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Jame Abraham - The Bethesda Handbook of Clinical Oncology

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The Bethesda Handbook of Clinical Oncology: summary, description and annotation

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The Bethesda Handbook of Clinical Oncology is a comprehensive review of the management of numerous cancer types, emphasizing practical information that can be applied in everyday, fast-moving patient care situations. With contributions from experts and scholars at the National Cancer Institute, National Institutes of Health, Cleveland Clinic, and other renowned institutions, this latest edition has been thoroughly revised with new content and continues to provide practical guidance on how to evaluate, diagnose, and treat cancer patients.Designed for quick and easy accessibility of clinically relevant information.Features a new comprehensive chapter on the principles and practice of immunotherapy.Disease-specific chapters now include information on relevant and appropriate immunotherapeutic drugs.Covers a range of solid-tumor, blood, and other cancers, as well as infection management, nutrition, and palliative care.Combines concise and clear information with tables, images, and algorithms; now with even more algorithms to help fine-tune clinical decision-making.Useful for oncologists, oncology nurses, oncology fellows, residents, and allied health professionals.Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities!Read directly on your preferred device(s ), such as computer, tablet, or smartphoneEasily convert to audiobook , powering your content with natural language text-to-speechAdapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

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EDITORS JAME ABRAHAM MD FACP Director Breast Oncology Program Taussig Cancer - photo 1

EDITORS JAME ABRAHAM MD FACP Director Breast Oncology Program Taussig Cancer - photo 2

EDITORS

JAME ABRAHAM, MD, FACP

Director, Breast Oncology Program Taussig Cancer Institute,

Professor of Medicine, Lerner College of Medicine,

Cleveland Clinic, Cleveland, Ohio

James L. Gulley, MD, PhD, FACP

Director, Medical Oncology Service

Center for Cancer Research;

National Cancer Institute

National Institutes of Health;

Bethesda, Maryland

Formerly of Emory University School of Medicine,

and Loma Linda University School of Medicine

Senior Acquisitions Editor Ryan Shaw Editorial Coordinator John Larkin - photo 3

Senior Acquisitions Editor: Ryan Shaw

Editorial Coordinator: John Larkin

Marketing Manager: Rachel Mante Leung

Production Project Manager: Kim Cox

Design Coordinator: Holly McLaughlin

Manufacturing Coordinator: Beth Welsh

Prepress Vendor: Newgen Knowledge Works Pvt. Ltd., Chennai, India

Fifth Edition

Copyright 2019 Wolters Kluwer.

2001 Market Street, Philadelphia, PA 19103 USA

Copyright 2000, 2005, 2010, 2014, Wolters Kluwer Health / Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at permissions@lww.com, or via our website at lww.com (products and services).

987654321

Printed in China

Library of Congress Cataloging-in-Publication Data

Names: Abraham, Jame, editor. | Gulley, James L. (James Leonard), 1964 editor.

Title: The Bethesda handbook of clinical oncology / editors, Jame Abraham, James L. Gulley.

Other titles: Handbook of clinical oncology

Description: Fifth edition. | Philadelphia, PA : Wolters Kluwer, [2019] |

Includes bibliographical references and index.

Identifiers: LCCN 2017056079 | ISBN 9781496344182 (Hardback : alk. paper)

Subjects: | MESH: Neoplasmstherapy | Handbooks

Classification: LCC RC262.5 | NLM QZ 39 | DDC 616.99/4dc23

LC record available at https://lccn.loc.gov/2017056079

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

We dedicate this book to those lives that are touched by cancer and to their caregivers who spend endless hours taking care of them.

May I never forget that the patient is a fellow creature in pain. May I never consider him merely a vessel of disease.

Maimonides (Twelfth-century philosopher and physician)

Jame Abraham, MD, FACP Director, Breast Oncology Program, Taussig Cancer Institute, Professor of Medicine, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio

David J. Adelstein, MD Professor, Department of Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio; Staff, Department of Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio

Piyush K. Agarwal, MD Head, Bladder Cancer Section, Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Tenure-Track Investigator, Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Sanjiv S. Agarwala, MD Professor, Temple University School of Medicine, Philadelphia, Pennsylvania; Chief of Medical Oncology and Hematology; Director, Melanoma and Immunology Program, St. Lukes Cancer Center, Easton, Pennsylvania

Christina M. Annunziata, MD, PhD Investigator, Womens Malignancies Branch, National Cancer Institute, Bethesda, Maryland

Andrea B. Apolo, MD Chief, Bladder Cancer Section, Investigator and Lasker Scholar, Center for Cancer Research, Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Ananth K. Arjunan, MD Fellow, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania

Philip M. Arlen, MD Attending Physician, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Ann Berger MSN MD Chief of Pain and Palliative Care, National Institutes of Health, Clinical Center, Bethesda, Maryland

Christina Brzezniak, DO Chief of Thoracic Oncology, John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland

Brian Burkey, MD Professor, OtolaryngologyHead and Neck Surgery, Vice-Chairman, Head and Neck Institute, Cleveland Clinic and Foundation, Cleveland, Ohio

George Carter, MMS PA-C National Institutes of Health, NCL, Medical Oncology Branch, Bethesda, Maryland

Julia Cheringal, MD Medical Oncology Fellow, John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland

Michael Craig, MD Professor, Department of Medicine, Section Chief, West Virginia University Cancer Institute, Morgantown, West Virginia

William L. Dahut, MD Senior Investigator, Genitourinary Malignancies Branch, National Institutes of Health, Bethesda, Maryland

Erin F. Damery, PharmD, BCOP

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