Rachel A. Powsner - Essentials of Nuclear Medicine Physics, Instrumentation, and Radiation Biology

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 8
5. Chapter 15
6. Chapter 16
7. Chapter 17
8. Chapter 19

1. Chapter 1
2. Chapter 2
3. Chapter 3
4. Chapter 4
5. Chapter 5
6. Chapter 6
7. Chapter 7
8. Chapter 8
9. Chapter 9
10. Chapter 10
11. Chapter 11
12. Chapter 12
13. Chapter 13
14. Chapter 14
15. Chapter 15
16. Chapter 16
17. Chapter 17
18. Chapter 18
19. Chapter 19

In memory of my parents, Rhoda and Edward Powsner, for all of their love, support, and guidance throughout the years.
R.A.P.

To the memory of my father, Ivan George Palmer, who would have said, Well, what's all this then?
M.R.P.

FOURTH EDITION

Rachel A. Powsner, MD

Clinical Professor of Radiology

Boston University School of Medicine

Director, Division of Nuclear Medicine

Department of Radiology

Boston Veterans Administration Healthcare System

Boston, MA, USA

Matthew R. Palmer, PhD

Director of Medical Imaging Physics

Department of Radiology

Beth Israel Deaconess Medical Center

Assistant Professor of Radiology

Harvard Medical School

Boston, MA, USA

Edward R. Powsner, MD*

Former Chief, Nuclear Medicine Service Veterans Administration Hospital

Allen Park, MI, USA

Former Professor and Associate Chairman

Department of Pathology

Michigan State University

East Lansing, MI, USA

*Deceased

This edition first published 2022
2022 John Wiley & Sons Ltd

Edition History
John Wiley & Sons, Ltd (3e, 2013)

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The right of Rachel A. Powsner and Matthew R. Palmer to be identified as the authors of this work has been asserted in accordance with law.

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The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress CataloginginPublication Data

Names: Powsner, Rachel A. author. | Palmer, Matthew R., 1958 author. | Powsner, Edward R., 1926 author.
Title: Essentials of nuclear medicine physics, instrumentation, and radiation biology / Rachel A. Powsner, Matthew R. Palmer, Edward R. Powsner.
Other titles: Essentials of nuclear medicine physics
Description: Fourth edition. | Hoboken, NJ : WileyBlackwell, 2022. | Preceded by: Essentials of nuclear medicine physics and instrumentation / Rachel A. Powsner, Matthew R. Palmer, Edward R. Powsner. Third edition. Chichester, West Sussex, UK : WileyBlackwell, 2013. | Includes bibliographical references and index.
Identifiers: LCCN 2021032438 (print) | LCCN 2021032439 (ebook) | ISBN 9781119620990 (paperback) | ISBN 9781119621003 (adobe pdf) | ISBN 9781119621010 (epub)
Subjects: MESH: Nuclear Medicine | Nuclear Medicineinstrumentation | Nuclear Physics | Radiation, Ionizing | Radiation Effects | Radioactive Hazard Releaseprevention & control
Classification: LCC R896.7 (print) | LCC R896.7 (ebook) | NLM WN 440 | DDC 616.07/575dc23
LC record available at https://lccn.loc.gov/2021032438
LC ebook record available at https://lccn.loc.gov/2021032439

Cover Design: Wiley
Cover Image: Courtesy of Rachel A. Powsner

After many years of postgraduate training, many physicians have forgotten some (or most) of their undergraduate and high school physics and may find submersion into nuclear physics somewhat daunting. This book begins with a very basic introduction to nuclear physics and the interactions of radiation and matter. It then proceeds with a discussion of the methods for production of nuclides and the instrumentation used for dose measurement, surveying radioactivity, and imaging. The imaging section has been expanded to cover MRI and PETMRI in addition to SPECT, PET, and PETCT. The final chapters of the book focus on radiation biology, radiation safety, radiopharmaceutical therapy, and radiation accidents.

Numerous illustrations are included. They are highly schematic and are designed to illustrate concepts rather than represent scale models of their subjects. This text is intended for radiology residents, cardiology fellows, nuclear medicine residents and fellows, nuclear medicine technology students, and others interested in an introduction to concepts in nuclear medicine physics and instrumentation.