Roy Aaron M.D. (editor) - Orthopaedic Basic Science: Fifth Edition: Print + Ebook: Foundations of Clinical Practice 5 (AAOS - American Academy of Orthopaedic Surgeons)

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Table of Contents

Acknowledgments

Editorial Board Orthopaedic Basic Science 5

Editors

Roy K. Aaron, MD

Professor, Orthopedic Surgery

Professor, Molecular Pharmacology, Physiology, and Biotechnology

Warren Alpert Medical School of Brown University

Providence, Rhode Island

Section Reviewers

Kevin C. Baker, PhD (Basic Disciplines in Orthopaedic Surgery)

Director, Orthopaedic Research

Department of Orthopaedic Surgery

Beaumont Health

Royal Oak, Michigan

Joshua J. Jacobs, MD (Basic Disciplines in Orthopaedic Surgery)

William A. Hark, MD/Susanne G. Swift Professor and Chairman, Department of Orthopaedic Surgery

Vice Provost for Research

Rush University

Chicago, Illinois

Linda J. Sandell, PhD, C-IAYT (Structure and Function of Musculoskeletal Tissues)

Editor in Chief, Journal of Orthopaedic Research

Professor Emerita, Department of Orthopaedic Surgery

Washington University

St. Louis, Missouri

Robert H. Brophy, MD (Pathophysiology and Orthopaedic Medicine)

Professor

Department of Orthopaedic Surgery

Washington University School of Medicine

St. Louis, Missouri

Robert L. Sah, MD, ScD (Repair and Regeneration)

Professor

Department of Bioengineering

University of California, San Diego

La Jolla, California

Barbara D. Boyan, PhD (Repair and Regeneration)

Professor, Department of Biomedical Engineering

Alice T. and William H. Goodwin, Jr. Dean

College of Engineering

Virginia Commonwealth University

Richmond, Virginia

Kurt P. Spindler, MD (Principles of Clinical Information)

Vice-Chair of Research Orthopaedic and Rheumatology Professor, Orthopaedic Surgery

Cleveland Clinic

Cleveland, Ohio

Patricia D. Franklin, MD, MBA, MPH (Principles of Clinical Information)

Professor and Co-Director, Outcomes and Measurement Hub

Department of Medical Social Sciences

Northwestern University Feinberg School of Medicine

Chicago, Illinois

We want to thank Ms. Jennifer Racine-Avila for her editorial and graphics guidance and digital support. Her contributions to this edition were invaluable.

Index

Note: Page numbers followed by f indicate figures and t indicate tables.

A

Achondroplasia,

ACL injuries. SeeAnterior cruciate ligament (ACL) injuries

ACLR. SeeAnterior cruciate ligament reconstruction (ACLR)

Acute disseminated encephalomyelitis (ADEM),

Acute flaccid myelitis (AFM),

Adolescent idiopathic scoliosis,

Advanced glycation end-products (AGEs),

Advance Notice of Proposed Rulemaking (ANPRM),

Adverse bone remodeling,

AFFs. SeeAtypical femur fractures (AFFs)

Aging-induced atrophy,

Alcohol,

ALS. SeeAmyotrophic lateral sclerosis (ALS)

Aluminum-associated osteomalacia,

American Academy of Orthopaedic Surgeons (AAOS),

American Association of Orthopaedic Surgeons,

American College of Surgeons (ACS),

American Medical Association (AMA),

Amino acid sequence,

Amphiarthroses,

Amyotrophic lateral sclerosis (ALS)

clinical presentation,

diagnosis,

incidence of,

management,

pathogenesis,

Ankylosing spondylitis (AS),

Anterior cord syndrome,

Anterior cruciate ligament (ACL) injuries,

sexual dimorphism,

Anterior cruciate ligament reconstruction (ACLR),

bone-to-bone healing,

incidence of,

mechanical factors,

tendon-bone tunnel healing,

Antibiotic-impregnated cement spacers,

Anti-inflammatory cytokines,

Antimicrobials,

antibiotic-impregnated cement spacer,

bioavailability,

elution of,

Apical ectodermal ridge (AER),

Articular cartilage. See alsoCartilage homeostasis; Extracellular matrix (ECM)

biologic response,

biomechanics

chondrocytes,

collagen fibrils,

composition,

degeneration,

delamination damage,

diarthrodial joints,

enzymatic degradation,

feedback system,

friction,

implications,

interstitial fluid pressurization, 159

joint degeneration,

joint loading-induced deformation,

mechanotransduction,

permeability,

primary function,

proteoglycans,

static compressive loads,

stresses and strains,

tissue function,

ultrastructure,

wear,

chondrocytes,

chondrogenesis,

development,

diarthrodial joints,

elastic cartilage,

extracellular matrix,

fibrocartilage,

hyaline cartilage,

osteoarthritis (OA),

repair

acellular scaffold-based therapies,

assessment,

augmentation,

autologous cell populations,

autologous chondrocyte implantation (ACI),

biochemical signaling,

bone marrow stimulation,

cell-based therapies,

focal defects,

goal of,

interventions,

joint distraction,

joint replacement,

mesenchymal stem cells (MSCs),

minced and particulate cartilage,

nonsurgical interventions,

organ system,

osteoarthritis (OA),

osteochondral grafting,

osteochondral implants,

osteochondral unit,

osteotomy,

platelet-rich plasma (PRP),

regenerative techniques,

scaffolds,

strategies,

synovial joints,

tissue components,

tissue substitution,

zonal organization

cartilage-bone interface,

chondroitin sulfate-modified proteoglycans,

macromolecules,

medial femoral condyle,

Aseptic loosening,

Aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL),

Association of Research Circulation Osseous (ARCO) system,

Atypical femur fractures (AFFs),

Augmentation, articular cartilage repair,

Autograft and allograft implants,

Autoimmune diseases (ADs),

Autologous chondrocyte implantation (ACI),

B

Ball-and-socket joint,

Ballistic injuries,

Basic calcium phosphate (BCP) crystals,

Bayesian statistical inference,

Beavis effect,

Becker muscular dystrophy (BMD),

Belmont Report,

Best-practice guidelines,

bias in,

development,

ethical and legal implications,

Institute of Medicine,

Big Data Knowledge Portals,

Bioabsorbable bone fixation devices,

Bioactive ceramics,

Biochemical coupling,

Biocompatibility,

functional integration,

orthopaedic implants,

toxic effects,

Bioinformatics resources,

Biologics License Application (BLA),

Biomaterials. See alsoOrthopaedic biomaterials

biocompatibility

functional integration,

orthopaedic implants,

toxic effects,

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