Chapter 18

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 4
5. Chapter 5
6. Chapter 6
7. Chapter 7
8. Chapter 8
9. Chapter 9
10. Chapter 10
11. Chapter 11
12. Chapter 12
13. Chapter 13
14. Chapter 14
15. Chapter 15
16. Chapter 16
17. Chapter 17
18. Chapter 19
19. Chapter 20

Edited by

Heather A. E. Benson
Curtin University of Technology, School of Pharmacy, Perth, Australia

Michael S. Roberts
University of Queensland, School of Medicine, Brisbane, Australia

Adrian C. Williams
University of Reading, School of Chemistry, Food and Pharmacy, Reading, UK

Xiaowen Liang
University of Queensland, Faculty of Medicine, Brisbane St Lucia, Australia

This edition first published 2022
2022 by John Wiley & Sons, Inc.

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The right of Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams, and Xiaowen Liang to be identified as the editors of this work has been asserted in accordance with law.

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Library of Congress CataloginginPublication Data

Names: Benson, Heather A. E., editor. | Roberts, Michael S., 1949 editor.
| Williams, Adrian C., 1963 editor. | Liang, Xiaowen, editor.
Title: Fundamentals of drug delivery / edited by Heather A. E. Benson,
Michael S. Roberts, Adrian C. Williams, Xiaowen Liang.
Description: Hoboken, NJ : Wiley, 2022. | Includes bibliographical
references and index.
Identifiers: LCCN 2021033395 (print) | LCCN 2021033396 (ebook) | ISBN
9781119769606 (cloth) | ISBN 9781119769651 (adobe pdf) | ISBN
9781119769675 (epub)
Subjects: MESH: Drug Delivery Systems | Drug Administration Routes
Classification: LCC RS199.5 (print) | LCC RS199.5 (ebook) | NLM QV 785 |
DDC 615/.6dc23
LC record available at https://lccn.loc.gov/2021033395
LC ebook record available at https://lccn.loc.gov/2021033396

Cover Design: Wiley
Cover Image: shutterstock\Yurchanka Siarhei

Effective, controlled drug delivery has the potential to greatly impact the therapeutic outcome, clinical benefit, and safety of drugs in a wide range of diseases and health conditions. There are a large number of potentially useful drugs with limited effectiveness and/or safety concerns due to poor drug delivery. This may occur because a physiologically relevant concentration is not delivered to the target site, does not remain in contact for a sufficient period, or causes adverse effects because of the resulting high blood concentrations associated with indiscriminate release. Controlled drug delivery systems are designed to carry the drug and release it at the target site in a timely manner, facilitating its absorption and optimizing its physiological action. An effective controlled drug delivery system improves efficacy and safety by controlling the rate, time, and place of drug release within the body, thereby minimizing dose requirements and the potential to interact with nontarget body sights that can contribute to undesirable side effects. Drug delivery has evolved from relatively simple systems to modern technologies designed to personalize medicines that have biologically precise drug release in response to realtime monitoring of body parameters.

Controlled drug delivery system development is rapidly evolving with an everincreasing focus on advanced technologies that bring together a wide range of skilled professions including pharmaceutical scientists, chemical, mechanical, and electrical engineers, chemists, physicists, and clinicians. It is an exciting field that has helped to advance clinical outcomes in almost every health condition, ranging from negating the need for coldchain storage thus allowing medicines to be transported to the most remote parts of the world, to precision targeting of drugs in cancer treatment. This book is designed to provide an insight into the fundamentals of drug delivery and the important processes in the development of controlled drug delivery systems.

The book is divided into three parts.

) introduces the concept of drug delivery and provides a perspective into the challenges, opportunities, and fundamental processes involved in the development of controlled drug delivery systems. It includes a historical perspective and a peek into the future of drug delivery. There is a focus on the drug development process, including the selection of pharmaceutical candidates and evaluation of their physicochemical characteristics with emphasis on the relevance to dosage form design. The role and application of mathematical modeling and the influence of drug transporters in pharmacokinetics and drug disposition complete this section.