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Carolina Witchmichen Penteado Schmidt - Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists: The Gold Standard to Practice

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Carolina Witchmichen Penteado Schmidt Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists: The Gold Standard to Practice

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Carolina Witchmichen Penteado Schmidt Pediatric Hematopoietic Stem Cell - photo 1
Carolina Witchmichen Penteado Schmidt
Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists
The Gold Standard to Practice
Carolina Witchmichen Penteado Schmidt Curitiba Paran Brazil ISBN - photo 2
Carolina Witchmichen Penteado Schmidt
Curitiba, Paran, Brazil
ISBN 978-3-030-43490-8 e-ISBN 978-3-030-43491-5
https://doi.org/10.1007/978-3-030-43491-5
Springer Nature Switzerland AG 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

The outcome for children with cancer has shown enormous improvement over the last decades. In economically privileged countries, overall survival rates have now reached 80% at 5 years from diagnosis, and most of these young people will become long-term survivors.

Therefore, an optimal management of children with cancer is needed, based on knowledge of current treatment strategies. Treatment options in pediatric oncology are chemotherapy, radiotherapy, and surgery. However, some patients also require a stem cell transplantation to have a chance for cure.

Treatment of childhood cancer patients affects not only medical doctors or nurses but also pharmacists. Thus more and more knowledge about pediatric oncology pharmacy is required in daily practice. But up to now there is no book available for pharmacists who are involved in the field of pediatric stem cell transplantation to find the information they are looking for.

With this book Carolina Schmidt has closed that previous gap. After publishing several books about pediatric oncologic pharmacy like Drug Therapy and Interactions in Pediatric Oncology: A Pocket Guide, Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old, and Pediatric Oncologic Pharmacy: A Complete Guide to Practice, Carolina Schmidt addresses in this book a wide range of topics, for example, the background of hematopoietic stem cell transplantation, its meaning in the various kinds of childhood cancer, graft-versus-host disease, and antibacterial, antifungal, and antiviral prophylaxis.

All in all Carolina Schmidt has written an important book in a clear and professional style again. For the first time there is a book intended for all pharmacists who deal with the topic of stem cell transplantation for children and who want to find all needed information in one place. So I hope that the book will be widely distributed. I thank Carolina Schmidt for her innovative book idea and for the result of her work.

Christian Mller
Acknowledgments

This book was possible due to the support of a lot of people. I would like to thank Vanessa Shimabukuro, my dedicated Springer editor, Anila Vijayan and her team, and the Springer team, for dedicating their time to transform a manuscript into a beautiful and easy-to-read book; the professionals and institutions who bought this book, which was written with a lot of work and dedication, with them in mind, to help in this journey to cure children; Frederico Schmidt, my husband, for his constant support; and my family, for supporting my work and Christian Mller, for the foreword.

Contents
About the Author
Carolina Witchmichen Penteado Schmidt

Pediatric Oncologic Pharmacist and Writer. MBA in Planning and Business Management and Oncological Hospital Pharmacy Specialist. She is author of Chubbys Tale: The True Story of a Teddy Bear Who Beat Cancer (in the BookAuthority list of 81 Best Leukemia Books of All Time) and of the Springer books Pediatric Oncologic Pharmacy: A Complete Guide to Practice (in the BookAuthority lists: Best Pharmacy Books of All Time, Best Pharmacy Books to Read in 2020, and Best Pharmacy ebooks of All Time), Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old, and Drug Therapy and Interactions in Pediatric Oncology: A Pocket Guide. She has extensive experience with chemotherapy in children, as well as in hospitals and clinics with pharmacy, drug interactions, pediatrics, oncology, hematology, neonatology, intensive healthcare, and infectology. She has academic experience in pharmacy, pediatrics, oncology, and hematology, teaching specialists such as pharmacists, physicians, and nurses. She always had a fascination for hematopoietic stem cell transplantation in pediatrics, having worked with several pediatric stem cell transplantations and writing about this theme for children in her book Chubbys Tale: The True Story of a Teddy Bear Who Beat Cancer. She published several childrens booksunder the pen name Carola Schmidtabout cancer, such as Bald Is Beautiful: A Letter for a Fabulous Girl.

Springer Nature Switzerland AG 2020
C. W. P. Schmidt Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists https://doi.org/10.1007/978-3-030-43491-5_1
1. The Pharmacist in Pediatric Hematopoietic Stem Cell Transplantation
Carolina Witchmichen Penteado Schmidt
(1)
Curitiba, Paran, Brazil
Carolina Witchmichen Penteado Schmidt

Hematopoietic stem cell transplantation (HSCT) has been used for a variety of malignant and nonmalignant diseases of the blood and immune-system in adults, children, and even infants. The HSCT involves the ablation of the bone marrow of the recipient with high doses of chemotherapy, and in some cases also radiation , to allow engraftment of the donor cells. It is autologous when the cells are from the own patient and allogeneic when the cells comes from a donor. The ability to successfully transplant hematopoietic stem cells to reconstitute the hematopoietic system is a relatively new area and in constant development [].

Multidrug therapy is required in HSCT area. High-doses of chemotherapy are used to kill tumorous cells at the cost of profound myelosuppression . Multidrug therapy is used to overcome resistance and heterogeneity of malignant cells. Moreover, there are many supportive drugs used to prevent and treat a variety of infections and rejection . Therefore, in this area, not only pediatric oncologic pharmacists but also clinical pharmacists are necessary [].

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