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Bykerk Vivian P. - Preclinical Rheumatic Disease, An Issue of Rheumatic Disease Clinics, E-Book

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Approximately 580,000 adults in England currently have the disease with a further 26,000 new cases diagnosed each year. Rheumatoid arthritis costs the NHS an estimated 560 million annually and the estimated cost to the economy of sick leave and work-related disability for people with rheumatoid arthritis is 1.8 billion a year. The NHS does not consistently provide support for people with the disease to remain in, or get back into, work, with a lack of local links between the NHS and Jobcentre Plus services. Early diagnosis is the key to the successful treatment of rheumatoid arthritis but public awareness of the disease is low. People often delay seeking medical help from their GP, the disease is difficult to diagnose and requires specialist knowledge; and few GPs have the specialist expertise required to diagnose rheumatoid. The average length of time from symptom onset to treatment is nine months, compared to the clinically recommended period of three months, and this has not improved in the past five years. There is inconsistent coordination of the roles and activities of staff in different parts of the NHS: for example between GPs and hospital specialists. Furthermore, many patients do not have sufficient access to psychological services even though depression is common for people with rheumatoid arthritis; and the provision of quick response appointments in the event of a flare up is inconsistent. Current services also do not always match the Governments vision of a systematic patient-centred approach and the majority of PCTs are not commissioning as effectively as they could as they do not know the numbers of people in their area with rheumatoid arthritis.

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Table of Contents
List of tables
  1. Tables in Gout
  2. Tables in Preclinical Systemic Lupus Erythematosus
  3. Tables in Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases
  4. Tables in Detecting the Earliest Signs of Rheumatoid Arthritis
  5. Tables in Mucosal Immune Responses to Microbiota in the Development of Autoimmune Disease
  6. Tables in Challenges in Imaging in Preclinical Rheumatoid Arthritis
  7. Tables in Identification of Self-antigenspecific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis
  8. Tables in Prediction of Future Rheumatoid Arthritis
  9. Tables in Developing Evidence-Based Screening Recommendations, with Consideration for Rheumatology
  10. Tables in Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease
List of Figures
  1. Figures in Preclinical Inflammatory Rheumatic Diseases
  2. Figures in Gout
  3. Figures in Insights from Populations at Risk for the Future Development of Classified Rheumatoid Arthritis
  4. Figures in Preclinical Systemic Lupus Erythematosus
  5. Figures in Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases
  6. Figures in Is Preclinical Autoimmunity Benign?
  7. Figures in Recognition of Preclinical and Early Disease in Axial Spondyloarthritis
  8. Figures in Identifying and Treating Preclinical and Early Osteoarthritis
  9. Figures in Mucosal Immune Responses to Microbiota in the Development of Autoimmune Disease
  10. Figures in Challenges in Imaging in Preclinical Rheumatoid Arthritis
  11. Figures in Identification of Self-antigenspecific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis
  12. Figures in Prediction of Future Rheumatoid Arthritis
  13. Figures in Prevention of Rheumatic Diseases
  14. Figures in Developing Evidence-Based Screening Recommendations, with Consideration for Rheumatology
  15. Figures in Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease
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Clinics Review Articles RHEUMATIC DISEASE CLINICS OF NORTH AMERICA Preclinical - photo 1
Clinics Review Articles
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Preclinical Rheumatic Disease

Vivian P. Bykerk, MD

Weill Cornell Medical College, Inflammatory Arthritis Center, Hospital for Special Surgery, New York, NY, USA

Karen H. Costenbader, MD, MPH

Division of Rheumatology, Immunology, and Allergy, Brigham and Womens Hospital, Boston, MA, USA

Kevin Deane, MD, PhD

Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA

ISSN 0889-857X
Volume 40 Number 4 November 2014

Elsevier

Contributors
Consulting Editor

MICHAEL H. WEISMAN, MD

Director, Division of Rheumatology; Professor of Medicine, Cedars-Sinai Medical Center, Los Angeles, California

Editors

VIVIAN P. BYKERK, MD

Associate Professor of Medicine, Weill Cornell Medical College, Director of the Inflammatory Arthritis Center, Hospital for Special Surgery, New York, New York

KAREN H. COSTENBADER, MD, MPH

Associate Professor of Medicine, Harvard Medical School, Co-Director, Lupus Center, Division of Rheumatology, Immunology and Allergy, Brigham and Womens Hospital, Boston, Massachusetts

KEVIN DEANE, MD, PhD

Associate Professor of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado

Authors

HELEN BENHAM, B.App.Sci, MBBS (Hons), FRACP, PhD

Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Queensland, Australia; The University of Queensland School of Medicine, Brisbane, Queensland, Australia

VIVIAN P. BYKERK, MD, FRCPC

Associate Professor of Medicine, Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York

NED CALONGE, MD, MPH

President and CEO, The Colorado Trust; Associate Professor, Department of Family Medicine, University of Colorado School of Medicine; Associate Professor, Department of Epidemiology, Colorado School of Public Health, Denver, Colorado

ROWLAND W. CHANG, MD, MPH

Professor in Medicine, Division of Rheumatology; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

KAREN H. COSTENBADER, MD, MPH

Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts

KEVIN D. DEANE, MD, PhD

Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado

M. KRISTEN DEMORUELLE, MD

Assistant Professor of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado

DAVID T. FELSON, MD, MPH

Professor of Medicine and Epidemiology, Medicine, Boston University School of Medicine, Boston, Massachusetts; Professor of Medicine and Public Health, University of Manchester, Manchester, Lancashire, United Kingdom; Clinical Epidemiology Unit, Boston University, Boston, Massachusetts; NIHR Biomedical Research Unit, University of Manchester, Manchester, United Kingdom

AXEL FINCKH, MD

Division of Rheumatology, University Hospital of Geneva, Genve, Switzerland

DANIELLE M. GERLAG, MD, PhD

Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; GlaxoSmithKline, Cambridge, United Kingdom

RICHARD HODGSON, BM, PhD

NIHR Biomedical Research Unit, University of Manchester, Manchester, United Kingdom

V. MICHAEL HOLERS, MD

Professor of Medicine and Immunology, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado

ROBERT D. INMAN, MD

Professor of Medicine/Immunology, Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

JUDITH A. JAMES, MD, PhD

Lou Kerr Chair in Biomedical Research; Program Head, Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; Associate Vice Provost of Clinical and Translational Science and Professor, Departments of Medicine, Pathology, Microbiology and Immunology, Oklahoma Clinical and Translational Science Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

SEOYOUNG C. KIM, MD, ScD, MSCE

Divisions of Pharmacoepidemiology and Pharmacoeconomics and of Rheumatology, Allergy and Immunology, Brigham and Womens Hospital, Boston, Massachusetts

KRISTINE A. KUHN, MD, PhD

Assistant Professor of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado

TABITHA N. KUNG, MD, MPH, FRCPC

Clinical Associate, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

SOI-CHENG LAW, BSc (Hons)

Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Queensland, Australia

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