David L Nelson - The Absolute, Ultimate Guide to Principles of Biochemistry [Study Guide and Solutions Manual]

Marcy Osgood

University of New Mexico School of Medicine

Karen Ocorr

Sanford Burnham Prebys Medical Discovery Institute

Solutions Manual based on
a previous edition by

Frederick Wedler
Robert Bernlohr
Ross Hardison
Teh-Hui Kao
Ming Tien

Pennsylvania State University

2017 by W. H. Freeman and Company

ISBN-13: 978-1-3191-2453-3

Printed in the United States of America

All rights reserved.

First printing

W. H. Freeman and Company
One New York Plaza
Suite 4500
New York, NY 10004-1562

www.macmillanlearning.com

Learning a complex subject, such as biochemistry, is very much like learning a foreign language.

In the study of a foreign language there are several distinct components that must be mastered: the vocabulary, the grammatical rules, and the integration of these words and rules so they can be used to communicate ideas. Similarly, in the study of biochemistry there is a very large (some would say vast) number of new terms and concepts, as well as a complex set of rules governing biochemical reactions that must all be memorized. All of this information must be integrated into an interrelated whole that describes biological systems.

Memorizing vocabulary and grammatical rules will not make you fluent in a foreign language; neither will such memorization make you fluent in biochemistry.

Similarly, listening to someone speak a foreign language will not, by itself, make you more capable of producing those same sounds, words, and sentences. The key to mastery of any new subject area, whether it is a foreign language or biochemistry, is the interaction of memorization, practice, and application until the information fits together into a coherent whole.

In this workbook we attempt to guide you through the material presented in Lehninger Principles of Biochemistry, Seventh Edition by Nelson and Cox. The Step-by-Step Guide to each chapter includes three parts:

• A one- to two-page summary of the Major Concepts helps you to see the big picture for each chapter.
• What to Review helps you make direct connections between the current material and related information presented elsewhere in the text.
• Topics for Discussion for each section and subsection in the chapter focus your attention on the main points being presented and help you internalize the information by using it.
• Discussion Questions for Study Groups are questions that are especially suited to Study Groups, either because they pull together several points made in the chapter or because they are more involved questions that would benefit from collaborative insight.

Each chapter also includes a Self-Test for you to assess your progress in mastering biochemical terminology and facts, and learning to integrate and apply that information.

• Do You Know the Terms? asks you to complete a crossword puzzle using the new vocabulary introduced in the chapter.
• Do You Know the Facts? tests how well you have learned the rules of biochemistry.
• Applying What You Know tests how well you speak the language of biochemistry, often in an experimental or metabolically relevant context.

Two especially popular features of the Absolute, Ultimate Guide are:

• The Biochemistry Online problems will expose you to just a few of the analytical resources that are available to scientists on the Internet. The molecular models are fun to play with, and many of the questions provide you with an opportunity to analyze data as you might in an actual laboratory setting.
• The Cell Map is based on many semesters of use by our students. It is designed to help you place the biochemical pathways that you are learning about into their proper cellular perspective. The Cell Map questions tell you what to include in your Map, but you can be creative!

Students have told us it is a great study aid, that really helped them to make the connections between the various pathways.

In our experience, this material can best be assimilated when it is discussed in a study group.

A study group is nothing more than two to four people who get together on a regular basis (weekly) to speak biochemistry. This type of interaction is critical to fluency in a foreign language and is no less critical in the successful assimilation of biochemistry. We designed our Step-by-Step Guide to each chapter with study groups in mind. The questions posed for each section can be used as springboards for study group discussions. We purposefully have not supplied answers to this section to force you to wrestle with the concepts. It is the struggle that will make you learn the material. In addition, because most of the answers can be readily worked out by a careful reading of the section of the text, the questions will focus your attention on the more important aspects of the material.

Detailed Solutions to all the end-of-chapter textbook problems are included as a separate section in the Absolute, Ultimate Guide.

We have taken great care to ensure that the solutions are correct, complete, and informative. The final answer to numerical problems has been rounded off to reflect the number of significant figures in the data.

We thank each and every one of our students for their invaluable feedback and input, which have helped to make this study guide its absolute and ultimate best.

Karen Ocorr received her Ph.D. from Wesleyan University, where she studied the physiology and neurochemistry of the lobster cardiac ganglion. As an NIH postdoctoral research fellow at the University of Texas, she examined the roles of enzymes and second messengers in neuronal plasticity in Aplysia californica. She continued these investigations at the California Institute of Technology and Stanford University, examining the role of intracellular signaling underlying long-term potentiation in the vertebrate hippocampus. She taught Introductory Biochemistry for 10 years at the University of Michigan, Ann Arbor, where she also taught Animal Physiology, Cell Biology, and Introductory Biology for Non-Majors. She also taught Introductory Biochemistry for four years as a visiting Professor at the Hunan Normal University in Changsha, China. Currently she is an Assistant Professor at SBP Medical Discovery Institute in La Jolla, California, where she is researching the roles of ion channels in cardiomyopathies. She currently teaches graduate and medical students at both the SBP Medical Discovery Institute and the University of CaliforniaSan Diego.