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Arun D. Singh - Clinical Ophthalmic Oncology: Retinal Tumors

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Arun D. Singh Clinical Ophthalmic Oncology: Retinal Tumors

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Written by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncologys clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume provides diagnosis and therapy for retinal tumors, including vitreoretinal lymphoma and paraneoplastic disorders.

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Editors Arun D Singh and Bertil E Damato Clinical Ophthalmic Oncology - photo 1
Editors
Arun D. Singh and Bertil E. Damato
Clinical Ophthalmic Oncology Retinal Tumors 3rd ed. 2019
Editors Arun D Singh Cleveland Clinic Foundation Cole Eye Institute - photo 2
Editors
Arun D. Singh
Cleveland Clinic Foundation, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
Bertil E. Damato
University of Oxford, Oxford, UK
ISBN 978-3-030-04112-0 e-ISBN 978-3-030-04113-7
https://doi.org/10.1007/978-3-030-04113-7
Library of Congress Control Number: 2019933400
Springer Nature Switzerland AG 2019
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Ophthalmic tumors are rare and diverse so their diagnosis can be quite complex. Treatment usually requires special expertise and equipment and in many instances is controversial. The field is advancing rapidly, because of accelerating progress in tumor biology, pharmacology, and instrumentation. Increasingly, the care of patients with an ocular or adnexal tumor is provided by a multidisciplinary team, consisting of ocular oncologists, general oncologists, radiotherapists, pathologists, psychologists, and other specialists.

For all these reasons, we felt that there was a need for the new edition of the textbook providing a balanced view of current clinical practice. Although each section of Clinical Ophthalmic Oncology , Third Edition , now represents a standalone volume, each chapter has a similar layout with boxes that highlight the key features, tables that provide comparison, and flow diagrams that outline therapeutic approaches.

The enormous task of editing a multi-author, multivolume textbook could not have been possible without the support and guidance by the staff at Springer: Caitlin Prim, Melanie Zerah, ArulRonika Pathinathan, and Karthik Rajasekar. Michael D. Sova kept the pressure on to meet the production deadlines.

It is our sincere hope that our efforts will meet the high expectation of the readers.

Arun D. Singh
Bertil E. Damato
Cleveland, OH, USA Oxford, UK
Acknowledgements

To my parents who educated me beyond their means, my wife Annapurna, and my children, Nakul and Rahul, who make all my efforts worthwhile Arun D. Singh.

To my family, Frankanne, Erika, Stephen, and Anna Bertil E. Damato.

Contents
Ehud Reich , Caroline Thaung and Mandeep S. Sagoo
Thomas M. Aaberg Jr. and Liliya Shevchenko
Sachin M. Salvi , Paul A. Rundle , Ian Rennie and Arun D. Singh
Christopher Seungkyu Lee , Sungchul Lee and Arun D. Singh
Elias I. Traboulsi , Matteo Scaramuzzi and Arun D. Singh
Javier Elizalde , Mara de la Paz , Rafael I. Barraquer and Arun D. Singh
Mary E. Aronow , Manmeet S. Ahluwalia , David M. Peereboom and Arun D. Singh
Peter H. Tang , Lejla Vajzovic and Prithvi Mruthyunjaya
Elaine Binkley , Elias I. Traboulsi and Arun D. Singh
Ilya Leskov and Arun D. Singh
Editors and Contributors
Editors
Arun D. Singh MD
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA
Bertil E. Damato MD, PhD, FRCOphth
University of Oxford, Oxford, UK
Contributors
Thomas M. Aaberg Jr MD
Department of Ophthalmology, Retina Specialists of Michigan, Michigan State University, Spectrum Health, Grand Rapids, MI, USA
Manmeet S. Ahluwalia MD
The Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA
Mary E. Aronow MD
Massachusetts Eye and Ear, Ocular Melanoma Center and Retina Service, Harvard Medical School, Boston, MA, USA
Rafael I. Barraquer MD, PhD
Centro de Oftalmologa Barraquer, Barcelona, Spain
Elaine Binkley MD
Department of Ophthalmology, Cole Eye Institute (i32), Cleveland Clinic Foundation, Cleveland, OH, USA
Maria de la Paz MD, PhD
Centro de Oftalmologa Barraquer, Barcelona, Spain
Javier Elizalde MD, PhD
Centro de Oftalmologa Barraquer, Barcelona, Spain
Christopher Seungkyu Lee MD, PhD
Department of Ophthalmology, Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea
Sungchul Lee MD, PhD
Department of Ophthalmology, Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea
Ilya Leskov MD
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
Prithvi Mruthyunjaya MD, MHS
Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA
David M. Peereboom MD, FACP
The Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA
Ehud Reich MD
Department of Ophthalmology and Davidoff Center for Oncology, Rabin Medical Center/Sackler Medical School, Tel Aviv University, Petach Tikva, Israel
Ian Rennie FRCOphth
Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, UK
Paul A. Rundle FRCOphth
Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, UK
Mandeep S. Sagoo MB, PhD, FRCOphth, FRCS (Ed)
Department of Ocular Oncology, NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK
Sachin M. Salvi FRCOphth
Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, UK
Matteo Scaramuzzi MD
Department of Pediatric Ophthalmology and Strabismus, Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
Liliya Shevchenko DO
Department of Ophthalmology/Vitreoretinal Disease, Retina Specialists of Michigan, Grand Rapids, MI, USA
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