Angelo Michele Carella (editor) - Autologous stem cell transplantation : biological and clinical results in malignancies

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Copyright 1998 Taylor & Francis

Published by Routledge
2 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN
270 Madison Ave, New York NY 10016

Routledge is an imprint of the Taylor & Francis Group, an informa business

Transferred to Digital Printing 2007

All rights reserved.

No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying and recording, or by any information storage or retrieval system, without permission in writing from the publishers.

---

British Library Cataloguing in Publication Data

Autologous stem cell transplantation : biological and
clinical results in malignancies. (Advances in blood
disorders series)
1. Auto transplantation 2. Hematopoietic stem cells Transplantation 3. Blood Tumors Treatment
I. Carella, Angelo M.
616.9941806

ISBN 3-7186-5933-6

Publishers Note
The publisher has gone to great lengths to ensure the quality of this reprint but points out that some imperfections in the original may be apparent

CONTENTS

R.P. Gale, P.A. Rowlings and J. O. Armitage

T.E. Thomas and P.M. Lansdorp

M.A.S. Moore

A.S. Tsukamoto, D. van den Berg, C. Reading, J. Tong, L. Murray, A. Carella, F. Frassoni, D. Snyder, G. Herzig, C. Gorin, J. LaPorte, R. Negrin, K. Blume, I. Cunningham, D. Claxton, A. Deisseroth and R. Hoffman

R.J. Tushinski and R. Hoffman

H.M. Prince and A. Keating

A.B. Deisseroth, M. Talpaz, R. Berenson, S. Heimfeld, C. Reading, J. Hester, M. Korbling, J. Liang, D. Seong, R. Champlin, H. Kantarjian, I. Khouri and S. Giralt

R.Foa

R.B. Jones, P. Cagnoni, S.I. Bearman and E.J. Shpall

L. Foroni, L. Coyle, M.F. Cole Sinclair, J.C. Yaxley, J.S. Chim and A.V. Hoffbrand

U.M. Gehling, C.H. Hogan, A. Gee, P. Cagnoni, W. Franklin, R.B. Jones, S.I. Bearman, M. Ross and E.J. Shpall

S. Gulati, C. Romero, V. Rizzoli and C. Carlo-Stella

J.G. Gribben

G. Molineux and I.K. McNiece

R.J. Jones and A.D. Hess

F.R. Appelbaum

G.W. Santos

R.S. Negrin and K.G. Blume

F. Frassoni and N.C. Gorin

D. Hoelzer

E. Plouvier and P. Herve

J.M. Rowe, I.M. Franklin and H.M. Lazarus

T. Bchner and L. W. Hiddemann

A.K. Burnett

G. Saglio and F. Lo Coco

J.M. Goldman and S.G. OBrien

M.J. Barnett, H.G. Klingemann, C.J. Eaves and A.C. Eaves

A.M. Carella, F. Chimirri, F. Benvenuto, O. Figari, E. Lerma, A. Dejana, E. Prencipe, L. Celesti and M. Podest

A.K. Fielding and A.H. Goldstone

J. M. Vose, P.J. Bierman and J.O. Armitage

C. Gisselbrecht and B. Coiffier

J.W. Sweetenham

D. Frappaz, J.Y. Blay, E. Bouffet, M. Brunat-Mentigny and T. Philip

D.L. Longo

D.E. Reece

B. Barlogie, S. Jagannath, D.H. Vesole, N. Munshi, D. Siegel and G. Tricot

J.A. Ledermann and A.L. Jones

B.D. Cheson

O. Hartmann and D. Valteau-Couanet

Ph. Henon

E. Gluckman

S. Slavin, E. Naparstek, A. Nagler, A. Ackerstein, G. Varadi, J. Kapelushnik and R. Or

A.M. Marmont

Much has changed in the field of hematology, particularly during the past decade. New advances in therapy and great achievements in cytogenetics, molecular biology and chemotherapy, coupled with development of growth factors, have all radically changed the clinical and basic approach to the therapy of many blood disorders. In particular, our understanding of the basic concepts of neoplasia has altered quite radically during this period of time.

The chapters covered in this series reflect these changes and each will appear as a separate handbook in the series. I have also requested the authors to summarize major issues in hematology and to cover both clinical and laboratory aspects of these disorders. These will include the addition of all new data made available via the great advances in research of these topics, which have added so much to our understanding of these disorders.

I do hope that the reader will benefit from the entire series which should be suited for all specialists and postgraduate physicians in training as well as for undergraduate teaching in hematology.

Professor Aaron Polliack, M.D.
Hadassah-Hebrew University Medical Centres
Jerusalem, Israel

The present book aims to present the historical development of use of Autologous Stem Cell Transplantation (ASCT) in hematological and non hematological malignancies in such a way as to preserve a proper balance between what may be called clinical history and biological history that have determinated the cause of that development at different periods.

The editor is convinced that the basis for an understanding of present-day research on ASCT in hematological and non hematological malignancies and for an enlightened attitude towards questions affecting this scientific matter today is a knowledge of the path which it has pursued in becoming what it is. For this reason, many investigators worldwide have been requested to report their experience and achievements in this field.

It is a pleasure to acknowledge the many obligations incurred in the preparation of the book. To all scientists who have accepted to take part in this work; without their willingness and enthusiasm it wouldnt have been possible to collect all up-to-date reviews of the variety of therapeutic methods available today.

To Francesca Chimirri, Maria Angela Capurro, Paula Debbia for their assistance in typing and correction of the proofs.

I am indebted to Professor Alberto Marmont, not only for his introduction to the book but for his willingness at any time to share with me his scientific knowledge and judgment.

Finally, I should like to record the debt of gratitude which I owe to my wife for her cheerful assistance.

Angelo Michele Carella

This is, under all aspects, an important book. It comprises 43 chapters, all of them written by well-established and in most cases truly outstanding investigators, both biologists and clinicians. The customary question arises, whether it is timely, genuinely instructive for the average hematologist-oncologist, and worthy of being included in the Olympus of recommended reading. The answer is most emphatically affirmative, and Angelo Carella should be congratulated for the excellent selection of themes and authors.

It is quite impossible even to give an outline of the series of chapters composing this impressive volume. One general point I should like to make is that very rarely, outside of hematology, does one find a more intimate and rewarding relationship between basic biology and clinical interventions. To give an example, the very competent discussions of hematopoietic stem cells by Thomas/Lansdorp and by Malcolm Moore are quite fundamental to all clinical procedures that follow, whether utilizing marrow or peripheral stem cells; these last are discussed with his usual competence by Philippe Henon. Some contributions review simultaneously biological and clinical aspects, as in Eliane Gluckmanns state of the art discussion of cord stem cells. Will it be possible, in the near future, to concretely expand the few stem cells contained in a single, easy to perform myeloaspirate, up to the point of disposing of an adequate, promptly acting hematopoietic graft, as suggested by Tushinsky and Hoffman? Will it be possible to compensate/control the telomeric attrition which is being gradually identified as the main factor of stem cell aging?

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