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Sarker - Pharmaceutical Emulsions A Drug Developers Toolbag

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Sarker Pharmaceutical Emulsions A Drug Developers Toolbag
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This edition first published 2013 2013 by John Wiley Sons Ltd Wiley - photo 1

This edition first published 2013 2013 by John Wiley & Sons, Ltd

Wiley Blackwell is an imprint of John Wiley & Sons, formed by the merger of Wiley's global Scientific, Technical and Medical business with Blackwell Publishing.

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All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.

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Limit of Liability/Disclaimer of Warranty: While the publisher and author(s) have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. It is sold on the understanding that the publisher is not engaged in rendering professional services and neither the publisher nor the author shall be liable for damages arising herefrom. If professional advice or other expert assistance is required, the services of a competent professional should be sought.

Library of Congress Cataloging-in-Publication Data

Sarker, Dipak K., author.

Pharmaceutical emulsions : a drug developer's toolbag / by Dipak K. Sarker.

p. ; cm.

Includes bibliographical references and index.

ISBN 978-0-470-97683-8 (cloth)

I. Title.

[DNLM: 1. Emulsions chemistry. 2. Biopharmaceutics standards. 3. Chemistry, Pharmaceutical methods. QV 786.5.C7]

RS420

615.19 dc23

2013018795

A catalogue record for this book is available from the British Library.

Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.

Dedicated to my two fabulous sons
Hugh Callum Sarker
and
Noah Marcus Vesco Sarker

Mathematical symbols (with normal units)
Greek
stress (Pa)
shear stress (Pa), decay time (s1), delay time (s1)
dotshear rate (Hz, s1)
surface excess concentration (mol/m2)
Debye length (m)
micron (106 m), ionic strength (mol/dm3, M)
bulk viscosity, coefficient of viscosity (mPa s, cP, cSt)
*complex bulk viscosity (Pas)
dsurface (dilational) viscosity (mN s/m)
ssurface (shear) viscosity (N/s/m)
Picture 2dielectric constant (dimensionless), permittivity (8.854 1010 C2/N/m2)
Picture 3strain (L/L, where L is length)
zeta potential (mV)
density, bulk phase (g/cm3)
density difference (medium minus dispersed phase) (g/cm3)
surface tension (mN/m)
phase volume (dimensionless)
surface potential (mV)
contact angle ()
surface pressure (mN/m)
wavelength (nm)
Nfrequency, wavenumber (cm)
Latin
HHamaker constant for constants based on interaction of oil and water [(oiloil)0.5 (waterwater)0.5]2 (1 1020 J)
NaAvogadro's number (6.022 1023)
Rgas constant (8.314 J/K/mol)
Rgradius of gyration (m)
gacceleration due to gravity (9.81 m/s2)
GYoung's modulus (Pa)
G*complex modulus (Pa)
G'storage modulus (Pa)
G''loss modulus (Pa)
PLaplace pressure (Pa, N/m2)
Kdissociation constant of ionisation
Ppartition coefficient ([octanol]/[water])
kBBoltzmann constant (1.381 1023 J/K)
krate constant (s1)
Ttemperature (C, K)
ttime (s)
Eddilational modulus (mN/m)
Ecomplex elastic modulus (mN/m)
D4,3usual hydrodynamic particle diameter (by volume) (nm)
D3,2Sauter hydrodynamic particle diameter (by area) (nm)
Ddiffusion coefficient (cm2/s)
exp or eexponent, exponential
Other symbols are explained at their point of use.
Acronyms and abbreviations
A/Wairwater system
ADMEadsorption, distribution, metabolism and excretion (of a drug)
AFMatomic force microscopy
CMCcritical micelle concentration
DDSdrug delivery system
DLSdynamic light scattering
DLVOa theory from Derjaguin, Landau, Verwey and Overbeek
DSCdifferential scanning calorimetry
EMEAEuropean Medicines Agency (a.k.a. EMA)
EPRenhanced permeability and retention (effect)
FDAFood and Drug Administration (USA)
FDG2-fluoro-2-deoxy-d-glucose
GCPgood clinical practice
GI tractgastrointestinal tract
GLPgood laboratory practice
GMPgood manufacturing practice
HLBhydrophilelipophile balance
ICHInternational Conference on Harmonisation
ISOInternational Standards Organization (Geneva)
IVintravenous
LCST/HCSTlower or higher critical solution temperature
LNClipid nanocapsule
LNPlipid nanoparticle
MHRAMedicines Health and Regulatory (products) Agency (UK)
NPDnew (medicinal) product development
O/Woil-in-water system
PCLpoly(caprolactone)
PCSphoton correlation spectroscopy
PEGpoly(ethylene glycol)
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