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Table of Contents
List of tables
  1. Tables in Incidence and Prevalence of Hyperhidrosis
  2. Tables in Impact of Hyperhidrosis on Quality of Life and its Assessment
  3. Tables in Botulinum Toxin for Axillary Hyperhidrosis
  4. Tables in Botulinum Neurotoxin Treatment of Palmar and Plantar Hyperhidrosis
  5. Tables in Botulinum Toxin for Hyperhidrosis of Areas Other than the Axillae and Palms/Soles
  6. Tables in Local Procedural Approaches for Axillary Hyperhidrosis
  7. Tables in Endoscopic Thoracic Sympathectomy
List of Figures
  1. Figures in Topical Therapies in Hyperhidrosis Care
  2. Figures in Iontophoresis for Palmar and Plantar Hyperhidrosis
  3. Figures in Botulinum Toxin for Axillary Hyperhidrosis
  4. Figures in Botulinum Neurotoxin Treatment of Palmar and Plantar Hyperhidrosis
  5. Figures in Botulinum Toxin for Hyperhidrosis of Areas Other than the Axillae and Palms/Soles
  6. Figures in Local Procedural Approaches for Axillary Hyperhidrosis
  7. Figures in Endoscopic Thoracic Sympathectomy
  8. Figures in Resources for Hyperhidrosis Sufferers, Patients, and Health Care Providers
  9. Figures in Incorporating Diagnosis and Treatment of Hyperhidrosis into Clinical Practice
Landmarks
Clinics Review Articles Dermatologic Clinics Hyperhidrosis David M Pariser - photo 1
Clinics Review Articles
Dermatologic Clinics
Hyperhidrosis

David M. Pariser, MD, FACP, FAAD

International Hyperhidrosis Society, Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USA

ISSN 0733-8635
Volume 32 Number 4 October 2014

Contributors
Consulting Editor

BRUCE H. THIERS, MD

Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina

Editor

DAVID M. PARISER, MD, FACP, FAAD

Secretary and Founding President, International Hyperhidrosis Society, Quakertown, Pennsylvania; Professor, Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia

Authors

ANGELA BALLARD, RN

International Hyperhidrosis Society, Quakertown, Pennsylvania

BENJAMIN R. BOHATY, MD

Fellow, Department of Dermatology, The University of Texas Health Science Center at Houston, Houston, Texas

TIMUR A. GALPERIN, DO

Clinical Research Fellow, Department of Dermatology, Saint Louis University School of Medicine, St Louis, Missouri

DEE ANNA GLASER, MD

Professor and Vice Chairman, Department of Dermatology, Saint Louis University School of Medicine, St Louis, Missouri

HENNING HAMM, MD

Professor of Dermatology, Department of Dermatology, Venereology and Allergology, University Hospital Wrzburg, Wrzburg, Germany

ADELAIDE A. HEBERT, MD

Professor, Departments of Dermatology and Pediatrics, The University of Texas Health Science Center at Houston, Houston, Texas

SAMANTHA HILL, MD, FAAD

RidgeView Dermatology, Lynchburg, Virginia

SUELEN MONTAGNER, MD

Dermatologist Physician, Campinas, So Paulo, Brazil

ELENI MORAITES, MD

Transitional Resident, Hennepin County Medical Center, Minneapolis, Minnesota

CHRISTIAN MURRAY, MD, FRCPC

Division of Dermatology, Womens College Hospital, University of Toronto, Toronto, Ontario, Canada

DAVID M. PARISER, MD, FACP, FAAD

Secretary and Founding Member, International Hyperhidrosis Society, Quakertown, Pennsylvania; Professor, Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia

LISA J. PIERETTI, MBA

Executive Director and Founding Member, International Hyperhidrosis Society, Quakertown, Pennsylvania

NOWELL SOLISH, MD, FRCPC

Division of Dermatology, Womens College Hospital, University of Toronto, Toronto, Ontario, Canada

ADA REGINA TRINDADE DE ALMEIDA, MD

Dermatologist Physician, Assistant Physician, Department of Dermatology, Hospital do Servidor Pblico Municipal de So Paulo (SP), So Paulo, So Paulo, Brazil

OLUSHOLA AKINSHEMOYIN VAUGHN, BA

Student, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin

TESSA WEINBERG

School of Medicine, Royal College of Surgeons of Ireland, Dublin 2, Ireland

Contents
Preface: Hyperhidrosis xi

David M. Pariser

Incidence and Prevalence of Hyperhidrosis 457

Eleni Moraites, Olushola Akinshemoyin Vaughn, and Samantha Hill

Hyperhidrosis is a skin disorder characterized by excessive sweating that often causes significant impairment in social, occupational, and emotional wellbeing. Hyperhidrosis is thought to affect 2.8% of the US population and can be of primary or secondary origin. Primary hyperhidrosis is usually bilateral, symmetric, and focal. The most common focal sites include, but are not limited to, the palms, soles, and axillae. Secondary hyperhidrosis is usually caused by an underlying medical condition or medication. Secondary hyperhidrosis must be ruled out before a diagnosis of primary hyperhidrosis is made.

Impact of Hyperhidrosis on Quality of Life and its Assessment 467

Henning Hamm

Hyperhidrosis is an embarrassing condition that may interfere with routine activities, cause emotional distress, and disturb both professional and social lives of patients. Objective examination is variable and unreliable, so efforts have been made in the last 15 years to substantiate the limitations of these patients, especially in primary focal hyperhidrosis. Almost all therapeutic studies use standardized or self-designed instruments to evaluate the impact of the disease on quality of life and the improvement achieved by treatment. This article gives an overview of the difficulties with which patients with hyperhidrosis are confronted and of research investigating the restrictions.

Special Considerations for Children with Hyperhidrosis 477

Benjamin R. Bohaty and Adelaide A. Hebert

Hyperhidrosis, characterized by excess sweat production, affects children and adults. Primary focal hyperhidrosis affects any anatomic region with sweat appendages present. Primary hyperhidrosis has traditionally been considered a problem for adults, but approximately 1.6% of adolescents and 0.6% of prepubertal children are affected. Psychological and social development and well-being are often affected, leading to profound emotional and social distress. Quality of life can be improved by early diagnosis and therapy; however, underdiagnosis and lack of knowledge regarding therapeutic options has hindered optimization of therapy in the pediatric population. This article reviews the treatment options for hyperhidrosis with a focus on the pediatric population.

Topical Therapies in Hyperhidrosis Care 485

David M. Pariser and Angela Ballard

Primary focal hyperhidrosis affects 3% of the US population; about the same number as psoriasis. More than half of these patients have primary focal axillary hyperhidrosis: sweating that is beyond what is anticipated or necessary for thermoregulation. Most topical therapies are based on aluminum salts, which work by a chemical reaction that forms plugs in the eccrine sweat ducts. Topical anticholinergics may also be used. Instruction on proper methods and timing of antiperspirants enhances effect and may be effective alone or in combination with other treatments in patients with hyperhidrosis.

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