EDITORS
JAME ABRAHAM, MD, FACP
Director, Breast Oncology Program Taussig Cancer Institute,
Professor of Medicine, Lerner College of Medicine,
Cleveland Clinic, Cleveland, Ohio
James L. Gulley, MD, PhD, FACP
Director, Medical Oncology Service
Center for Cancer Research;
National Cancer Institute
National Institutes of Health;
Bethesda, Maryland
Formerly of Emory University School of Medicine,
and Loma Linda University School of Medicine
Senior Acquisitions Editor: Ryan Shaw
Editorial Coordinator: John Larkin
Marketing Manager: Rachel Mante Leung
Production Project Manager: Kim Cox
Design Coordinator: Holly McLaughlin
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: Newgen Knowledge Works Pvt. Ltd., Chennai, India
Fifth Edition
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987654321
Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Abraham, Jame, editor. | Gulley, James L. (James Leonard), 1964 editor.
Title: The Bethesda handbook of clinical oncology / editors, Jame Abraham, James L. Gulley.
Other titles: Handbook of clinical oncology
Description: Fifth edition. | Philadelphia, PA : Wolters Kluwer, [2019] |
Includes bibliographical references and index.
Identifiers: LCCN 2017056079 | ISBN 9781496344182 (Hardback : alk. paper)
Subjects: | MESH: Neoplasmstherapy | Handbooks
Classification: LCC RC262.5 | NLM QZ 39 | DDC 616.99/4dc23
LC record available at https://lccn.loc.gov/2017056079
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We dedicate this book to those lives that are touched by cancer and to their caregivers who spend endless hours taking care of them.
May I never forget that the patient is a fellow creature in pain. May I never consider him merely a vessel of disease.
Maimonides (Twelfth-century philosopher and physician)
Jame Abraham, MD, FACP Director, Breast Oncology Program, Taussig Cancer Institute, Professor of Medicine, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio
David J. Adelstein, MD Professor, Department of Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio; Staff, Department of Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio
Piyush K. Agarwal, MD Head, Bladder Cancer Section, Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Tenure-Track Investigator, Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Sanjiv S. Agarwala, MD Professor, Temple University School of Medicine, Philadelphia, Pennsylvania; Chief of Medical Oncology and Hematology; Director, Melanoma and Immunology Program, St. Lukes Cancer Center, Easton, Pennsylvania
Christina M. Annunziata, MD, PhD Investigator, Womens Malignancies Branch, National Cancer Institute, Bethesda, Maryland
Andrea B. Apolo, MD Chief, Bladder Cancer Section, Investigator and Lasker Scholar, Center for Cancer Research, Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Ananth K. Arjunan, MD Fellow, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania
Philip M. Arlen, MD Attending Physician, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Ann Berger MSN MD Chief of Pain and Palliative Care, National Institutes of Health, Clinical Center, Bethesda, Maryland
Christina Brzezniak, DO Chief of Thoracic Oncology, John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland
Brian Burkey, MD Professor, OtolaryngologyHead and Neck Surgery, Vice-Chairman, Head and Neck Institute, Cleveland Clinic and Foundation, Cleveland, Ohio
George Carter, MMS PA-C National Institutes of Health, NCL, Medical Oncology Branch, Bethesda, Maryland
Julia Cheringal, MD Medical Oncology Fellow, John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland
Michael Craig, MD Professor, Department of Medicine, Section Chief, West Virginia University Cancer Institute, Morgantown, West Virginia
William L. Dahut, MD Senior Investigator, Genitourinary Malignancies Branch, National Institutes of Health, Bethesda, Maryland
Erin F. Damery, PharmD, BCOP
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