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Goldblum John R. - Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract, and pancreas

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    Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract, and pancreas
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Gastrointestinal Tract Endoscopic and Tissue Processing Techniques and Normal Histology -- Screening and Surveillance Guidelines in Gastroenterology -- Diagnostic Cytology of the Gastrointestinal Tract -- Infectious Disorders of the Gastrointestinal Tract -- Manifestations of Immunodeficiency in the Gastrointestinal Tract -- Systemic Illnesses Involving the Gastrointestinal Tract -- Neuromuscular Disorders of the Gastrointestinal Tract -- Congenital and Developmental Disorders of the Gastrointestinal Tract -- Enteropathies Associated with Chronic Diarrhea and Malabsorption in Childhood -- Vascular Disorders of the Gastrointestinal Tract -- Autoimmune Disorders of the Gastrointestinal Tract -- Drug-Induced Disorders of the Gastrointestinal Tract -- Algorithmic Approach to Diagnosis of Inflammatory Disorders of the Gastrointestinal Tract -- Inflammatory Disorders of the Esophagus -- Inflammatory Disorders of the Stomach -- Inflammatory Disorders of the Small Intestine -- Inflammatory Disorders of the Large Intestine -- Inflammatory Disorders of the Appendix -- Polyps of the Esophagus -- Polyps of the Stomach -- Polyps of the Small Intestine -- Polyps of the Large Intestine -- Molecular Diagnostics of Tubal Gut Neoplasms -- Epithelial Neoplasms of the Esophagus -- Epithelial Neoplasms of the Stomach -- Epithelial Neoplasms of the Small Intestine -- Epithelial Neoplasms of the Large Intestine -- Epithelial Neoplasms of the Appendix -- Neuroendocrine Tumors of the Gastrointestinal and Pancreatobiliary Tracts -- Mesenchymal Tumors of the Gastrointestinal Tract -- Hematolymphoid Tumors of the Gastrointestinal Tract, Hepatobiliary Tract, and Pancreas -- Inflammatory and Neoplastic Disorders of the Anal Canal -- Gallbladder, Extrahepatic Biliary Tract, and Pancreas Tissue Processing Techniques and Normal Histology -- Molecular Genetics of Pancreatobiliary Neoplasms -- Diagnostic Cytology of the Biliary Tract and Pancreas -- Developmental Disorders of the Gallbladder, Extrahepatic Biliary Tract, and Pancreas -- Infectious and Inflammatory Disorders of the Gallbladder and Extrahepatic Biliary Tract -- Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract -- Inflammatory and Other Nonneoplastic Disorders of the Pancreas -- Tumors of the Pancreas -- Tumors of Major and Minor Ampulla -- Algorithmic Approach to Diagnosis of Liver Disorders -- Liver Tissue Processing and Normal Histology -- Molecular Pathogenesis and Diagnostics of Hepatocellular Tumors -- Diagnostic Cytology of the Liver -- Acute and Chronic Infectious Hepatitis -- Autoimmune and Chronic Cholestatic Disorders of the Liver -- Toxin- and Drug-Induced Disorders of the Liver -- Fatty Liver Disease -- Cirrhosis -- Vascular Disorders of the Liver -- Pathology of Liver and Hematopoietic Stem Cell Transplantation -- Liver Pathology in Pregnancy -- Inherited Metabolic and Developmental Disorders of the Pediatric and Adult Liver -- Benign and Malignant Tumors of the Liver.;The updated edition of Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas is designed to act as a one-stop medical reference book for the entire gastrointestinal system, providing exhaustive coverage and equipping you with all of the necessary tools to make a comprehensive diagnostic workup. Youll access thousands of high-quality illustrations and eight brand-new chapters, so you can recognize and diagnose any pathological slide you encounter. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make a comprehe.

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Goldblum John R.
Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract, and pancreas

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Table of Contents
List of tables
  1. Tables in Chapter 1
  2. Tables in Chapter 2
  3. Tables in Chapter 4
  4. Tables in Chapter 5
  5. Tables in Chapter 6
  6. Tables in Chapter 7
  7. Tables in Chapter 8
  8. Tables in Chapter 9
  9. Tables in Chapter 10
  10. Tables in Chapter 12
  11. Tables in Chapter 13
  12. Tables in Chapter 14
  13. Tables in Chapter 15
  14. Tables in Chapter 16
  15. Tables in Chapter 17
  16. Tables in Chapter 18
  17. Tables in Chapter 19
  18. Tables in Chapter 20
  19. Tables in Chapter 21
  20. Tables in Chapter 22
  21. Tables in Chapter 23
  22. Tables in Chapter 24
  23. Tables in Chapter 25
  24. Tables in Chapter 26
  25. Tables in Chapter 27
  26. Tables in Chapter 28
  27. Tables in Chapter 29
  28. Tables in Chapter 30
  29. Tables in Chapter 31
  30. Tables in Chapter 32
  31. Tables in Chapter 34
  32. Tables in Chapter 35
  33. Tables in Chapter 36
  34. Tables in Chapter 37
  35. Tables in Chapter 38
  36. Tables in Chapter 39
  37. Tables in Chapter 40
  38. Tables in Chapter 41
  39. Tables in Chapter 42
  40. Tables in Chapter 43
  41. Tables in Chapter 44
  42. Tables in Chapter 46
  43. Tables in Chapter 47
  44. Tables in Chapter 48
  45. Tables in Chapter 49
  46. Tables in Chapter 51
  47. Tables in Chapter 52
  48. Tables in Chapter 53
  49. Tables in Chapter 54
  50. Tables in Chapter 55
List of figures
  1. Figures in Chapter 1
  2. Figures in Chapter 2
  3. Figures in Chapter 3
  4. Figures in Chapter 4
  5. Figures in Chapter 5
  6. Figures in Chapter 6
  7. Figures in Chapter 7
  8. Figures in Chapter 8
  9. Figures in Chapter 9
  10. Figures in Chapter 10
  11. Figures in Chapter 11
  12. Figures in Chapter 12
  13. Figures in Chapter 13
  14. Figures in Chapter 14
  15. Figures in Chapter 15
  16. Figures in Chapter 16
  17. Figures in Chapter 17
  18. Figures in Chapter 18
  19. Figures in Chapter 19
  20. Figures in Chapter 20
  21. Figures in Chapter 21
  22. Figures in Chapter 22
  23. Figures in Chapter 23
  24. Figures in Chapter 24
  25. Figures in Chapter 25
  26. Figures in Chapter 26
  27. Figures in Chapter 27
  28. Figures in Chapter 28
  29. Figures in Chapter 29
  30. Figures in Chapter 30
  31. Figures in Chapter 31
  32. Figures in Chapter 32
  33. Figures in Chapter 33
  34. Figures in Chapter 34
  35. Figures in Chapter 35
  36. Figures in Chapter 36
  37. Figures in Chapter 37
  38. Figures in Chapter 38
  39. Figures in Chapter 39
  40. Figures in Chapter 40
  41. Figures in Chapter 41
  42. Figures in Chapter 42
  43. Figures in Chapter 43
  44. Figures in Chapter 44
  45. Figures in Chapter 45
  46. Figures in Chapter 46
  47. Figures in Chapter 47
  48. Figures in Chapter 48
  49. Figures in Chapter 49
  50. Figures in Chapter 50
  51. Figures in Chapter 51
  52. Figures in Chapter 52
  53. Figures in Chapter 53
  54. Figures in Chapter 54
  55. Figures in Chapter 55
Landmarks
Acknowledgments

As in previous editions, many individuals, both medical and nonmedical, contributed to the production of this textbook. We are most appreciative of all the technical, administrative, and support staff involved, but particularly Kendra Glueck-Abramson and Kathleen Ranney of the Brigham and Women's Hospital and Cleveland Clinic, respectively. We would like to thank our fellows Cheryl Adackapara and Kyle Viani of the Brigham and Women's Hospital and Drs. Homer Wiland, Kathryn Brown, and Lili Lee of the Cleveland Clinic for their diligent proofreading of the chapters. We would also like to thank Jonathan Alpert for his advice regarding the style of the book cover.

Professionally, I will always be greatly indebted to my longtime friends and mentors, Dr. Donald Antonioli and Dr. Harvey Goldman, for their lifelong support, teaching, and guidance both in my personal life and particularly in gastrointestinal pathology. Dr. Goldblum would like to acknowledge his lifelong mentor in gastrointestinal pathology, Dr. Henry Appelman. We would also like to thank Dr. James Crawford for his efforts in writing and editing several of the chapters related to liver pathology. Finally, we would like to thank all of the authors of the third edition for providing state-of-the-art, comprehensive discussions related to their fields of interest, and for their patience required to labor through the long and sometimes cumbersome editorial process.

Robert D. Odze MD, FRCP(C)

John R. Goldblum MD

Chapter 1
Gastrointestinal Tract Endoscopic and Tissue Processing Techniques and Normal Histology

Douglas G. Adler

Francis A. Farraye

James M. Crawford

Chapter Outline

Introduction

Endoscopy provides a unique opportunity to visualize the mucosal surface of the gastrointestinal (GI) tract as well as a variety of extraluminal and extraintestinal organs and structures. When considered within the context of a specific clinical picture, endoscopic images may be all that is needed to establish a specific diagnosis or provide sound clinical management. However, endoscopists often need to sample tissue. Examination by a qualified pathologist of specimens obtained at endoscopy is a routine and critical part of managing disorders of the alimentary tract. The purpose of this chapter is to orient the pathologist to the clinical and technical considerations unique to specimens obtained endoscopically from the alimentary tract. This is followed by a discussion of the normal anatomy of the tubal gut.

Bowel Preparation

The effectiveness of endoscopy often depends on the quality of the bowel preparation.

Table 1.1

Common Preparation Methods for Colonoscopy

48-hr clear liquid diet, 240-mL magnesium citrate PO, senna derivative laxative

48-hr clear liquid diet, senna derivative laxative, rectal enema

24-hr clear liquid diet, 240 mL magnesium citrate PO, or 4 L PEG-electrolyte lavage

24-hr clear liquid diet, 2 L PEG-electrolyte lavage, cascara-based laxative

24-hr clear liquid diet, 2 L sodium phosphate electrolyte lavage

PEG Polyethylene glycol PO per os by mouth Purgative- and - photo 1

PEG , Polyethylene glycol; PO , per os (by mouth).

Purgative- and laxative-based regimens are more likely to cause flattening of surface epithelial cells, goblet cell depletion, lamina propria edema, mucosal inflammation, and increased crypt cell proliferation, although these effects occur infrequently. Osmotic electrolyte solutions, such as PEG-based solutions, are better agents for preserving mucosal histology.

Methods for Obtaining Tissue Specimens

There are a limited number of methods available for obtaining tissue via GI endoscopy. This section describes several of these methods and the common situations in which they are used.

Endoscopic Pinch Biopsy

Pinch biopsy, performed with the use of a biopsy forceps during endoscopy, is the most common form of tissue sampling; the biopsy site is usually fully visualized at the time of sampling. Suction capsule biopsy requires fluoroscopic guidance to position a long tube with the biopsy apparatus and is done separately from endoscopy without visualization. Suction capsule biopsy without bowel visualization is still performed in some centers, but it is less successful than endoscopy-guided biopsy in obtaining tissue and therefore has fallen out of favor. Pinch biopsies may be small or large (the latter are referred to as jumbo biopsies) and can be obtained with or without the use of electrocautery. Electrocautery has value for hemostasis and destruction of residual tissue but introduces burn artifact into the harvested tissue.

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